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Home > Products >  China Largest Manufacturer factory sales D-PHENYLALANINE CAS 673-06-3 for 500MT/Year

China Largest Manufacturer factory sales D-PHENYLALANINE CAS 673-06-3 for 500MT/Year CAS NO.673-06-3

  • FOB Price: USD: 1.00-2.00 /Kilogram Get Latest Price
  • Min.Order: 500 Kilogram
  • Payment Terms: L/C,D/A,D/P,T/T,MoneyGram,Other
  • Available Specifications:

    AAAAA(50-100)KilogramAAAAA(100-500)Kilogram

  • Product Details

Keywords

  • D-PHENYLALANINE
  • D-PHENYLALANINE
  • 673-06-3

Quick Details

  • ProName: China Largest Manufacturer factory sal...
  • CasNo: 673-06-3
  • Molecular Formula: 673-06-3
  • Appearance: white powder
  • Application: Pharm chemicals industry
  • DeliveryTime: 3-5 days
  • PackAge: 25KG/Drum
  • Port: Shanghai Guangzhou Qingdao Shenzhen
  • ProductionCapacity: 20 Metric Ton/Month
  • Purity: 99%
  • Storage: 2-8°C
  • Transportation: By air /Sea/ coruier
  • LimitNum: 500 Kilogram
  • Heavy metal: 10PPM
  • Color: red
  • Melting point: ≥350°C
  • Boiling point: 363.24°C (rough estimate)
  • density: 1.667
  • solubility: 1 M NaOH: 10 mg/mL, dark green
  • Water Solubility: <0.1 g/100 mL at 21 oC
  • Stability: Stable. Combustible. Incompatible with...

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                                PRODUCT DETAILS                           

D-Phenylalanine Basic information
Description In vitro In vivo Biological Activity Benefits Side Effects
Product Name: D-Phenylalanine
Synonyms: D-beta-Phenyl-alpha-aminopropionic acid;d-alpha-aminohydrocinnamic acid;D-ALPHA-AMINO-BETA-PHENYL-PROPIONIC ACID;D-2-AMINO-3-PHENYLPROPANOIC ACID;D(+)-PHENYLALANINE;D-PHENYLALANINE;d-phe;H-D-PHE-OH
CAS: 673-06-3
MF: C9H11NO2
MW: 165.19
EINECS: 211-603-5
Product Categories: Nateglinide intermediate;Inhibitors;amino acid;chemicals;organic acids;pharmaceutical intermediate;Amino ACIDS SERIES;Aromatic Propionic Acids;Phenylalanine [Phe, F];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;phenlalnine;Benzene derivatives;Amino Acids
Mol File: 673-06-3.mol
D-Phenylalanine Structure
 
D-Phenylalanine Chemical Properties
Melting point  273-276 °C(lit.)
alpha  33.5 º (c=2, H2O)
Boiling point  293.03°C (rough estimate)
density  1.1603 (rough estimate)
refractive index  34 ° (C=2, H2O)
storage temp.  Store at RT.
solubility  Methanol (Slightly), Water (Slightly)
pka 2.2(at 25℃)
form  Powder
color  White to off-white
Water Solubility  27 g/L (20 ºC)
Merck  14,7271
BRN  2804068
Stability: Stable. Incompatible with strong oxidizing agents, acids, bases.
InChIKey COLNVLDHVKWLRT-MRVPVSSYSA-N
CAS DataBase Reference 673-06-3(CAS DataBase Reference)
EPA Substance Registry System D-Phenylalanine (673-06-3)
 
Safety Information
Hazard Codes  Xi,C
Risk Statements  34
Safety Statements  24/25-45-36/37/39-27-26
WGK Germany  3
RTECS  AY7533000
Hazard Note  Irritant
TSCA  Yes
HS Code  29224995
Toxicity TDLo orl-hmn: 500 mg/kg/5W-I:GIT JACTDZ 1(3),124,82
MSDS Information
Provider Language
D-alpha-Amino-beta-phenylpropionic acid English
SigmaAldrich English
ACROS English
ALFA English
 
