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Home > Products >  China Largest Factory Manufacturer sales Sodium Chloride CAS 7647-14-5

China Largest Factory Manufacturer sales Sodium Chloride CAS 7647-14-5 CAS NO.7647-14-5

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  • Min.Order: 500 Kilogram
  • Payment Terms: L/C,D/A,D/P,T/T,MoneyGram,Other
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Keywords

  • Sodium Chloride
  • Sodium Chloride
  • 7647-14-5

Quick Details

  • ProName: China Largest Factory Manufacturer sal...
  • CasNo: 7647-14-5
  • Molecular Formula: 7647-14-5
  • Appearance: white powder
  • Application: Pharm chemicals industry
  • DeliveryTime: 3-5 days
  • PackAge: 25KG/Drum
  • Port: Shanghai Guangzhou Qingdao Shenzhen
  • ProductionCapacity: 20 Metric Ton/Month
  • Purity: 99%
  • Storage: 2-8°C
  • Transportation: By air /Sea/ coruier
  • LimitNum: 500 Kilogram
  • Heavy metal: 10PPM
  • Color: white
  • Melting point: ≥350°C
  • Boiling point: 363.24°C (rough estimate)
  • density: 1.667
  • solubility: 1 M NaOH: 10 mg/mL, dark green
  • Water Solubility: <0.1 g/100 mL at 21 oC
  • Stability: Stable. Combustible. Incompatible with...

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Sodium chloride Basic information
Product Name: Sodium chloride
Synonyms: Sodium chloride puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., >=99.5%;Sodium chloride puriss., meets analytical specification of Ph. Eur., BP, USP, 99.0-100.5% (calc. to the dried substance), <=0.00002% Al;Sodium chloride random crystals, optical grade, 99.98% trace metals basis;Sodium chloride ReagentPlus(R), >=99%;Sodium chloride Redi-Dri(TM), anhydrous, free-flowing, ACS reagent, >=99%;Sodium chloride Vetec(TM) reagent grade, 99%;BORIC ACID SODIUM DECAHYDRATE NF GRADE;BICINE HIGH PURITY GRADE
CAS: 7647-14-5
MF: NaCl
MW: 58.44277
EINECS: 231-598-3
Product Categories: Synthetic Reagents;SN - SZ;SN - SZCertified Reference Materials (CRMs);Alphabetic;Application CRMs;S;S - Z;Salt Solutions;Volumetric Solutions;Titrimetry;Titrimetry CRMs;TitrimetryAnalytical Standards;Reagents and Media SupplementsSynthetic Reagents;Specialty Media Systems;Inorganic Salts;ACS Grade BuffersBiological Buffers;ACS GradeBiological Buffers;Buffers A to ZSynthetic Reagents;Acids and BasesEssential Chemicals;Biochemicals and Reagents;Denaturation;Routine Reagents;Reagent Grade;Sodium Chloride (NaCl) and Sodium Chloride Solutions;Sodium Salts;Essential Chemicals;Inorganic Salts;Materials Science;Metal and Ceramic Science;Research Essentials;Analytical Reagents for General Use;HPLC;HPLC Buffer;HPLC Buffer - SolidChromatography/CE Reagents;HPLC Buffers;Solid;Anionic SolutionsChromatography;Anionic Standard SolutionsAlphabetic;C;CH;Ion Chromatography;Ion Chromatography Standards;Biotechnology Performance Certified (BPC) BuffersBiological Buffers;Buffer Convenience Packaging;Buffer SolutionsBiological Buffers;Buffers A to ZEssential Chemicals;Reagent Plus;Buffers A to ZSerum-free Media;Companion Products and ReagentsSynthetic Reagents;Insect Platform;Concentrates (e.g. FIXANAL);Reference Material Silver nitrateTitration;Accessories;AlphabeticalMolecular Biology;BioUltraProtein Structural Analysis;DNA&RNA Purification;Optimization ReagentsMolecular Biology;Biological Buffers;Solutions and Reagents;Crystal Grade Inorganics;Sodium;Ultra-High Purity Materials;Inorganics;Chemistry;Embryo Culture;Analytical Reagents;Atomic Absorption Spectroscopy (AAS);Digestion Reagents;Pure Salts for Melting Digestions (Trace SELECT)Analytical/Chromatography;Trace Analysis Reagents;Puriss p.a.;Q-S, Puriss p.a.;Acids and BasesBiological Buffers;Buffers A to ZBiological Buffers;SigmaUltra Buffers;Acids and BasesCell Culture;Biological BuffersBiological Buffers;Reagents and Supplements;IR Spectroscopy ReagentsMetal and Ceramic Science;IR Spectroscopy;Salts;Sodium Salts;Spectroscopy;Analytical/Chromatography;Auxiliaries for ISE;Ion Sensor Materials;Buffers A to ZHIS-Select;Reagents and Products for use with HIS-SelectSynthetic Reagents;Acids and BasesMolecular Biology;BiochemicalsBiological Buffers;HIS Select Supporting Products and Reagents;Molecular Biology Reagents;Crystal Grade Inorganics;Metal and Ceramic Science;SodiumMetal and Ceramic Science;Optimization ReagentsBiochemicals and Reagents;AlphabeticalProtein Structural Analysis;Density Gradient;Salts of Alkali Metals;X-Ray Crystallography;Reference Material Silver nitrateVolumetric Solutions;S - ZSynthetic Reagents;By Reference Material;Buffer TabletsBiological Buffers;Buffers A to Z;Reagent GradeMetal and Ceramic Science;Buffers A to ZPharmacopoeia (USP);Pharmacopoeia A-ZPharmacopoeia (USP);Pharmacopoeial InorganicsBiological Buffers;USP/MultiCompendial Grade Buffers;Salt Concentrates;ReagentsBiochemicals and Reagents;PurissSynthetic Reagents;Salts of Alkali MetalsMore...Close...;Acids and BasesBiochemicals and Reagents;AlphabeticalBiochemicals and Reagents;BioUltraMolecular Biology;metal halide
Mol File: 7647-14-5.mol
Sodium chloride Structure
 
Sodium chloride Chemical Properties
Melting point  801 °C (lit.)
