China Largest Manufacturer factory sales Choline Dihydrogencitrate salt CAS 77-91-8 CAS NO.77-91-8

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Choline dihydrogencitrate salt Basic information Product Name: Choline dihydrogencitrate salt Synonyms: Choline Citrate (1:1) (Salt);Cholinvel;Citracol;Colicitrin;Coline citrate;Coline dihydrogen citrate;Delichol;2-(carboxymethyl)-2,4-dihydroxy-4-keto-butyrate CAS: 77-91-8 MF: C6H7O7.C5H14NO MW: 295.29 EINECS: 201-068-6 Product Categories: Biochemistry;Vitamin Related Compounds;Vitamins Mol File: 77-91-8.mol   Choline dihydrogencitrate salt Chemical Properties Melting point  105-107.5° storage temp.  2-8°C solubility  DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly) form  Solid color  White to Off-White Water Solubility  almost transparency Merck  14,2207 Stability: Hygroscopic CAS DataBase Reference 77-91-8(CAS DataBase Reference) EPA Substance Registry System Choline citrate (1:1) (77-91-8)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26 WGK Germany  2 RTECS  GA2582000 HS Code  29231000 MSDS Information Provider Language SigmaAldrich English   Choline dihydrogencitrate salt Usage And Synthesis Chemical Properties White crystalline powder Originator Chothyn, Flint, US,1945 Uses Choline Dihydrogen Citrate can be used to synthesize compounds that can improve the photosynthetic efficiency of plants. It can also be used for synthesizing cleaning compounds that can be used for dishwashing, oven cleaning, microwave oven cleaning, floor cleaning, or surface cleaning. Furthermore, Choline Dihydrogen Citrate can potentially be used in the treatment of multiple sclerosis. Additionally, Choline Dihydrogen Citrate can also be use as a component of a nutritional supplement that can be used for improving cerebral activity. Manufacturing Process 30 lb of trimethylamine were added to 70.4 lb of methyl alcohol to which 9.2 lb of water had previously been added. To the resulting solution in a closed vessel 23 lb of ethylene oxide gas were introduced and the resulting mixture then maintained at a temperature of 16 C to 30 C and agitated for 6 hours. During the reaction the pressure in the reaction vessel varied from about 17.5 psi at the start of the reaction to 0 psi at the end of the reaction. The resulting solution was then added with agitation to a refluxing solution of 40 liters of isopropyl alcohol containing 95 lb of citric acid dissolved therein. This mixture was then cooled to 0°C and held at that temperature overnight. The white crystalline choline dihydrogen citrate which formed was separated from the solvent mixture by filtration and dried in vacuo. 117 lb of anhydrous, crystalline choline dihydrogen citrate having a purity of 99.6% were obtained. This was a yield of 78% based on the amount of trimethylamine employed. Therapeutic Function Lipotropic Biochem/physiol Actions Acyl group acceptor   Choline dihydrogencitrate salt Preparation Products And Raw materials Raw materials Citric acid-->Trimethylamine-->ETHYLENE OXIDE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Choline dihydrogencitrate salt Basic information Product Name: Choline dihydrogencitrate salt Synonyms: Choline Citrate (1:1) (Salt);Cholinvel;Citracol;Colicitrin;Coline citrate;Coline dihydrogen citrate;Delichol;2-(carboxymethyl)-2,4-dihydroxy-4-keto-butyrate CAS: 77-91-8 MF: C6H7O7.C5H14NO MW: 295.29 EINECS: 201-068-6 Product Categories: Biochemistry;Vitamin Related Compounds;Vitamins Mol File: 77-91-8.mol   Choline dihydrogencitrate salt Chemical Properties Melting point  105-107.5° storage temp.  2-8°C solubility  DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly) form  Solid color  White to Off-White Water Solubility  almost transparency Merck  14,2207 Stability: Hygroscopic CAS DataBase Reference 77-91-8(CAS DataBase Reference) EPA Substance Registry System Choline citrate (1:1) (77-91-8)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26 WGK Germany  2 RTECS  GA2582000 HS Code  29231000 MSDS Information Provider Language SigmaAldrich English   Choline dihydrogencitrate salt Usage And Synthesis Chemical Properties White crystalline powder Originator Chothyn, Flint, US,1945 Uses Choline Dihydrogen Citrate can be used to synthesize compounds that can improve the photosynthetic efficiency of plants. It can also be used for synthesizing cleaning compounds that can be used for dishwashing, oven cleaning, microwave oven cleaning, floor cleaning, or surface cleaning. Furthermore, Choline Dihydrogen Citrate can potentially be used in the treatment of multiple sclerosis. Additionally, Choline Dihydrogen Citrate can also be use as a component of a nutritional supplement that can be used for improving cerebral activity. Manufacturing Process 30 lb of trimethylamine were added to 70.4 lb of methyl alcohol to which 9.2 lb of water had previously been added. To the resulting solution in a closed vessel 23 lb of ethylene oxide gas were introduced and the resulting mixture then maintained at a temperature of 16 C to 30 C and agitated for 6 hours. During the reaction the pressure in the reaction vessel varied from about 17.5 psi at the start of the reaction to 0 psi at the end of the reaction. The resulting solution was then added with agitation to a refluxing solution of 40 liters of isopropyl alcohol containing 95 lb of citric acid dissolved therein. This mixture was then cooled to 0°C and held at that temperature overnight. The white crystalline choline dihydrogen citrate which formed was separated from the solvent mixture by filtration and dried in vacuo. 117 lb of anhydrous, crystalline choline dihydrogen citrate having a purity of 99.6% were obtained. This was a yield of 78% based on the amount of trimethylamine employed. Therapeutic Function Lipotropic Biochem/physiol Actions Acyl group acceptor   Choline dihydrogencitrate salt Preparation Products And Raw materials Raw materials Citric acid-->Trimethylamine-->ETHYLENE OXIDE