China Original Largest Manufacturer sales SULFAMETHOXYPYRIDAZINE CAS 80-35-3 CAS NO.80-35-3

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Sulfamethoxypyridazine Basic information Product Name: Sulfamethoxypyridazine Synonyms: Sulfametoxipiridazine;Sulfanilamide, N1-(6-methoxy-3-pyridazinyl)-;Sulfapyridazine;Sulfdurazin;Sulfozona;Sulphamethoxypyridazine;Sultirene;Surirene CAS: 80-35-3 MF: C11H12N4O3S MW: 280.3 EINECS: 201-272-5 Product Categories: pharmaceutical;MIDICEL;Amines;Intermediates;Pharmaceuticals;Sulfur & Selenium Compounds;Pyrazine Mol File: 80-35-3.mol   Sulfamethoxypyridazine Chemical Properties Melting point  182-183° Boiling point  564.9±60.0 °C(Predicted) density  1.3936 (rough estimate) refractive index  1.6200 (estimate) storage temp.  2-8°C solubility  DMSO (Slightly), Methanol (Slightly) form  Crystalline Powder pka 6.7(at 25℃) color  White to yellow Water Solubility  579.5mg/L(25 ºC) Merck  14,8919 BRN  277076 CAS DataBase Reference 80-35-3(CAS DataBase Reference) NIST Chemistry Reference Pyridazine, sulfamethoxy-(80-35-3)   Safety Information Hazard Codes  Xi Risk Statements  37/38-41 Safety Statements  26-39 WGK Germany  2 RTECS  WP0400000 F  10 HS Code  29350090 Toxicity LD50 orally in mice: 1750 mg/kg, (Seki) MSDS Information Provider Language 4-Amino-N-(6-methoxy-3-pyridazinyl)-benzenesulfonamide English SigmaAldrich English   Sulfamethoxypyridazine Usage And Synthesis Chemical Properties White solid Uses Antibacterial. Uses Sulfamethoxypyridazine may be used as a reference standard for the determination of sulfamethoxypyridazine in pharmaceutical formulations by liquid chromatography method. Indications This drug possesses antibacterial activity with respect to a few cocci and colon bacillus. It is a long-lasting drug. It is used for treating pneumonia, bronchitis, tonsillitis, purulent otitis and meningitis, purulent infections of the urinary tract, dysentery, and others. Synonyms of this drug are sulfapyridazine, sufalex, retasulfin, and many others. Definition ChEBI: A sulfonamide consisting of pyridazine having a methoxy substituent at the 6-position and a 4-aminobenzenesulfonamido group at the 3-position. Brand name Amidin;Aseptilex;Asey-sulfa;Bimalong;Biocorn;Bio-cron;Bio-pectodil;Davosin suspension;Deltavagin;Desulfon;Durasul jarabe;Elix;Ensulfa;Eusulfa;Exazole;Farinffnicol;Fercasulf;Hesse-sulfon;Ketiak;Kynex acetyl;Lentosulfa;Linder;Logisul jarabe;Longamid;Longisul;Metamit;Metazina;Metuzina;Minikel;Novosulfin;Pirasulfon;Ralenta;Rotardon;S.d.m.;Septotryl;Smop;Sulamin;Sulfa spirig;Sulfabon;Sulfadazina;Sulfadepot;Sulfadin;Sulfadurazin;Sulfaintensa;Sulfakeyn;Sulfametopyridazin;Sulfamizina;Sulfamyd;Sulfapyrazin;Sulfatar;Sulfocidan;Sulfonamid;Sulforetent;Sulfo-rit;Unisulfa dulcis;Uroplex;Velaten;Volocid;Vtg 44. World Health Organization (WHO) Sulfamethoxypyridazine, a sulfonamide anti-infective agent, was introduced in 1957 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Commercial manufacture of the drug has been discontinued by at least one major manufacturer but supplies can still be obtained on special request, particularly for patients with dermatitis herpetiformis in which condition it has been claimed to be beneficial. General Description Sulfamethoxypyridazine is a sulfonamide antibiotic mainly used to prevent infections as well as conditions such as coccidiosis, diarrhea and gastroenteritis. Pharmaceutical Applications 3-Sulfanilamido-6-methoxypyridazine. Properties are similar to those of sulfadimethoxine. A rapidly absorbed, long-acting compound (half-life 38 h) with a high degree of protein binding (96%). A 1 g oral dose achieves a peak plasma concentration of around 100 mg/L after 5 h. Its use has been largely discontinued because of frequent adverse effects, but there are reports of benefit in dermatitis herpetiformis. It has been used in combination with trimethoprim. Chemical Synthesis Sulfamethoxypyridazine, N1 -(6-methoxy-3-pyridazinyl)sulfanilamide (33.1.43), is synthesized by replacing the chlorine atom in 6-chloro-3-(4-aminobenzenesulfonilamido)pyridazine with a methoxy group in 33.1.42 using sodium methoxide. The initial 6-chloro-3-(4-aminobenzenesulfonylamido)-pyridazine (33.1.42) is in turn synthesized by reacting 4-aminobenzenesulfanilamide with easily accessible 3,6-dichloropyridazine.   