D-Phenylalanine Usage And Synthesis
Description D-phenylalanine is an inhibitor of enzymes that inactivate enkephalins. Enkephalins are naturally occurring morphine-like peptides that function to reduce pain. By blocking enzymes from degrading enkephalins, D-phenylalanine can reduce pain severity. Phenylalanine is the only amino acid other than methionine in which both isomers, L and D, are readily absorbed. DLPA is 50% D-phenylalanine and 50% L-phenylalanine, making it clinically useful as a neurotransmitter precursor and as a potential pain mediator.
Phenylalanine is found in three different forms. The natural form, found in food, is also called L-phenylalanine. There’s also a synthetic form, D-phenylalanine, which is very similar to the natural version. Both of these forms come with their own unique benefits, but if you want to get the most out of them, you’ll want to look at the third form: DL-phenylalanine. This form combines both the “L” and “D” forms, creating a supplement with the benefits of both types.
In vitro The binding of D-Phenylalanine to carboxypeptidase A confers anion sensitivity upon the function of the enzyme by breaking the hydrogen bond between the active site base, Glu-270, and the zinc-bound water molecule.
In vivo D-Phenylalanine (500 mg/kg p.o.) produces a small increase in aversive threshold which is not statistically significant and not naloxone reversible. Acetylsalicylic acid (200 mg/kg p.o.) but not zomepirac sodium (200 mg/kg p.o.) in combination with D-phenylalanine (500 mg/kg) produces a small statistically significant increase in aversive threshold.
Biological Activity DL-Phenylalanine (DLPA) is marketed as a nutritional supplement for its purported analgesic and antidepressant activities. DL-Phenylalanine is a mixture of D-phenylalanine and L-phenylalanine. The reputed analgesic activity of DL-phenylalanine may be explained by the possible blockage by D-phenylalanine of enkephalin degradation by the enzyme carboxypeptidase A. The mechanism of DL-phenylalanine's supposed antidepressant activity may be accounted for by the precursor role of L-phenylalanine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain levels of norepinephrine and dopamine are thought to have an antidepressant effect. D-Phenylalanine is absorbed from the small intestine and transported to the liver via the portal circulation. A small amount of D-phenylalanine appears to be converted to L-phenylalanine. D-Phenylalanine is distributed to the various tissues of the body via the systemic circulation. It appears to cross the blood–brain barrier less efficiently than L-phenylalanine, and so a small amount of an ingested dose of D-phenylalanine is excreted in the urine without penetrating the central nervous system.

 

