China Largest Factory Manufacturer sales Sodium sulfite CAS7757-83-7 CAS NO.7757-83-7

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Sodium sulfite Basic information Description Uses References Product Name: Sodium sulfite Synonyms: anhydroussodiumsulfite;disodiumsulfite;exsiccatedsodiumsulfite;natriisulphis;natriumsulfid;natriumsulfit;natriumsulfurosum;sodiumsulfite(2:1) CAS: 7757-83-7 MF: Na2O3S MW: 126.04 EINECS: 231-821-4 Product Categories: Paper, glass, printing and dyeing;inorganic compound;Inorganic Chemicals;Inorganics;Analytical Reagents for General Use;Puriss p.a.;Essential Chemicals;Inorganic Salts;Synthetic Reagents;Disulfide Bridge Cleavage Reagents;AlphabeticalBiochemicals and Reagents;Biochemicals and Reagents;Denaturation;Q-S, Puriss p.a.;Water Ttreatment Chemicals;Reagent Grade;Routine Reagents;Disulfide Bridge Cleavage ReagentsSynthetic Reagents;ACS GradeBiochemicals and Reagents Mol File: 7757-83-7.mol   Sodium sulfite Chemical Properties Melting point  500 °C density  2.63 refractive index  1,484 storage temp.  Store at +5°C to +30°C. solubility  H2O: 1 M at 20 °C, clear, colorless form  Solid Specific Gravity 2.633 color  White to slightly yellow Odor Odorless PH Range 9.0 - 10.5 at 126 g/l at 25 °C PH 9.0-10.5 (25℃, 1M in H2O) Water Solubility  23 g/100 mL (20 ºC) Sensitive  Hygroscopic Merck  14,8682 Stability: Stable. Incompatible with strong acids. Moisture and air sensitive. CAS DataBase Reference 7757-83-7(CAS DataBase Reference) NIST Chemistry Reference sodium sulfite(7757-83-7) EPA Substance Registry System Sodium sulfite (7757-83-7)   Safety Information Hazard Codes  Xn Risk Statements  31-36/37/38-22-40-36/38 Safety Statements  24/25-36-26-22 WGK Germany  1 RTECS  WE2150000 F  3-10 TSCA  Yes HS Code  28321000 Hazardous Substances Data 7757-83-7(Hazardous Substances Data) Toxicity LD50 i.v. in mice: 175 mg/kg, Hoppe, Goble, J. Pharmacol. Exp. Ther. 101, 101 (1951) MSDS Information Provider Language Sodium sulfite English SigmaAldrich English ACROS English ALFA English   Sodium sulfite Usage And Synthesis Description As a soluble sodium salt of sulfurous acid, Sodium sulfite (Na2SO3) shows blenching, de-sulfurizing and dechlorinating properties which is widely applied in various fields. It is primarily used in the pulp and papermaking industry due to its blenching activity. It can serve as a good additive to help preserve the fresh appearance of good products. Besides, sodium sulfite is a component in many pharmaceuticals, which is effective to maintain the potency and stability of drugs. It can also be applied for water treatment as an oxygen scavenger agent and applied in flue gas desulfurization and preservation of photo developer solutions, etc. Uses Sodium sulfite (Na2SO3) is an antioxidant, used as a preservative except with meats. It is also used for water treatment and in photography and textile bleaching. References # # # # Chemical Properties Sodium sulfite occurs as an odorless white powder or hexagonal prisms. Note that the commercially available sodium sulfite is often presented as a white to tan- or pink-colored powder that would not conform to the pharmacopeial specification. Chemical Properties Sodium sulfite,Na2S03, is a white,water-soluble, crystalline solid with a sulfurous, salty taste. It decomposes when heated. Sodium sulfite is used as a source of sulfite,as a chemical intermediate and food preservative, in medicine and paper manufacturing, in photographic developing, and as a bleaching agent in the textile industry. Most boiler operators use sodium sulfite for chemicals cavenging of oxygen in the feedwater. Because it decomposes into acidic gases at the high temperatures that accompany high pressures, sodium sulfite