Sulfamethoxypyridazine Preparation Products And Raw materials Raw materials 4'-(6-methoxypyridazin-3-ylsulphamoyl)acetanilide Preparation Products 3-AMINO-6-METHOXYPYRIDAZINE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Sulfamethoxypyridazine Basic information Product Name: Sulfamethoxypyridazine Synonyms: Sulfametoxipiridazine;Sulfanilamide, N1-(6-methoxy-3-pyridazinyl)-;Sulfapyridazine;Sulfdurazin;Sulfozona;Sulphamethoxypyridazine;Sultirene;Surirene CAS: 80-35-3 MF: C11H12N4O3S MW: 280.3 EINECS: 201-272-5 Product Categories: pharmaceutical;MIDICEL;Amines;Intermediates;Pharmaceuticals;Sulfur & Selenium Compounds;Pyrazine Mol File: 80-35-3.mol   Sulfamethoxypyridazine Chemical Properties Melting point  182-183° Boiling point  564.9±60.0 °C(Predicted) density  1.3936 (rough estimate) refractive index  1.6200 (estimate) storage temp.  2-8°C solubility  DMSO (Slightly), Methanol (Slightly) form  Crystalline Powder pka 6.7(at 25℃) color  White to yellow Water Solubility  579.5mg/L(25 ºC) Merck  14,8919 BRN  277076 CAS DataBase Reference 80-35-3(CAS DataBase Reference) NIST Chemistry Reference Pyridazine, sulfamethoxy-(80-35-3)   Safety Information Hazard Codes  Xi Risk Statements  37/38-41 Safety Statements  26-39 WGK Germany  2 RTECS  WP0400000 F  10 HS Code  29350090 Toxicity LD50 orally in mice: 1750 mg/kg, (Seki) MSDS Information Provider Language 4-Amino-N-(6-methoxy-3-pyridazinyl)-benzenesulfonamide English SigmaAldrich English   Sulfamethoxypyridazine Usage And Synthesis Chemical Properties White solid Uses Antibacterial. Uses Sulfamethoxypyridazine may be used as a reference standard for the determination of sulfamethoxypyridazine in pharmaceutical formulations by liquid chromatography method. Indications This drug possesses antibacterial activity with respect to a few cocci and colon bacillus. It is a long-lasting drug. It is used for treating pneumonia, bronchitis, tonsillitis, purulent otitis and meningitis, purulent infections of the urinary tract, dysentery, and others. Synonyms of this drug are sulfapyridazine, sufalex, retasulfin, and many others. Definition ChEBI: A sulfonamide consisting of pyridazine having a methoxy substituent at the 6-position and a 4-aminobenzenesulfonamido group at the 3-position. Brand name Amidin;Aseptilex;Asey-sulfa;Bimalong;Biocorn;Bio-cron;Bio-pectodil;Davosin suspension;Deltavagin;Desulfon;Durasul jarabe;Elix;Ensulfa;Eusulfa;Exazole;Farinffnicol;Fercasulf;Hesse-sulfon;Ketiak;Kynex acetyl;Lentosulfa;Linder;Logisul jarabe;Longamid;Longisul;Metamit;Metazina;Metuzina;Minikel;Novosulfin;Pirasulfon;Ralenta;Rotardon;S.d.m.;Septotryl;Smop;Sulamin;Sulfa spirig;Sulfabon;Sulfadazina;Sulfadepot;Sulfadin;Sulfadurazin;Sulfaintensa;Sulfakeyn;Sulfametopyridazin;Sulfamizina;Sulfamyd;Sulfapyrazin;Sulfatar;Sulfocidan;Sulfonamid;Sulforetent;Sulfo-rit;Unisulfa dulcis;Uroplex;Velaten;Volocid;Vtg 44. World Health Organization (WHO) Sulfamethoxypyridazine, a sulfonamide anti-infective agent, was introduced in 1957 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Commercial manufacture of the drug has been discontinued by at least one major manufacturer but supplies can still be obtained on special request, particularly for patients with dermatitis herpetiformis in which condition it has been claimed to be beneficial. General Description Sulfamethoxypyridazine is a sulfonamide antibiotic mainly used to prevent infections as well as conditions such as coccidiosis, diarrhea and gastroenteritis. Pharmaceutical Applications 3-Sulfanilamido-6-methoxypyridazine. Properties are similar to those of sulfadimethoxine. A rapidly absorbed, long-acting compound (half-life 38 h) with a high degree of protein binding (96%). A 1 g oral dose achieves a peak plasma concentration of around 100 mg/L after 5 h. Its use has been largely discontinued because of frequent adverse effects, but there are reports of benefit in dermatitis herpetiformis. It has been used in combination with trimethoprim. Chemical Synthesis Sulfamethoxypyridazine, N1 -(6-methoxy-3-pyridazinyl)sulfanilamide (33.1.43), is synthesized by replacing the chlorine atom in 6-chloro-3-(4-aminobenzenesulfonilamido)pyridazine with a methoxy group in 33.1.42 using sodium methoxide. The initial 6-chloro-3-(4-aminobenzenesulfonylamido)-pyridazine (33.1.42) is in turn synthesized by reacting 4-aminobenzenesulfanilamide with easily accessible 3,6-dichloropyridazine.   Sulfamethoxypyridazine Preparation Products And Raw materials Raw materials 4'-(6-methoxypyridazin-3-ylsulphamoyl)acetanilide Preparation Products 3-AMINO-6-METHOXYPYRIDAZINE