China Largest Manufacturer factory Supply Ambroxane CAS 6790-58-5 CAS NO.6790-58-5

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Ambroxane Basic information Product Name: Ambroxane Synonyms: Ambrox;Naphtho[2,1-b]furan,dodecahydro-3a,6,6,9a-tetramethyl-,[3aR-(3a.alpha.,5a.beta.,9a.al;naphtho[2,1-b]furan,dodecahydro-3a,6,6,9a-tetramethyl-,[3atheta-(3aalpha,5a;n-Epoxide;[3aR-(3aalpha,5abeta,9aalpha,9bbeta)]-dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan;Amberoxan;Ambropur;(-)-AMBROXIDE 99+% CAS: 6790-58-5 MF: C16H28O MW: 236.39 EINECS: 229-861-2 Product Categories: Flavors and Fragrances;Flavors & Fragrances;VX:15689727968 Mol File: 6790-58-5.mol   Ambroxane Chemical Properties Melting point  74-76 °C (lit.) alpha  -30 º (c=1% in toluene) Boiling point  273.9±8.0 °C(Predicted) density  0.939 FEMA  3471 | 1,5,5,9-TETRAMETHYL-13-OXATRICYCLO(8.3.0.0(4,9))TRIDECANE storage temp.  Sealed in dry,Room Temperature optical activity [α]20/D 29°, c = 1 in toluene JECFA Number 1240 InChIKey YPZUZOLGGMJZJO-LQKXBSAESA-N CAS DataBase Reference 6790-58-5(CAS DataBase Reference) NIST Chemistry Reference 8 «alpha»,12-epoxy-13,14,15,16-tertanorlabdane(6790-58-5) EPA Substance Registry System Naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)- (6790-58-5)   Safety Information WGK Germany  1 MSDS Information Provider Language SigmaAldrich English   Ambroxane Usage And Synthesis Uses ( )-Ambroxide can be used: To prepare (+)-sclareolide through C H oxidation strategy. As a substrate in C(sp3)-H alkylation/arylation studies of ethers. As a substrate in the study of ethereal hydrocarbon hydroperoxidation using singlet O2. Definition ChEBI: A diterpenoid derived from sclareol that is responsible for the odour of ambergris (a solid, waxy, flammable substance produced in the digestive system of sperm whales). Application Ambroxan has a strong, characteristic ambergris aroma. Used in high-grade perfumes and cosmetic essences, because it is non-irritating to the human body and non-allergic to animals, it is very suitable for fragrances for skin, hair and fabrics. Often used in soaps, talcum powders, creams and shampoos for perfuming and fixing fragrance. General Description Ambroxide is a terpenoid, which has vast applications in the perfume industry due to its fixative property and odor. Ambergris, which was originally sourced from sperm whale, has been substituted by synthetic ambroxides. Chemical Synthesis Perillyl alcohol is used as raw material to synthesize nordrone ether, which is oxidized by KMnO4 in two steps (Switzerland uses ozone oxidation, Russia uses sodium chromate oxidation). That is (1) alkaline oxidation; (2) weak acid oxidation. The oxide is obtained, and then the oxide is soaped, dehydrated and lactonized to obtain ambroxolide.  lactones are reduced to ambroxol with lithium aluminum hydride in ether (or with borane in tetrahydrofuran). D-camphor-β-sulfonic acid is used as a cyclizing agent to cyclize diols to obtain ambrox (foreign cyclizing agents include sulfuric acid, p-toluenesulfonic acid and β-naphthalenesulfonic acid, etc.).    Ambroxane Preparation Products And Raw materials Raw materials Tetrahydrofuran-->PARA TOLUENE-->Ozone-->Naphthalene-2-sulfonic acid-->Diborane-->D-CAMPHOR-->DIHYDRO CUMINYL ALCOHOL

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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                                                       Product information

Ambroxane Basic information Product Name: Ambroxane Synonyms: Ambrox;Naphtho[2,1-b]furan,dodecahydro-3a,6,6,9a-tetramethyl-,[3aR-(3a.alpha.,5a.beta.,9a.al;naphtho[2,1-b]furan,dodecahydro-3a,6,6,9a-tetramethyl-,[3atheta-(3aalpha,5a;n-Epoxide;[3aR-(3aalpha,5abeta,9aalpha,9bbeta)]-dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan;Amberoxan;Ambropur;(-)-AMBROXIDE 99+% CAS: 6790-58-5 MF: C16H28O MW: 236.39 EINECS: 229-861-2 Product Categories: Flavors and Fragrances;Flavors & Fragrances;VX:15689727968 Mol File: 6790-58-5.mol   Ambroxane Chemical Properties Melting point  74-76 °C (lit.) alpha  -30 º (c=1% in toluene) Boiling point  273.9±8.0 °C(Predicted) density  0.939 FEMA  3471 | 1,5,5,9-TETRAMETHYL-13-OXATRICYCLO(8.3.0.0(4,9))TRIDECANE storage temp.  Sealed in dry,Room Temperature optical activity [α]20/D 29°, c = 1 in toluene JECFA Number 1240 InChIKey YPZUZOLGGMJZJO-LQKXBSAESA-N CAS DataBase Reference 6790-58-5(CAS DataBase Reference) NIST Chemistry Reference 8 «alpha»,12-epoxy-13,14,15,16-tertanorlabdane(6790-58-5) EPA Substance Registry System Naphtho[2,1-b]furan, dodecahydro-3a,6,6,9a-tetramethyl-, (3aR,5aS,9aS,9bR)- (6790-58-5)   Safety Information WGK Germany  1 MSDS Information Provider Language SigmaAldrich English   Ambroxane Usage And Synthesis Uses ( )-Ambroxide can be used: To prepare (+)-sclareolide through C H oxidation strategy. As a substrate in C(sp3)-H alkylation/arylation studies of ethers. As a substrate in the study of ethereal hydrocarbon hydroperoxidation using singlet O2. Definition ChEBI: A diterpenoid derived from sclareol that is responsible for the odour of ambergris (a solid, waxy, flammable substance produced in the digestive system of sperm whales). Application Ambroxan has a strong, characteristic ambergris aroma. Used in high-grade perfumes and cosmetic essences, because it is non-irritating to the human body and non-allergic to animals, it is very suitable for fragrances for skin, hair and fabrics. Often used in soaps, talcum powders, creams and shampoos for perfuming and fixing fragrance. General Description Ambroxide is a terpenoid, which has vast applications in the perfume industry due to its fixative property and odor. Ambergris, which was originally sourced from sperm whale, has been substituted by synthetic ambroxides. Chemical Synthesis Perillyl alcohol is used as raw material to synthesize nordrone ether, which is oxidized by KMnO4 in two steps (Switzerland uses ozone oxidation, Russia uses sodium chromate oxidation). That is (1) alkaline oxidation; (2) weak acid oxidation. The oxide is obtained, and then the oxide is soaped, dehydrated and lactonized to obtain ambroxolide.  lactones are reduced to ambroxol with lithium aluminum hydride in ether (or with borane in tetrahydrofuran). D-camphor-β-sulfonic acid is used as a cyclizing agent to cyclize diols to obtain ambrox (foreign cyclizing agents include sulfuric acid, p-toluenesulfonic acid and β-naphthalenesulfonic acid, etc.).    Ambroxane Preparation Products And Raw materials Raw materials Tetrahydrofuran-->PARA TOLUENE-->Ozone-->Naphthalene-2-sulfonic acid-->Diborane-->D-CAMPHOR-->DIHYDRO CUMINYL ALCOHOL