should not be used for this purpose at pressures above 122atm (12.4MPa,or 1.8 ksi). Chemical Properties Sodium sulfite is a white crystalline solid Uses sodium sulfite has anti-septic, preservative, and anti-oxidant properties. Sodium sulfite is also a topical anti-fungal. Uses These white crystals were prepared by passing sulfurous gas over moist sodium carbonate. Sodium sulfite is soluble in water but less so in alcohol. It was used as a preservative for alkaline developers and as a hypo clearing agent in photographic printing. Uses Paper industry (semichemical pulp), reduc- ing agent (dyes), water treatment, photographic developer, food preservative and antioxidant, tex- tile bleaching (antichlor). Definition ChEBI: An inorganic sodium salt having sulfite as the counterion. Production Methods Sodium bisulfite is prepared by reacting sulfur dioxide gas with sodium hydroxide solution. The solid material is obtained by evaporation of water. Further neutralization with sodium hydroxide while keeping the temperature above 33.6°C leads to crystallization of the anhydrous sodium sulfite (below this temperature the heptahydrate form is obtained). Definition sodium sulphite: A white solid,Na2SO3, existing in an anhydrousform (r.d. 2.63) and as a heptahydrate(r.d. 1.59). Sodium sulphite is solublein water and because it is readily oxidizedit is widely used as a convenientreducing agent. It is preparedby reacting sulphur dioxide with eithersodium carbonate or sodium hydroxide.Dilute mineral acids reversethis process and release sulphur dioxide.Sodium sulphite is used as ableaching agent in textiles and inpaper manufacture. Its use as an antioxidantin some canned foodstuffsgives rise to a slightly sulphuroussmell immediately on opening, butits use is prohibited in meats or foodsthat contain vitamin B1. Sodium sulphitesolutions are occasionally usedas biological preservatives. General Description White odorless powder. Density 2.633 g / cm3. Moderately toxic. Sinks in water and dissolves slowly. Also transported as a heptahydrate Na2SO3.7H2O. Air & Water Reactions Soluble in water. Reacts with hot water, steam or acids to produce corrosive material. Reactivity Profile Sodium sulfite is a reducing agent, particularly under basic conditions. Reacts with oxidizing agents such as peroxides, epoxides, oxoacids. Emits toxic fumes of sodium oxide and oxides of sulfur if heated to decomposition [Lewis, 3rd ed., 1993, p. 1174]. Hazard Use prohibited in meats and other sources of Vitamin B 1 Health Hazard When ingested, solutions cause gastric irritation by the liberation of sulfurous acid. Because of rapid oxidation to sulfate, sulfites are well tolerated until large doses are reached; then violent colic and diarrhea, circulatory disturbances, central nervous depression, and death can occur. Fire Hazard Literature sources indicate that Sodium sulfite is noncombustible. Pharmaceutical Applications Sodium sulfite is used as an antioxidant in applications similar to those for sodium metabisulfite. It is also an effective antimicrobial preservative, particularly against fungi at low pH (0.1% w/v of sodium sulfite is used). Sodium sulfite is used in cosmetics, food products, and pharmaceutical applications such as parenteral formulations, inhalations, oral formulations, and topical preparations. Contact allergens Sodium sulfite is mainly used in photographic developers, for fixing prints, bleaching textile fibers, as a reducer in manufacturing dyes, as a remover of Cl in bleached textiles and paper, and as a preservative in the food industry for meat, egg yolks, and so on. Safety Profile Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Na2O and SOx. A reducing agent. See also SULFITES. Safety