Boiling point  1465 °C/1 atm (lit.)
density  1.199 g/mL at 20 °C
vapor pressure  1 mm Hg ( 865 °C)
refractive index  n20/D 1.378
Fp  1413°C
storage temp.  +15C to +30C
solubility  H2O: soluble
form  tablets
color  White
Specific Gravity 2.165
PH 5.5-6.5(1 tablet in 100 mL purified water)
Water Solubility  360 g/L (20 ºC)
Sensitive  Hygroscopic
λmax λ: 260 nm Amax: 0.02
λ: 280 nm Amax: 0.01
Merck  14,8599
BRN  3534976
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey FAPWRFPIFSIZLT-UHFFFAOYSA-M
CAS DataBase Reference 7647-14-5(CAS DataBase Reference)
NIST Chemistry Reference Sodium chloride(7647-14-5)
EPA Substance Registry System Sodium chloride (7647-14-5)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36-36/37/38-22
Safety Statements  24/25-26-36
WGK Germany  1
RTECS  VZ4725000
3-10
TSCA  Yes
HS Code  38220000
Hazardous Substances Data 7647-14-5(Hazardous Substances Data)
Toxicity LD50 orally in rats: 3.75 ±0.43 g/kg (Boyd, Shanas)
MSDS Information
Provider Language
Sodium chloride English
ACROS English
SigmaAldrich English
ALFA English
 
Sodium chloride Usage And Synthesis
Description Sodium chloride is widely distributed in nature. Oceans are the vast source of sodium chloride. It occurs in seawater at an average concentration of 2.68 wt%. It also occurs in many inland saline waters and in salt deposits in sedimentary rocks, as the mineral halite.
Sodium chloride is probably the most important salt of both sodium and chlorine. Sodium chloride, common table salt, is an essential component of most food preparation, imparting flavor to food and providing the sodium nutritional requirement. Also, it is used for preserving food. Therapeutically, NaCl solution is used to combat dehydration as an electrolyte replenisher, and it is an emetic.
The most important applications of sodium chloride in the chemical industry are in making a number of important industrial chemicals such as hydrochloric acid, sodium hydroxide, sodium carbonate, and metallic sodium. It is the starting material in manufacturing these substances. Other uses are in dyeing and printing fabrics, glazing pottery, in making soap, and for curing hides. Sodium chloride is a component of many freezing mixtures.
Chemical Properties Sodium chloride, NaCl, also known as common salt and halite, is a white crystalline solid.It is soluble in water,slightly soluble in alcohol, and melts at 804 °C (1480 °F). Sodium chloride is the most important sodium mineral and occurs naturally in seawater, underground deposits, and brine wells.Sodiumchlorideis a basic raw material for the production of chlorine,sodium hypochlorite, sodium bisulfate,soda ash, and hydrogen chloride. Sodium chloride is also used in food preparation, fertilizers, and by highway departments to control icy road conditions.
Chemical Properties Sodium chloride occurs as a white crystalline powder or colorless crystals; it has a saline taste. The crystal lattice is a face-centered cubic structure. Solid sodium chloride contains no water of crystallization although, below 0℃, salt may crystallize as a dihydrate.
Physical properties Sodium chloride is the familiar compound commonly referred to as salt or table salt. Th e mineral form of sodium chloride is halite and is found in natural deposits throughout the world. It accounts for approximately 2.7% by weight of the dissolved minerals in seawater. Sodium chloride is an ionic compound existing as a white crystalline cubic structure of alternating sodium and chloride ions. Sodium chloride is essential for life, with the average adult requiring about 1 to 2 grams per day. Salt supplies sodium and provides numerous essential functions such as maintaining water balance in cells, taking part in nerve signal transmission and muscle contraction.