Benefits D-phenylalanine (DPA) decreases pain by blocking the enzymes that break down the body's natural painkillers. Clinical studies suggest DPA may inhibit some types of chronic pain.
Certain amino acids have been found to raise pain thresholds and increase tolerance to pain. One of these, a synthetic amino acid called D-phenylalanine (DPA), decreases pain by blocking the enzymes that break down endorphins and enkephalins, the body's natural pain-killing chemicals. DPA may also produce pain relief by other mechanisms, which are not well understood.
In animal studies, DPA decreased chronic pain within 15 minutes of administration and the effects lasted up to six days. It also decreased responses to acute pain. These findings have been independently verified in at least five other studies. Clinical studies on humans suggest DPA may inhibit some types of chronic pain, but it has little effect on most types of acute pain.
Side Effects Phenylalanine is found in many protein-containing foods and is “generally recognized as safe” by the Food and Drug Administration (FDA). The amount of this amino acid found in foods should not pose a risk for otherwise healthy individuals. What’s more, few or no side effects are generally observed at supplement doses of 23–45 mg per pound (50–100 mg per kg) of body weight. However, it may be best for pregnant women to avoid taking phenylalanine supplements.
Description D-Phenylalanine, also known as D-alpha-Amino-beta-phenylpropionic acid, is a kind of non-proteinogenic amino acid. The biological function of D-phenylalanine remains unclear. However, it has certain anti-depressant, analgesic activities and pharmacological activity at niacin receptor II. The mechanism action of its analgesic activity seems to originate from its inhibition of enkephalin degradation by the carboxypeptidase A. Enkephalins are part of your body’s natural pain relief system. When they are broken down by enkephalinase, this contributes to the sensation of pain. D-Phenylalanine is specifically thought to be beneficial for reducing feelings of chronic pain. D-phenylalanine has been used with mixed results to treat chronic pain, including pain caused by rheumatoid arthritis. The primary use of D-phenylalanine as a health supplement is the relief of discomfort.
Chemical Properties White crystalline powder
Uses D-Phenylalanine, the stereoisomer of L-Phenylalanine (P319415) has been used in the synthesis of Schaeffer’s acid analogues as important structures in tuberculostatic design. They exhibit the ability to inhibit Mycobacterium tuberculosis type II dehydroquinase.
Definition ChEBI: D-phenylalanine is the D-enantiomer of phenylalanine. It is a phenylalanine and a D-alpha-amino acid. It is a conjugate base of a D-phenylalaninium. It is a conjugate acid of a D-phenylalaninate. It is an enantiomer of a L-phenylalanine. It is a tautomer of a D-phenylalanine zwitterion.
General Description D-phenylalanine appears as needles or prisms.
Air & Water Reactions Water soluble. Aqueous solutions are weakly acidic.
Reactivity Profile D-alpha-Amino-beta-phenylpropionic acid may be light sensitive. D-alpha-Amino-beta-phenylpropionic acid reacts with strong oxidizing agents, acids and bases. . Act as weak acids in solution.
Fire Hazard Flash point data for D-alpha-Amino-beta-phenylpropionic acid are not available, however D-alpha-Amino-beta-phenylpropionic acid is probably combustible.
Pharmacokinetics D-Phenylalanine is the synthetic dextro isomer of phenylalanine, an essential amino acid with anti-depressant and analgesic activities. D-Phenylalanine is converted into tyrosine and tyrosine in turn is converted into L-dopa, norepinephrine, and epinephrine, three key neurotransmitters. As a result this agent is associated with elevated levels of the neurotransmitters dopamine and norepinephrine in the brain, which may alleviate symptoms of depression. In addition, as an inhibitor of enkephalinase, which metabolizes endorphins, D-phenylalanine may be used to treat chronic pain through blocking the break down of endorphins (natural pain killers).
Safety Profile Mildly toxic by intraperitoneal route. Human systemic effects by ingestion: nausea, hypermotility, diarrhea. When heated to decomposition it emits toxic fumes of NOx.
References #
#
Christianson, D. W., et al. "Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A. " Journal of Biological Chemistry264.22(1989):12849-53.
 
D-Phenylalanine Preparation Products And Raw materials
Raw materials Acetic anhydride-->DL-Phenylalanine
Preparation Products BOC-D-Phenylalanine-->D-Phenylalanine methyl ester hydrochloride-->1-[(4R)-4-(phenylmethyl)-2-thioxo-3-thiazolidinyl]-Ethanone-->H-D-PHE-OTBU HCL
 
 


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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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                                                       Product information

D-Phenylalanine Basic information
Description In vitro In vivo Biological Activity Benefits Side Effects
Product Name: D-Phenylalanine
Synonyms: D-beta-Phenyl-alpha-aminopropionic acid;d-alpha-aminohydrocinnamic acid;D-ALPHA-AMINO-BETA-PHENYL-PROPIONIC ACID;D-2-AMINO-3-PHENYLPROPANOIC ACID;D(+)-PHENYLALANINE;D-PHENYLALANINE;d-phe;H-D-PHE-OH
CAS: 673-06-3
MF: C9H11NO2
MW: 165.19
EINECS: 211-603-5
Product Categories: Nateglinide intermediate;Inhibitors;amino acid;chemicals;organic acids;pharmaceutical intermediate;Amino ACIDS SERIES;Aromatic Propionic Acids;Phenylalanine [Phe, F];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;phenlalnine;Benzene derivatives;Amino Acids
Mol File: 673-06-3.mol
D-Phenylalanine Structure
 