Sodium sulfite is widely used in food and pharmaceutical applications as an antioxidant. It is generally regarded as relatively nontoxic and nonirritant when used as an excipient. However, contact dermatitis and hypersensitivity reactions have been reported. The acceptable daily intake for sodium sulfite has been set at up to 350 mg/kg body-weight daily. LD50 (mouse, IP): 0.950 g/kg LD50 (mouse, IV): 0.130 g/kg LD50 (mouse, oral): 0.820 g/kg LD50 (rabbit, IV): 0.065 g/kg LD50 (rabbit, oral): 1.181 g/kg LD50 (rat, IV): 0.115 g/kg Potential Exposure Sodium sulfite is used as a reducing agent; in boiler water treatment; food applications; in photographic developers and fixers; in bleaching of wool, paper, textiles, straw and silk; manufacture of dyes; dechlorination; preservation of meat, fruit and egg products; silvering of glass. Environmental Fate Because sodium sulfite is a solid powder that is generally sold as a ‘food grade’ substance, there is very little information available on the environmental fate of sodium sulfite. It has a molecular weight of 126.04 g mol-1. At 20°C, the solubility in water is 250 000 mg l-1, and as it is an inorganic salt the vapor is negligible (USEPA, 2011). The log octanol/water partition coefficient is estimated to be 7.78. If released into water or soil, sodium sulfite would most likely be oxidized to sulfate, which would then be available for use by bacteria or plants as a nutrient. The US Environmental Protection Agency (EPA) EPI Suite computer program (USEPA, 2011) estimates both a bioconcentration factor and a bioaccumulation factor of 0.89. These factors are less than one, meaning that bioconcentration and/or bioaccumulation of sodium sulfite would be virtually negligible and therefore would not cause any adverse effects to fish and wildlife. storage Sodium sulfite should be stored in a well-closed container in a cool, dry, place. In solution, sodium sulfite is slowly oxidized to sulfate by dissolved oxygen; strong acids lead to formation of sulfurous acid/ sulfur dioxide. On heating, sodium sulfite decomposes liberating sulfur oxides. Shipping UN3260 Corrosive solid, acidic, inorganic, n.o.s., Hazard class: 8; Labels: 8-Corrosive material. Purification Methods Crystallise the sulfite from warm water (0.5mL/g) by cooling to 0o. Also purify it by repeated crystallisation from deoxygenated water inside a glove-box, and finally drying it under vacuum. [Rhee & Dasgupta J Phys Chem 89 1799 1985.] Toxicity evaluation The exact mechanism of toxicity has not been elucidated, although there is a lot of information on how sulfur-based compounds are detoxified by the liver. Sodium sulfite is a mild reducing agent that would most likely cause burning or irritation at the site of exposure or application by altering oxidation–reduction potential and pH. Sulfites are used widely as antioxidants to keep foods from prematurely spoiling and to keep them looking ‘fresh’ by preventing oxidation and subsequent ‘browning.’ Many people, however, are ‘sulfite sensitive.’ After ingestion of food or beverages containing sulfite, these people may have allergictype reactions such as asthmatic wheezing, hypotension, tingling sensations, and flushing of the skin. The mechanism is unclear but probably has to do with an individual-specific chemical stimulation of the immune system, which in turn releases small amounts of vasoactive substances. Incompatibilities Sodium sulfite is incompatible with acids, oxidizing agents, many proteins, and vitamin B1. Incompatibilities A strong reducing agent. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases. Reacts with strong acids producing toxic sulfur dioxide. Regulatory Status GRAS listed. Accepted for use as a food additive in Europe. Included in FDA Inactive Ingredients Database (epidural, IM, IV, and SC injections; inhalation solution; ophthalmic solutions; oral syrups and suspensions; otic solutions; topical creams and emulsions). Included in nonparenteral medicines licensed in the UK.   Sodium sulfite Preparation Products And Raw materials Raw materials Sodium hydroxide-->Sulfuric acid-->Sodium carbonate-->Benzene-->Sulfur-->Phenol-->Sodium dithionite-->Sodium sulfide-->Sulfur dioxide-->Sulphur-->Sodium sulfide nonahydrate-->SODIUM SULFITE HEPTAHYDRATE Preparation Products 1,8-DINITROANTHRAQUINONE-->Sodium 1-hexanesulfonate-->(3-TRIFLUOROMETHOXY-PHENYL)-HYDRAZINE HYDROCHLORIDE-->1-HEPTANESULFONIC ACID SODIUM SALT MONOHYDRATE-->3,3-Dimethylglutaric acid-->6-FLUORO-2-NAPHTHOIC ACID-->2-(4-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE-->3-Cyanophenylhydrazine hydrochloride-->Sodium pentanesulfonate-->Sodium 1-octanesulfonate-->Sodium decane-1-sulfonate-->2-(2-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE-->1-HEXADECANESULFONIC ACID SODIUM SALT-->2-BROMORESORCINOL-->Sodium 1-heptanesulfonate-->1-TRIDECANESULFONIC ACID SODIUM SALT-->1-TETRADECANESULFONIC ACID SODIUM SALT-->Sodium 1-butanesulfonate-->2-Bromo-6-fluoronaphthalene-->1-NONANESULFONIC ACID SODIUM SALT-->1-BUTANESULFONIC ACID SODIUM SALT MONOHYDRATE-->4-TRIFLUOROMETHYLBENZYLSULFONYL CHLORIDE-->1-Methyl-4-(methylsulfonyl)-benzene-->R-(-)-Apomorphine-->Sodium 2-bromoethanesulphonate-->friction reducer SAF-->acramoll W paste-->O-TOLYL-METHANESULFONYL CHLORIDE-->6-BROMONAPHTHALEN-2-AMINE-->M-TOLYL-METHANESULFONYL CHLORIDE-->2-Trifluoromethylbenzylsulfonyl chloride-->2-NITRO-ALPHA-TOLUENESULFONYL CHLORIDE-->(2-FLUORO-PHENYL)-METHANESULFONYL CHLORIDE-->Zonisamide-->N-(4-iodobenzoyl)-L-glutamic acid-->1,4-Butane sultone-->4-Iodoanisole-->2-METHYL-2-PROPENE-1-SULFONIC ACID SODIUM SALT-->HEPTALDEHYDE SODIUM BISULFITE-->Emulsifier OS

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Sodium sulfite Basic information Description Uses References Product Name: Sodium sulfite Synonyms: anhydroussodiumsulfite;disodiumsulfite;exsiccatedsodiumsulfite;natriisulphis;natriumsulfid;natriumsulfit;natriumsulfurosum;sodiumsulfite(2:1) CAS: 7757-83-7 MF: Na2O3S MW: 126.04 EINECS: 231-821-4 Product Categories: Paper, glass, printing and dyeing;inorganic compound;Inorganic Chemicals;Inorganics;Analytical Reagents for General Use;Puriss p.a.;Essential Chemicals;Inorganic Salts;Synthetic Reagents;Disulfide Bridge Cleavage Reagents;AlphabeticalBiochemicals and Reagents;Biochemicals and Reagents;Denaturation;Q-S, Puriss p.a.;Water Ttreatment Chemicals;Reagent Grade;Routine Reagents;Disulfide Bridge Cleavage ReagentsSynthetic Reagents;ACS GradeBiochemicals and Reagents Mol File: 7757-83-7.mol   Sodium sulfite Chemical Properties Melting point  500 °C density  2.63 refractive index  1,484 storage temp.  Store at +5°C to +30°C. solubility  H2O: 1 M at 20 °C, clear, colorless form  Solid Specific Gravity 2.633 color  White to slightly yellow Odor Odorless PH Range 9.0 - 10.5 at 126 g/l at 25 °C PH 9.0-10.5 (25℃, 1M in H2O) Water Solubility  23 g/100 mL (20 ºC) Sensitive  Hygroscopic Merck  14,8682 Stability: Stable. Incompatible with strong acids. Moisture and air sensitive. CAS DataBase Reference 7757-83-7(CAS DataBase Reference) NIST Chemistry Reference sodium sulfite(7757-83-7) EPA Substance Registry System Sodium sulfite (7757-83-7)   Safety Information Hazard Codes  Xn Risk Statements  31-36/37/38-22-40-36/38 Safety Statements  24/25-36-26-22 WGK Germany  1 RTECS  WE2150000 F  3-10 TSCA  Yes HS Code  28321000 Hazardous Substances Data 7757-83-7(Hazardous Substances Data) Toxicity LD50 i.v. in mice: 175 mg/kg, Hoppe, Goble, J. Pharmacol. Exp. Ther. 