Occurrence Sodium chloride is widely distributed in nature. Oceans are the vast source of sodium chloride. It occurs in seawater at an average concentration of 2.68 wt%. It also occurs in many inland saline waters and in salt deposits in sedimentary rocks, as the mineral halite.
Sodium chloride is probably the most important salt of both sodium and chlorine. Sodium chloride, common table salt, is an essential component of most food preparation, imparting flavor to food and providing the sodium nutritional requirement. Also, it is used for preserving food. Therapeutically, NaCl solution is used to combat dehydration as an electrolyte replenisher, and it is an emetic.
The most important applications of sodium chloride in the chemical industry are in making a number of important industrial chemicals such as hydrochloric acid, sodium hydroxide, sodium carbonate, and metallic sodium. It is the starting material in manufacturing these substances. Other uses are in dyeing and printing fabrics, glazing pottery, in making soap, and for curing hides. Sodium chloride is a component of many freezing mixtures.
Uses Facilitates the cross-coupling of organostannanes with iodides without using palladium.1
Uses Used in biochemistry and molecular biology applications; a component of PBS and SSC buffers
Uses Natural salt is the source of chlorine and of sodium as well as of all, or practically all, their Compounds, e.g., hydrochloric acid, chlorates, sodium carbonate, hydroxide, etc.; for preserving foods; manufacture of soap, to salt out dyes; in freezing mixtures; for dyeing and printing fabrics, glazing pottery, curing hides; metallurgy of tin and other metals.
Uses Used as an electrolyte; buffers ; matrix modification.
Uses sodium chloride (table salt) is used as a preservative, astringent, and anti-septic to treat inflamed lesions. It can also be used to mask odor, reduce product density, and control viscosity. Diluted solutions are not considered irritating.
Uses Sodium chloride Commonly known as table salt, sodium chloride is found as the mineral halite and in brines and seawater. Sodium chloride is soluble in water but less so in alcohol. It was the first halide to be combined with silver nitrate and was also used by L. J. M. Daguerre and W. H. F. Talbot as a stabilizer before fi xing with hypo was adopted.
Definition ChEBI: An inorganic chloride salt having sodium(1+) as the counterion.
Preparation Sodium chloride is produced by solar evaporation of seawater or brine from underground salt deposits. It also is produced by mining rock salt. The commercial product contains small amounts of calcium and magnesium chlorides.
Production Methods Sodium chloride occurs naturally as the mineral halite. Commercially, it is obtained by the solar evaporation of sea water, by mining, or by the evaporation of brine from underground salt deposits.
Definition A compound with an acidic and a basic radical, or a compound formed by total or partial replacement of the hydrogen in an acid by a metal. In general terms a salt is a material that has identifiable cationic and anionic components.
Definition saline: Describing a chemical compoundthat is a salt, or a solutioncontaining a salt.
Definition salt: A compound formed by reactionof an acid with a base, in whichthe hydrogen of the acid has been replacedby metal or other positiveions. Typically, salts are crystallineionic compounds such as Na+Cl– andNH4+NO3-. Covalent metal compounds,such as TiCl4, are also oftenregarded as salts.
Brand name Broncho Saline (Blairex).
General Description A white crystalline solid. Commercial grade usually contains some chlorides of calcium and magnesium which absorb moisture and cause caking.
Air & Water Reactions Water soluble.
Reactivity Profile Sodium chloride is generally unreactive. Releases gaseous hydrogen chloride if mixed with a concentrated nonvolatile acid such as sulfuric acid.
Fire Hazard Literature sources indicate that Sodium chloride is nonflammable.
Agricultural Uses Halite is a naturally occurring sodium chloride (NaCl) deposit. The most abundant potash mineral deposit is sylvite (KCl). Sylvite with halite forms the common potash ore, called sylvinite.
Pharmaceutical Applications Sodium chloride is widely used in a variety of parenteral and nonparenteral pharmaceutical formulations, where the primary use is to produce isotonic solutions.
Sodium chloride has been used as a lubricant and diluent in capsules and direct-compression tablet formulations in the past, although this practice is no longer common. Sodium chloride has also been used as a channeling agent and as an osmotic agent in the cores of controlled-release tablets. It has been used as a porosity modifier in tablet coatings, and to control drug release from microcapsules.
The addition of sodium chloride to aqueous spray-coating solutions containing hydroxypropyl cellulose or hypromellose suppresses the agglomeration of crystalline cellulose particles.(13) Sodium chloride can also be used to modify drug release from gels and from emulsions. It can be used to control micelle size, and to adjust the viscosity of polymer dispersions by altering the ionic character of a formulation.
Biochem/physiol Actions Sodium chloride helps to stimulate the stable induction of T-helper cell 17 (TH17) cells.