D-Phenylalanine Chemical Properties
Melting point  273-276 °C(lit.)
alpha  33.5 º (c=2, H2O)
Boiling point  293.03°C (rough estimate)
density  1.1603 (rough estimate)
refractive index  34 ° (C=2, H2O)
storage temp.  Store at RT.
solubility  Methanol (Slightly), Water (Slightly)
pka 2.2(at 25℃)
form  Powder
color  White to off-white
Water Solubility  27 g/L (20 ºC)
Merck  14,7271
BRN  2804068
Stability: Stable. Incompatible with strong oxidizing agents, acids, bases.
InChIKey COLNVLDHVKWLRT-MRVPVSSYSA-N
CAS DataBase Reference 673-06-3(CAS DataBase Reference)
EPA Substance Registry System D-Phenylalanine (673-06-3)
 
Safety Information
Hazard Codes  Xi,C
Risk Statements  34
Safety Statements  24/25-45-36/37/39-27-26
WGK Germany  3
RTECS  AY7533000
Hazard Note  Irritant
TSCA  Yes
HS Code  29224995
Toxicity TDLo orl-hmn: 500 mg/kg/5W-I:GIT JACTDZ 1(3),124,82
MSDS Information
Provider Language
D-alpha-Amino-beta-phenylpropionic acid English
SigmaAldrich English
ACROS English
ALFA English
 
D-Phenylalanine Usage And Synthesis
Description D-phenylalanine is an inhibitor of enzymes that inactivate enkephalins. Enkephalins are naturally occurring morphine-like peptides that function to reduce pain. By blocking enzymes from degrading enkephalins, D-phenylalanine can reduce pain severity. Phenylalanine is the only amino acid other than methionine in which both isomers, L and D, are readily absorbed. DLPA is 50% D-phenylalanine and 50% L-phenylalanine, making it clinically useful as a neurotransmitter precursor and as a potential pain mediator.
Phenylalanine is found in three different forms. The natural form, found in food, is also called L-phenylalanine. There’s also a synthetic form, D-phenylalanine, which is very similar to the natural version. Both of these forms come with their own unique benefits, but if you want to get the most out of them, you’ll want to look at the third form: DL-phenylalanine. This form combines both the “L” and “D” forms, creating a supplement with the benefits of both types.
In vitro The binding of D-Phenylalanine to carboxypeptidase A confers anion sensitivity upon the function of the enzyme by breaking the hydrogen bond between the active site base, Glu-270, and the zinc-bound water molecule.
In vivo D-Phenylalanine (500 mg/kg p.o.) produces a small increase in aversive threshold which is not statistically significant and not naloxone reversible. Acetylsalicylic acid (200 mg/kg p.o.) but not zomepirac sodium (200 mg/kg p.o.) in combination with D-phenylalanine (500 mg/kg) produces a small statistically significant increase in aversive threshold.
Biological Activity DL-Phenylalanine (DLPA) is marketed as a nutritional supplement for its purported analgesic and antidepressant activities. DL-Phenylalanine is a mixture of D-phenylalanine and L-phenylalanine. The reputed analgesic activity of DL-phenylalanine may be explained by the possible blockage by D-phenylalanine of enkephalin degradation by the enzyme carboxypeptidase A. The mechanism of DL-phenylalanine's supposed antidepressant activity may be accounted for by the precursor role of L-phenylalanine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain levels of norepinephrine and dopamine are thought to have an antidepressant effect. D-Phenylalanine is absorbed from the small intestine and transported to the liver via the portal circulation. A small amount of D-phenylalanine appears to be converted to L-phenylalanine. D-Phenylalanine is distributed to the various tissues of the body via the systemic circulation. It appears to cross the blood–brain barrier less efficiently than L-phenylalanine, and so a small amount of an ingested dose of D-phenylalanine is excreted in the urine without penetrating the central nervous system.

