China Biggest Factory & Manufacturer supply Inositol Nicotinate 500MT/Year CAS NO.6556-11-2

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

Product information

Inositol nicotinate Basic information Product Name: Inositol nicotinate Synonyms: MYO-INOSITOL HEXANICOTINATE;MYO-INOSITOL HEXA-3-PYRIDINECARBOXYLATE;INOSITOL HEXANICOTINATE;inositol hexa-3-pyridinecarboxylate;INOSITOL NIACINATE;INOSITOL NICOTINATE;dilcit;dilexpal CAS: 6556-11-2 MF: C42H30N6O12 MW: 810.72 EINECS: 229-485-9 Product Categories: Circulatory system agents;Nutritional fortification substances;Organics;Nutritional Supplements Mol File: 6556-11-2.mol   Inositol nicotinate Chemical Properties Melting point  254-256 °C(lit.) Boiling point  755.54°C (rough estimate) density  1.3348 (rough estimate) refractive index  1.6400 (estimate) storage temp.  Inert atmosphere,Room Temperature solubility  Aqueous Acid (Slightly, Heated), DMSO (Slightly, Heated, Sonicated) pka 3.92±0.10(Predicted) form  Solid color  White to Off-White Merck  13,5002 CAS DataBase Reference 6556-11-2(CAS DataBase Reference) EPA Substance Registry System Inositol nicotinate (6556-11-2)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  2 RTECS  NM7535400 MSDS Information Provider Language Inositol nicotinate English SigmaAldrich English   Inositol nicotinate Usage And Synthesis Originator Hexanicotol,Philadelphia,US,1962 Uses myo-Inositol Hexanicotinate is an nicotinate conjugate of myo-inositol, an structural basis for a number of secondary messengers. Uses benzidine substitute Manufacturing Process 100 g of nicotinic acid were suspended in 265 ml of distilled and dried pyridine without stirring. 68 g of phosphorus oxychloride were added dropwise to this mixture under continual stirring. The temperature of the reactants, initially at 20°C, was allowed to rise to about 60°C, and this temperature was maintained for a further 60 minutes. Thereafter 24.5 g of meso-inositol wereadded gradually, the temperature being controlled so that it did not exceed about 80°C. The reactants were maintained at this temperature for from 2 to 3 hours, and thereafter the reaction mixture was poured into 500 ml of water. The pyridine salts formed during the reaction readily dissolved, and the mesoinositol hexanicotinate which had formed crystallized out. The ester was filtered off and washed with water and acetone or alcohol. Finally, the mesoinositol hexanicotinate was dried at 100°C. The yield was 90%, the melting point of the product was 258°C to 260°C. and the chlorine content <0.01%. Brand name Hexopal (Sterling Winthrop); Linodil (Sterling Winthrop); Palohex (Sterling Winthrop). Therapeutic Function Vasodilator Clinical Use Peripheral vascular disease Hyperlipidaemia Drug interactions Potentially hazardous interactions with other drugs Statins: increased risk of myopathy. Metabolism Inositol nicotinate is believed to be slowly hydrolysed to nicotinic acid. The main route of metabolism is then conversion to N-methylnicotinamide and the 2-pyridone and 4-pyridone derivatives; nicotinuric acid is also formed. Small amounts of nicotinic acid are excreted unchanged in urine.   Inositol nicotinate Preparation Products And Raw materials Raw materials Phosphorus oxychloride-->Inositol-->Nicotinic acid-->Phosphorus oxychloride