Clinical Use Treatment and prophylaxis of sodium chloride deficiency
Safety Profile Poison by intraperitoneal and intracervical routes. Moderately toxic by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: blood pressure increase. Human reproductive effects by intraplacental route: terminates pregnancy. Experimental reproductive effects. Human mutation data reported. A skin and eye irritant. When bulk sodium chloride is heated to high temperature, a vapor is emitted that is irritating, particularly to the eyes. Ingestion of large amounts of sodium chloride can cause irritation of the stomach. Improper use of salt tablets may produce this effect. Potentially explosive reaction with dichloromaleic anhydride + urea. Electrolysis of mixtures with nitrogen compounds may form the explosive nitrogen trichloride. Reaction with burning lithmm forms the dangerously reactive sodmm. The molten salt at 11 00' reacts explosively with water. Violent reaction with BrF3. When heated to decomposition it emits toxic fumes of Cland Na2O.
Safety Sodium chloride is the most important salt in the body for maintaining the osmotic tension of blood and tissues. About 5–12 g of sodium chloride is consumed daily, in the normal adult diet, and a corresponding amount is excreted in the urine. As an excipient, sodium chloride may be regarded as an essentially nontoxic and nonirritant material. However, toxic effects following the oral ingestion of 0.5–1.0 g/kg body-weight in adults may occur. The oral ingestion of larger quantities of sodium chloride, e.g. 1000 g in 600mL of water, is harmful and can induce irritation of the gastrointestinal tract, vomiting, hypernatremia, respiratory distress, convulsions, or death.
In rats, the minimum lethal intravenous dose is 2.5 g/kg bodyweight.
LD50 (mouse, IP): 6.61 g/kg
LD50 (mouse, IV): 0.65 g/kg
LD50 (mouse, oral): 4.0 g/kg
LD50 (mouse, SC): 3.0 g/kg
LD50 (rat, oral): 3.0 g/kg
Drug interactions Potentially hazardous interactions with other drugs
May impair the efficacy of antihypertensive drugs in chronic renal failure.
Metabolism Excess sodium is mainly excreted by the kidney, and small amounts are lost in the faeces and sweat.
storage Aqueous sodium chloride solutions are stable but may cause the separation of glass particles from certain types of glass containers. Aqueous solutions may be sterilized by autoclaving or filtration. The solid material is stable and should be stored in a well-closed container, in a cool, dry place.
It has been shown that the compaction characteristics and the mechanical properties of tablets are influenced by the relative humidity of the storage conditions under which sodium chloride was kept.
Purification Methods It is recrystallised from a saturated aqueous solution (2.7mL/g) by passing in HCl gas, or by adding EtOH or acetone. It can be freed from bromide and iodide impurities by adding chlorine water to an aqueous solution and boiling it for some time to expel free bromine and iodine. Traces of iron can be removed by prolonged boiling of solid NaCl in 6M HCl; the crystals are then washed with EtOH and dried at ca 100o. Sodium chloride has been purified by sublimation in a stream of pre-purified N2 and collected by electrostatic discharge [Ross & Winkler J Am Chem Soc 76 2637 1954]. For use as a primary analytical standard, analytical reagent grade NaCl should be finely ground, dried in an electric furnace at 500-600o in a platinum crucible, and allowed to cool in a desiccator. For most purposes, however, drying at 110-120o is satisfactory.
Incompatibilities Aqueous sodium chloride solutions are corrosive to iron. They also react to form precipitates with silver, lead, and mercury salts. Strong oxidizing agents liberate chlorine from acidified solutions of sodium chloride. The solubility of the antimicrobial preservative methylparaben is decreased in aqueous sodium chloride solutions and the viscosity of carbomer gels and solutions of hydroxyethyl cellulose or hydroxypropyl cellulose is reduced by the addition of sodium chloride.
Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (injections; inhalations; nasal, ophthalmic, oral, otic, rectal, and topical preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
 
Sodium chloride Preparation Products And Raw materials
Raw materials Potassium chloride-->Tetrapotassium hexacyanoferrate trihydrate-->Potassium ferrocyanide trihyrate-->Potassium iodate
Preparation Products Black cyanide-->1-METHYL-4-(3-NITROPHENYL)PIPERAZINE-->(S)-(+)-Methyl mandelate-->2-Amino-1,4-benzenedisulfonic acid-->2-Amino-5-chlorobenzotrifluoride-->Montelukast-->Gongzhulingmeisu-->N-Phenylhydroxylamine-->4-Chloro-3-methylpyridine-->5-Fluoro-2-methylbenzaldehyde-->Mordant Yellow 10-->1-METHYL-4-(4-NITROBENZYL)PIPERAZINE-->ACID YELLOW 11-->Acid Black 107-->2-Amino-5-chloro-4-methylbenzenesulfonic acid-->2,3,4,5-TETRAFLUORO-6-NITROBENZOIC ACID-->3-AMINO-5-BROMO-PYRIDIN-2-OL-->Copper, 2,2'-[carbonylbis[imino(1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis[benzoic acid] complex-->Urokinase-->Acid Green 28-->Propyl acetate-->Solvent Violet 8-->Cefepime-->Hydrogenated castor oil-->Chlorine dioxide,stable-->CHLOROFORMAMIDINE HYDROCHLORIDE-->TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE-->8-Amino-1-naphthol-3,6-disulfonic acid monosodium salt monohydrate-->SODA ASH LIGHT 99.2% MIN.-->Disperse Red 74-->Ficin froM Fig Tree Latex-->MERCUROUS CHLORIDE-->Dregs remover-->3-Hydroxynaphthalene-2,7-disulphonic acid-->Triethylenetetramine Dihydrochloride-->Direct Blue 199-->Stannous pyrophosphate-->fossil salt-->Ammonium chlorate-->2-[[(2-ethylphenyl)(2-hydroxyethyl)amino]methyl]-3,3-difluoro-Propanenitrile


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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Sodium chloride Basic information
Product Name: Sodium chloride
Synonyms: Sodium chloride puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., >=99.5%;Sodium chloride puriss., meets analytical specification of Ph. Eur., BP, USP, 99.0-100.5% (calc. to the dried substance), <=0.00002% Al;Sodium chloride random crystals, optical grade, 99.98% trace metals basis;Sodium chloride ReagentPlus(R), >=99%;Sodium chloride Redi-Dri(TM), anhydrous, free-flowing, ACS reagent, >=99%;Sodium chloride Vetec(TM) reagent grade, 99%;BORIC ACID SODIUM DECAHYDRATE NF GRADE;BICINE HIGH PURITY GRADE
CAS: 7647-14-5
MF: NaCl
MW: 58.44277
EINECS: 231-598-3
Product Categories: Synthetic Reagents;SN - SZ;SN - SZCertified Reference Materials (CRMs);Alphabetic;Application CRMs;S;S - Z;Salt Solutions;Volumetric Solutions;Titrimetry;Titrimetry CRMs;TitrimetryAnalytical Standards;Reagents and Media SupplementsSynthetic Reagents;Specialty Media Systems;Inorganic Salts;ACS Grade BuffersBiological Buffers;ACS GradeBiological Buffers;Buffers A to ZSynthetic Reagents;Acids and BasesEssential Chemicals;Biochemicals and Reagents;Denaturation;Routine Reagents;Reagent Grade;Sodium Chloride (NaCl) and Sodium Chloride Solutions;Sodium Salts;Essential Chemicals;Inorganic Salts;Materials Science;Metal and Ceramic Science;Research Essentials;Analytical Reagents for General Use;HPLC;HPLC Buffer;HPLC Buffer - SolidChromatography/CE Reagents;HPLC Buffers;Solid;Anionic SolutionsChromatography;Anionic Standard SolutionsAlphabetic;C;CH;Ion Chromatography;Ion Chromatography Standards;Biotechnology Performance Certified (BPC) BuffersBiological Buffers;Buffer Convenience Packaging;Buffer SolutionsBiological Buffers;Buffers A to ZEssential Chemicals;Reagent Plus;Buffers A to ZSerum-free Media;Companion Products and ReagentsSynthetic Reagents;Insect Platform;Concentrates (e.g. FIXANAL);Reference Material Silver nitrateTitration;Accessories;AlphabeticalMolecular Biology;BioUltraProtein Structural Analysis;DNA&RNA Purification;Optimization ReagentsMolecular Biology;Biological Buffers;Solutions and Reagents;Crystal Grade Inorganics;Sodium;Ultra-High Purity Materials;Inorganics;Chemistry;Embryo Culture;Analytical Reagents;Atomic Absorption Spectroscopy (AAS);Digestion Reagents;Pure Salts for Melting Digestions (Trace SELECT)Analytical/Chromatography;Trace Analysis Reagents;Puriss p.a.;Q-S, Puriss p.a.;Acids and BasesBiological Buffers;Buffers A to ZBiological Buffers;SigmaUltra Buffers;Acids and BasesCell Culture;Biological BuffersBiological Buffers;Reagents and Supplements;IR Spectroscopy ReagentsMetal and Ceramic Science;IR Spectroscopy;Salts;Sodium Salts;Spectroscopy;Analytical/Chromatography;Auxiliaries for ISE;Ion Sensor Materials;Buffers A to ZHIS-Select;Reagents and Products for use with HIS-SelectSynthetic Reagents;Acids and BasesMolecular Biology;BiochemicalsBiological Buffers;HIS Select Supporting Products and Reagents;Molecular Biology Reagents;Crystal Grade Inorganics;Metal and Ceramic Science;SodiumMetal and Ceramic Science;Optimization ReagentsBiochemicals and Reagents;AlphabeticalProtein Structural Analysis;Density Gradient;Salts of Alkali Metals;X-Ray Crystallography;Reference Material Silver nitrateVolumetric Solutions;S - ZSynthetic Reagents;By Reference Material;Buffer TabletsBiological Buffers;Buffers A to Z;Reagent GradeMetal and Ceramic Science;Buffers A to ZPharmacopoeia (USP);Pharmacopoeia A-ZPharmacopoeia (USP);Pharmacopoeial InorganicsBiological Buffers;USP/MultiCompendial Grade Buffers;Salt Concentrates;ReagentsBiochemicals and Reagents;PurissSynthetic Reagents;Salts of Alkali MetalsMore...Close...;Acids and BasesBiochemicals and Reagents;AlphabeticalBiochemicals and Reagents;BioUltraMolecular Biology;metal halide
Mol File: 7647-14-5.mol
Sodium chloride Structure
 
Sodium chloride Chemical Properties
Melting point  801 °C (lit.)