101, 101 (1951) MSDS Information Provider Language Sodium sulfite English SigmaAldrich English ACROS English ALFA English   Sodium sulfite Usage And Synthesis Description As a soluble sodium salt of sulfurous acid, Sodium sulfite (Na2SO3) shows blenching, de-sulfurizing and dechlorinating properties which is widely applied in various fields. It is primarily used in the pulp and papermaking industry due to its blenching activity. It can serve as a good additive to help preserve the fresh appearance of good products. Besides, sodium sulfite is a component in many pharmaceuticals, which is effective to maintain the potency and stability of drugs. It can also be applied for water treatment as an oxygen scavenger agent and applied in flue gas desulfurization and preservation of photo developer solutions, etc. Uses Sodium sulfite (Na2SO3) is an antioxidant, used as a preservative except with meats. It is also used for water treatment and in photography and textile bleaching. References # # # # Chemical Properties Sodium sulfite occurs as an odorless white powder or hexagonal prisms. Note that the commercially available sodium sulfite is often presented as a white to tan- or pink-colored powder that would not conform to the pharmacopeial specification. Chemical Properties Sodium sulfite,Na2S03, is a white,water-soluble, crystalline solid with a sulfurous, salty taste. It decomposes when heated. Sodium sulfite is used as a source of sulfite,as a chemical intermediate and food preservative, in medicine and paper manufacturing, in photographic developing, and as a bleaching agent in the textile industry. Most boiler operators use sodium sulfite for chemicals cavenging of oxygen in the feedwater. Because it decomposes into acidic gases at the high temperatures that accompany high pressures, sodium sulfite should not be used for this purpose at pressures above 122atm (12.4MPa,or 1.8 ksi). Chemical Properties Sodium sulfite is a white crystalline solid Uses sodium sulfite has anti-septic, preservative, and anti-oxidant properties. Sodium sulfite is also a topical anti-fungal. Uses These white crystals were prepared by passing sulfurous gas over moist sodium carbonate. Sodium sulfite is soluble in water but less so in alcohol. It was used as a preservative for alkaline developers and as a hypo clearing agent in photographic printing. Uses Paper industry (semichemical pulp), reduc- ing agent (dyes), water treatment, photographic developer, food preservative and antioxidant, tex- tile bleaching (antichlor). Definition ChEBI: An inorganic sodium salt having sulfite as the counterion. Production Methods Sodium bisulfite is prepared by reacting sulfur dioxide gas with sodium hydroxide solution. The solid material is obtained by evaporation of water. Further neutralization with sodium hydroxide while keeping the temperature above 33.6°C leads to crystallization of the anhydrous sodium sulfite (below this temperature the heptahydrate form is obtained). Definition sodium sulphite: A white solid,Na2SO3, existing in an anhydrousform (r.d. 2.63) and as a heptahydrate(r.d. 1.59). Sodium sulphite is solublein water and because it is readily oxidizedit is widely used as a convenientreducing agent. It is preparedby reacting sulphur dioxide with eithersodium carbonate or sodium hydroxide.Dilute mineral acids reversethis process and release sulphur dioxide.Sodium sulphite is used as ableaching agent in textiles and inpaper manufacture. Its use as an antioxidantin some canned foodstuffsgives rise to a slightly sulphuroussmell immediately on opening, butits use is prohibited in meats or foodsthat contain vitamin B1. Sodium sulphitesolutions are occasionally usedas biological preservatives. General