 

Benefits D-phenylalanine (DPA) decreases pain by blocking the enzymes that break down the body's natural painkillers. Clinical studies suggest DPA may inhibit some types of chronic pain.
Certain amino acids have been found to raise pain thresholds and increase tolerance to pain. One of these, a synthetic amino acid called D-phenylalanine (DPA), decreases pain by blocking the enzymes that break down endorphins and enkephalins, the body's natural pain-killing chemicals. DPA may also produce pain relief by other mechanisms, which are not well understood.
In animal studies, DPA decreased chronic pain within 15 minutes of administration and the effects lasted up to six days. It also decreased responses to acute pain. These findings have been independently verified in at least five other studies. Clinical studies on humans suggest DPA may inhibit some types of chronic pain, but it has little effect on most types of acute pain.
Side Effects Phenylalanine is found in many protein-containing foods and is “generally recognized as safe” by the Food and Drug Administration (FDA). The amount of this amino acid found in foods should not pose a risk for otherwise healthy individuals. What’s more, few or no side effects are generally observed at supplement doses of 23–45 mg per pound (50–100 mg per kg) of body weight. However, it may be best for pregnant women to avoid taking phenylalanine supplements.
Description D-Phenylalanine, also known as D-alpha-Amino-beta-phenylpropionic acid, is a kind of non-proteinogenic amino acid. The biological function of D-phenylalanine remains unclear. However, it has certain anti-depressant, analgesic activities and pharmacological activity at niacin receptor II. The mechanism action of its analgesic activity seems to originate from its inhibition of enkephalin degradation by the carboxypeptidase A. Enkephalins are part of your body’s natural pain relief system. When they are broken down by enkephalinase, this contributes to the sensation of pain. D-Phenylalanine is specifically thought to be beneficial for reducing feelings of chronic pain. D-phenylalanine has been used with mixed results to treat chronic pain, including pain caused by rheumatoid arthritis. The primary use of D-phenylalanine as a health supplement is the relief of discomfort.
Chemical Properties White crystalline powder
Uses D-Phenylalanine, the stereoisomer of L-Phenylalanine (P319415) has been used in the synthesis of Schaeffer’s acid analogues as important structures in tuberculostatic design. They exhibit the ability to inhibit Mycobacterium tuberculosis type II dehydroquinase.
Definition ChEBI: D-phenylalanine is the D-enantiomer of phenylalanine. It is a phenylalanine and a D-alpha-amino acid. It is a conjugate base of a D-phenylalaninium. It is a conjugate acid of a D-phenylalaninate. It is an enantiomer of a L-phenylalanine. It is a tautomer of a D-phenylalanine zwitterion.
General Description D-phenylalanine appears as needles or prisms.
Air & Water Reactions Water soluble. Aqueous solutions are weakly acidic.
Reactivity Profile D-alpha-Amino-beta-phenylpropionic acid may be light sensitive. D-alpha-Amino-beta-phenylpropionic acid reacts with strong oxidizing agents, acids and bases. . Act as weak acids in solution.
Fire Hazard Flash point data for D-alpha-Amino-beta-phenylpropionic acid are not available, however D-alpha-Amino-beta-phenylpropionic acid is probably combustible.
Pharmacokinetics D-Phenylalanine is the synthetic dextro isomer of phenylalanine, an essential amino acid with anti-depressant and analgesic activities. D-Phenylalanine is converted into tyrosine and tyrosine in turn is converted into L-dopa, norepinephrine, and epinephrine, three key neurotransmitters. As a result this agent is associated with elevated levels of the neurotransmitters dopamine and norepinephrine in the brain, which may alleviate symptoms of depression. In addition, as an inhibitor of enkephalinase, which metabolizes endorphins, D-phenylalanine may be used to treat chronic pain through blocking the break down of endorphins (natural pain killers).
Safety Profile Mildly toxic by intraperitoneal route. Human systemic effects by ingestion: nausea, hypermotility, diarrhea. When heated to decomposition it emits toxic fumes of NOx.
References #
#
Christianson, D. W., et al. "Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A. " Journal of Biological Chemistry264.22(1989):12849-53.
 
D-Phenylalanine Preparation Products And Raw materials
Raw materials Acetic anhydride-->DL-Phenylalanine
Preparation Products BOC-D-Phenylalanine-->D-Phenylalanine methyl ester hydrochloride-->1-[(4R)-4-(phenylmethyl)-2-thioxo-3-thiazolidinyl]-Ethanone-->H-D-PHE-OTBU HCL

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