Boiling point  1465 °C/1 atm (lit.)
density  1.199 g/mL at 20 °C
vapor pressure  1 mm Hg ( 865 °C)
refractive index  n20/D 1.378
Fp  1413°C
storage temp.  +15C to +30C
solubility  H2O: soluble
form  tablets
color  White
Specific Gravity 2.165
PH 5.5-6.5(1 tablet in 100 mL purified water)
Water Solubility  360 g/L (20 ºC)
Sensitive  Hygroscopic
λmax λ: 260 nm Amax: 0.02
λ: 280 nm Amax: 0.01
Merck  14,8599
BRN  3534976
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey FAPWRFPIFSIZLT-UHFFFAOYSA-M
CAS DataBase Reference 7647-14-5(CAS DataBase Reference)
NIST Chemistry Reference Sodium chloride(7647-14-5)
EPA Substance Registry System Sodium chloride (7647-14-5)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36-36/37/38-22
Safety Statements  24/25-26-36
WGK Germany  1
RTECS  VZ4725000
3-10
TSCA  Yes
HS Code  38220000
Hazardous Substances Data 7647-14-5(Hazardous Substances Data)
Toxicity LD50 orally in rats: 3.75 ±0.43 g/kg (Boyd, Shanas)
MSDS Information
Provider Language
Sodium chloride English
ACROS English
SigmaAldrich English
ALFA English
 
Sodium chloride Usage And Synthesis
Description Sodium chloride is widely distributed in nature. Oceans are the vast source of sodium chloride. It occurs in seawater at an average concentration of 2.68 wt%. It also occurs in many inland saline waters and in salt deposits in sedimentary rocks, as the mineral halite.
Sodium chloride is probably the most important salt of both sodium and chlorine. Sodium chloride, common table salt, is an essential component of most food preparation, imparting flavor to food and providing the sodium nutritional requirement. Also, it is used for preserving food. Therapeutically, NaCl solution is used to combat dehydration as an electrolyte replenisher, and it is an emetic.
The most important applications of sodium chloride in the chemical industry are in making a number of important industrial chemicals such as hydrochloric acid, sodium hydroxide, sodium carbonate, and metallic sodium. It is the starting material in manufacturing these substances. Other uses are in dyeing and printing fabrics, glazing pottery, in making soap, and for curing hides. Sodium chloride is a component of many freezing mixtures.
Chemical Properties Sodium chloride, NaCl, also known as common salt and halite, is a white crystalline solid.It is soluble in water,slightly soluble in alcohol, and melts at 804 °C (1480 °F). Sodium chloride is the most important sodium mineral and occurs naturally in seawater, underground deposits, and brine wells.Sodiumchlorideis a basic raw material for the production of chlorine,sodium hypochlorite, sodium bisulfate,soda ash, and hydrogen chloride. Sodium chloride is also used in food preparation, fertilizers, and by highway departments to control icy road conditions.
Chemical Properties Sodium chloride occurs as a white crystalline powder or colorless crystals; it has a saline taste. The crystal lattice is a face-centered cubic structure. Solid sodium chloride contains no water of crystallization although, below 0℃, salt may crystallize as a dihydrate.
Physical properties Sodium chloride is the familiar compound commonly referred to as salt or table salt. Th e mineral form of sodium chloride is halite and is found in natural deposits throughout the world. It accounts for approximately 2.7% by weight of the dissolved minerals in seawater. Sodium chloride is an ionic compound existing as a white crystalline cubic structure of alternating sodium and chloride ions. Sodium chloride is essential for life, with the average adult requiring about 1 to 2 grams per day. Salt supplies sodium and provides numerous essential functions such as maintaining water balance in cells, taking part in nerve signal transmission and muscle contraction.
Occurrence Sodium chloride is widely distributed in nature. Oceans are the vast source of sodium chloride. It occurs in seawater at an average concentration of 2.68 wt%. It also occurs in many inland saline waters and in salt deposits in sedimentary rocks, as the mineral halite.
Sodium chloride is probably the most important salt of both sodium and chlorine. Sodium chloride, common table salt, is an essential component of most food preparation, imparting flavor to food and providing the sodium nutritional requirement. Also, it is used for preserving food. Therapeutically, NaCl solution is used to combat dehydration as an electrolyte replenisher, and it is an emetic.
The most important applications of sodium chloride in the chemical industry are in making a number of important industrial chemicals such as hydrochloric acid, sodium hydroxide, sodium carbonate, and metallic sodium. It is the starting material in manufacturing these substances. Other uses are in dyeing and printing fabrics, glazing pottery, in making soap, and for curing hides. Sodium chloride is a component of many freezing mixtures.