Description White odorless powder. Density 2.633 g / cm3. Moderately toxic. Sinks in water and dissolves slowly. Also transported as a heptahydrate Na2SO3.7H2O. Air & Water Reactions Soluble in water. Reacts with hot water, steam or acids to produce corrosive material. Reactivity Profile Sodium sulfite is a reducing agent, particularly under basic conditions. Reacts with oxidizing agents such as peroxides, epoxides, oxoacids. Emits toxic fumes of sodium oxide and oxides of sulfur if heated to decomposition [Lewis, 3rd ed., 1993, p. 1174]. Hazard Use prohibited in meats and other sources of Vitamin B 1 Health Hazard When ingested, solutions cause gastric irritation by the liberation of sulfurous acid. Because of rapid oxidation to sulfate, sulfites are well tolerated until large doses are reached; then violent colic and diarrhea, circulatory disturbances, central nervous depression, and death can occur. Fire Hazard Literature sources indicate that Sodium sulfite is noncombustible. Pharmaceutical Applications Sodium sulfite is used as an antioxidant in applications similar to those for sodium metabisulfite. It is also an effective antimicrobial preservative, particularly against fungi at low pH (0.1% w/v of sodium sulfite is used). Sodium sulfite is used in cosmetics, food products, and pharmaceutical applications such as parenteral formulations, inhalations, oral formulations, and topical preparations. Contact allergens Sodium sulfite is mainly used in photographic developers, for fixing prints, bleaching textile fibers, as a reducer in manufacturing dyes, as a remover of Cl in bleached textiles and paper, and as a preservative in the food industry for meat, egg yolks, and so on. Safety Profile Poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Na2O and SOx. A reducing agent. See also SULFITES. Safety Sodium sulfite is widely used in food and pharmaceutical applications as an antioxidant. It is generally regarded as relatively nontoxic and nonirritant when used as an excipient. However, contact dermatitis and hypersensitivity reactions have been reported. The acceptable daily intake for sodium sulfite has been set at up to 350 mg/kg body-weight daily. LD50 (mouse, IP): 0.950 g/kg LD50 (mouse, IV): 0.130 g/kg LD50 (mouse, oral): 0.820 g/kg LD50 (rabbit, IV): 0.065 g/kg LD50 (rabbit, oral): 1.181 g/kg LD50 (rat, IV): 0.115 g/kg Potential Exposure Sodium sulfite is used as a reducing agent; in boiler water treatment; food applications; in photographic developers and fixers; in bleaching of wool, paper, textiles, straw and silk; manufacture of dyes; dechlorination; preservation of meat, fruit and egg products; silvering of glass. Environmental Fate Because sodium sulfite is a solid powder that is generally sold as a ‘food grade’ substance, there is very little information available on the environmental fate of sodium sulfite. It has a molecular weight of 126.04 g mol-1. At 20°C, the solubility in water is 250 000 mg l-1, and as it is an inorganic salt the vapor is negligible (USEPA, 2011). The log octanol/water partition coefficient is estimated to be 7.78. If released into water or soil, sodium sulfite would most likely be oxidized to sulfate, which would then be available for use by bacteria or plants as a nutrient. The US Environmental Protection Agency (EPA) EPI Suite computer program (USEPA, 2011) estimates both a bioconcentration factor and a bioaccumulation factor of 0.89. These factors are less than one, meaning that bioconcentration and/or bioaccumulation of sodium sulfite would be virtually negligible and therefore would not cause any adverse effects to fish and wildlife. storage Sodium sulfite should be stored in a well-closed container in a cool, dry, place. In