Uses Facilitates the cross-coupling of organostannanes with iodides without using palladium.1
Uses Used in biochemistry and molecular biology applications; a component of PBS and SSC buffers
Uses Natural salt is the source of chlorine and of sodium as well as of all, or practically all, their Compounds, e.g., hydrochloric acid, chlorates, sodium carbonate, hydroxide, etc.; for preserving foods; manufacture of soap, to salt out dyes; in freezing mixtures; for dyeing and printing fabrics, glazing pottery, curing hides; metallurgy of tin and other metals.
Uses Used as an electrolyte; buffers ; matrix modification.
Uses sodium chloride (table salt) is used as a preservative, astringent, and anti-septic to treat inflamed lesions. It can also be used to mask odor, reduce product density, and control viscosity. Diluted solutions are not considered irritating.
Uses Sodium chloride Commonly known as table salt, sodium chloride is found as the mineral halite and in brines and seawater. Sodium chloride is soluble in water but less so in alcohol. It was the first halide to be combined with silver nitrate and was also used by L. J. M. Daguerre and W. H. F. Talbot as a stabilizer before fi xing with hypo was adopted.
Definition ChEBI: An inorganic chloride salt having sodium(1+) as the counterion.
Preparation Sodium chloride is produced by solar evaporation of seawater or brine from underground salt deposits. It also is produced by mining rock salt. The commercial product contains small amounts of calcium and magnesium chlorides.
Production Methods Sodium chloride occurs naturally as the mineral halite. Commercially, it is obtained by the solar evaporation of sea water, by mining, or by the evaporation of brine from underground salt deposits.
Definition A compound with an acidic and a basic radical, or a compound formed by total or partial replacement of the hydrogen in an acid by a metal. In general terms a salt is a material that has identifiable cationic and anionic components.
Definition saline: Describing a chemical compoundthat is a salt, or a solutioncontaining a salt.
Definition salt: A compound formed by reactionof an acid with a base, in whichthe hydrogen of the acid has been replacedby metal or other positiveions. Typically, salts are crystallineionic compounds such as Na+Cl– andNH4+NO3-. Covalent metal compounds,such as TiCl4, are also oftenregarded as salts.
Brand name Broncho Saline (Blairex).
General Description A white crystalline solid. Commercial grade usually contains some chlorides of calcium and magnesium which absorb moisture and cause caking.
Air & Water Reactions Water soluble.
Reactivity Profile Sodium chloride is generally unreactive. Releases gaseous hydrogen chloride if mixed with a concentrated nonvolatile acid such as sulfuric acid.
Fire Hazard Literature sources indicate that Sodium chloride is nonflammable.
Agricultural Uses Halite is a naturally occurring sodium chloride (NaCl) deposit. The most abundant potash mineral deposit is sylvite (KCl). Sylvite with halite forms the common potash ore, called sylvinite.
Pharmaceutical Applications Sodium chloride is widely used in a variety of parenteral and nonparenteral pharmaceutical formulations, where the primary use is to produce isotonic solutions.
Sodium chloride has been used as a lubricant and diluent in capsules and direct-compression tablet formulations in the past, although this practice is no longer common. Sodium chloride has also been used as a channeling agent and as an osmotic agent in the cores of controlled-release tablets. It has been used as a porosity modifier in tablet coatings, and to control drug release from microcapsules.
The addition of sodium chloride to aqueous spray-coating solutions containing hydroxypropyl cellulose or hypromellose suppresses the agglomeration of crystalline cellulose particles.(13) Sodium chloride can also be used to modify drug release from gels and from emulsions. It can be used to control micelle size, and to adjust the viscosity of polymer dispersions by altering the ionic character of a formulation.
Biochem/physiol Actions Sodium chloride helps to stimulate the stable induction of T-helper cell 17 (TH17) cells.
Clinical Use Treatment and prophylaxis of sodium chloride deficiency
Safety Profile Poison by intraperitoneal and intracervical routes. Moderately toxic by ingestion, intravenous, and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: blood pressure increase. Human reproductive effects by intraplacental route: terminates pregnancy. Experimental reproductive effects. Human mutation data reported. A skin and eye irritant. When bulk sodium chloride is heated to high temperature, a vapor is emitted that is irritating, particularly to the eyes. Ingestion of large amounts of sodium chloride can cause irritation of the stomach. Improper use of salt tablets may produce this effect. Potentially explosive reaction with dichloromaleic anhydride + urea. Electrolysis of mixtures with nitrogen compounds may form the explosive nitrogen trichloride. Reaction with burning lithmm forms the dangerously reactive sodmm. The molten salt at 11 00' reacts explosively with water. Violent reaction with BrF3. When heated to decomposition it emits toxic fumes of Cland Na2O.