solution, sodium sulfite is slowly oxidized to sulfate by dissolved oxygen; strong acids lead to formation of sulfurous acid/ sulfur dioxide. On heating, sodium sulfite decomposes liberating sulfur oxides. Shipping UN3260 Corrosive solid, acidic, inorganic, n.o.s., Hazard class: 8; Labels: 8-Corrosive material. Purification Methods Crystallise the sulfite from warm water (0.5mL/g) by cooling to 0o. Also purify it by repeated crystallisation from deoxygenated water inside a glove-box, and finally drying it under vacuum. [Rhee & Dasgupta J Phys Chem 89 1799 1985.] Toxicity evaluation The exact mechanism of toxicity has not been elucidated, although there is a lot of information on how sulfur-based compounds are detoxified by the liver. Sodium sulfite is a mild reducing agent that would most likely cause burning or irritation at the site of exposure or application by altering oxidation–reduction potential and pH. Sulfites are used widely as antioxidants to keep foods from prematurely spoiling and to keep them looking ‘fresh’ by preventing oxidation and subsequent ‘browning.’ Many people, however, are ‘sulfite sensitive.’ After ingestion of food or beverages containing sulfite, these people may have allergictype reactions such as asthmatic wheezing, hypotension, tingling sensations, and flushing of the skin. The mechanism is unclear but probably has to do with an individual-specific chemical stimulation of the immune system, which in turn releases small amounts of vasoactive substances. Incompatibilities Sodium sulfite is incompatible with acids, oxidizing agents, many proteins, and vitamin B1. Incompatibilities A strong reducing agent. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases. Reacts with strong acids producing toxic sulfur dioxide. Regulatory Status GRAS listed. Accepted for use as a food additive in Europe. Included in FDA Inactive Ingredients Database (epidural, IM, IV, and SC injections; inhalation solution; ophthalmic solutions; oral syrups and suspensions; otic solutions; topical creams and emulsions). Included in nonparenteral medicines licensed in the UK.   Sodium sulfite Preparation Products And Raw materials Raw materials Sodium hydroxide-->Sulfuric acid-->Sodium carbonate-->Benzene-->Sulfur-->Phenol-->Sodium dithionite-->Sodium sulfide-->Sulfur dioxide-->Sulphur-->Sodium sulfide nonahydrate-->SODIUM SULFITE HEPTAHYDRATE Preparation Products 1,8-DINITROANTHRAQUINONE-->Sodium 1-hexanesulfonate-->(3-TRIFLUOROMETHOXY-PHENYL)-HYDRAZINE HYDROCHLORIDE-->1-HEPTANESULFONIC ACID SODIUM SALT MONOHYDRATE-->3,3-Dimethylglutaric acid-->6-FLUORO-2-NAPHTHOIC ACID-->2-(4-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE-->3-Cyanophenylhydrazine hydrochloride-->Sodium pentanesulfonate-->Sodium 1-octanesulfonate-->Sodium decane-1-sulfonate-->2-(2-FLUORO-PHENYL)-ETHANESULFONYL CHLORIDE-->1-HEXADECANESULFONIC ACID SODIUM SALT-->2-BROMORESORCINOL-->Sodium 1-heptanesulfonate-->1-TRIDECANESULFONIC ACID SODIUM SALT-->1-TETRADECANESULFONIC ACID SODIUM SALT-->Sodium 1-butanesulfonate-->2-Bromo-6-fluoronaphthalene-->1-NONANESULFONIC ACID SODIUM SALT-->1-BUTANESULFONIC ACID SODIUM SALT MONOHYDRATE-->4-TRIFLUOROMETHYLBENZYLSULFONYL CHLORIDE-->1-Methyl-4-(methylsulfonyl)-benzene-->R-(-)-Apomorphine-->Sodium 2-bromoethanesulphonate-->friction reducer SAF-->acramoll W paste-->O-TOLYL-METHANESULFONYL CHLORIDE-->6-BROMONAPHTHALEN-2-AMINE-->M-TOLYL-METHANESULFONYL CHLORIDE-->2-Trifluoromethylbenzylsulfonyl chloride-->2-NITRO-ALPHA-TOLUENESULFONYL CHLORIDE-->(2-FLUORO-PHENYL)-METHANESULFONYL CHLORIDE-->Zonisamide-->N-(4-iodobenzoyl)-L-glutamic acid-->1,4-Butane sultone-->4-Iodoanisole-->2-METHYL-2-PROPENE-1-SULFONIC ACID SODIUM SALT-->HEPTALDEHYDE SODIUM BISULFITE-->Emulsifier OS