Safety Sodium chloride is the most important salt in the body for maintaining the osmotic tension of blood and tissues. About 5–12 g of sodium chloride is consumed daily, in the normal adult diet, and a corresponding amount is excreted in the urine. As an excipient, sodium chloride may be regarded as an essentially nontoxic and nonirritant material. However, toxic effects following the oral ingestion of 0.5–1.0 g/kg body-weight in adults may occur. The oral ingestion of larger quantities of sodium chloride, e.g. 1000 g in 600mL of water, is harmful and can induce irritation of the gastrointestinal tract, vomiting, hypernatremia, respiratory distress, convulsions, or death.
In rats, the minimum lethal intravenous dose is 2.5 g/kg bodyweight.
LD50 (mouse, IP): 6.61 g/kg
LD50 (mouse, IV): 0.65 g/kg
LD50 (mouse, oral): 4.0 g/kg
LD50 (mouse, SC): 3.0 g/kg
LD50 (rat, oral): 3.0 g/kg
Drug interactions Potentially hazardous interactions with other drugs
May impair the efficacy of antihypertensive drugs in chronic renal failure.
Metabolism Excess sodium is mainly excreted by the kidney, and small amounts are lost in the faeces and sweat.
storage Aqueous sodium chloride solutions are stable but may cause the separation of glass particles from certain types of glass containers. Aqueous solutions may be sterilized by autoclaving or filtration. The solid material is stable and should be stored in a well-closed container, in a cool, dry place.
It has been shown that the compaction characteristics and the mechanical properties of tablets are influenced by the relative humidity of the storage conditions under which sodium chloride was kept.
Purification Methods It is recrystallised from a saturated aqueous solution (2.7mL/g) by passing in HCl gas, or by adding EtOH or acetone. It can be freed from bromide and iodide impurities by adding chlorine water to an aqueous solution and boiling it for some time to expel free bromine and iodine. Traces of iron can be removed by prolonged boiling of solid NaCl in 6M HCl; the crystals are then washed with EtOH and dried at ca 100o. Sodium chloride has been purified by sublimation in a stream of pre-purified N2 and collected by electrostatic discharge [Ross & Winkler J Am Chem Soc 76 2637 1954]. For use as a primary analytical standard, analytical reagent grade NaCl should be finely ground, dried in an electric furnace at 500-600o in a platinum crucible, and allowed to cool in a desiccator. For most purposes, however, drying at 110-120o is satisfactory.
Incompatibilities Aqueous sodium chloride solutions are corrosive to iron. They also react to form precipitates with silver, lead, and mercury salts. Strong oxidizing agents liberate chlorine from acidified solutions of sodium chloride. The solubility of the antimicrobial preservative methylparaben is decreased in aqueous sodium chloride solutions and the viscosity of carbomer gels and solutions of hydroxyethyl cellulose or hydroxypropyl cellulose is reduced by the addition of sodium chloride.
Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (injections; inhalations; nasal, ophthalmic, oral, otic, rectal, and topical preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
 
Sodium chloride Preparation Products And Raw materials
Raw materials Potassium chloride-->Tetrapotassium hexacyanoferrate trihydrate-->Potassium ferrocyanide trihyrate-->Potassium iodate
Preparation Products Black cyanide-->1-METHYL-4-(3-NITROPHENYL)PIPERAZINE-->(S)-(+)-Methyl mandelate-->2-Amino-1,4-benzenedisulfonic acid-->2-Amino-5-chlorobenzotrifluoride-->Montelukast-->Gongzhulingmeisu-->N-Phenylhydroxylamine-->4-Chloro-3-methylpyridine-->5-Fluoro-2-methylbenzaldehyde-->Mordant Yellow 10-->1-METHYL-4-(4-NITROBENZYL)PIPERAZINE-->ACID YELLOW 11-->Acid Black 107-->2-Amino-5-chloro-4-methylbenzenesulfonic acid-->2,3,4,5-TETRAFLUORO-6-NITROBENZOIC ACID-->3-AMINO-5-BROMO-PYRIDIN-2-OL-->Copper, 2,2'-[carbonylbis[imino(1-hydroxy-3-sulfo-6,2-naphthalenediyl)azo]]bis[benzoic acid] complex-->Urokinase-->Acid Green 28-->Propyl acetate-->Solvent Violet 8-->Cefepime-->Hydrogenated castor oil-->Chlorine dioxide,stable-->CHLOROFORMAMIDINE HYDROCHLORIDE-->TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE-->8-Amino-1-naphthol-3,6-disulfonic acid monosodium salt monohydrate-->SODA ASH LIGHT 99.2% MIN.-->Disperse Red 74-->Ficin froM Fig Tree Latex-->MERCUROUS CHLORIDE-->Dregs remover-->3-Hydroxynaphthalene-2,7-disulphonic acid-->Triethylenetetramine Dihydrochloride-->Direct Blue 199-->Stannous pyrophosphate-->fossil salt-->Ammonium chlorate-->2-[[(2-ethylphenyl)(2-hydroxyethyl)amino]methyl]-3,3-difluoro-Propanenitrile

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