China Largest Factory Manufacturer sales Helicid/ HELICIDUM CAS 80154-34-3 CAS NO.80154-34-3

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Helicid Basic information Brief description Extraction and Separation Determination of content Product Name: Helicid Synonyms: HILICIDUM;HELICID;HELICIDE;HELICIDUM;HELICID 97+% BY HPLC;Gynostemma;HEARTLEAFHOUTTUYNIAP.E.;4-Formylphenylb-D-allopyranoside CAS: 80154-34-3 MF: C13H16O7 MW: 284.26 EINECS: 1592732-453-0 Product Categories: reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Plant extracts;chemical reagent;pharmaceutical intermediate;phytochemical;Miscellaneous Natural Products;Allose;Biochemistry;Glycosides;Sugars;Natural Plant Extract Mol File: 80154-34-3.mol   Helicid Chemical Properties Melting point  199-200°C alpha  -27 º (c=3.2, MeOH) Boiling point  559.9±50.0 °C(Predicted) density  1.510±0.06 g/cm3(Predicted) storage temp.  under inert gas (nitrogen or Argon) at 2-8°C form  Powder pka 12.72±0.70(Predicted) color  White to Off-white Water Solubility  Soluble in hot water. Slightly soluble in water, ethanol or carbinol. Insoluble in aether or chloroform. InChIKey OLZAGZCCJJBKNZ-VLJOUNFMSA-N CAS DataBase Reference 80154-34-3(CAS DataBase Reference)   Safety Information HS Code  29389090 MSDS Information   Helicid Usage And Synthesis Brief description Helicid is the active ingredient isolated from the fruit of proteaceae plant Helicia nilagirica, with its chemical structure being similar to gastrodin (hydroxymethyl benzene - O-β-D-glucopyranoside). Pharmacological and clinical studies have shown that helicid has similar effects on the central nervous system with gastrodin, but its sedative, euthanasia and analgesic effect is stronger than gastrodin. The efficacy on the treatment of neurosis efficacy is definite without rebound insomnia and drug dependence. Therefore, it has excellent clinical value. Its fruit tablets have been used in clinical. Extraction and Separation  Figure 1 the process of purification of helicid from the fruit of proteaceae plant Helicia nilagirica Determination of content HPLC method (1) Chromatographic conditions Column: YWCT-C18 (25cm × 2.6mm, 10μm) high pressure grouting method. Flowing phase: methanol-water (20:80); flow rate: 0.7 ml / min; column temperature: room temperature; UV detection wavelength: 270 nm; paper speed: 2.5 mm / min. (2) Reference solution preparation Precisely weigh control reference substance of helicid; prepare 1 mg/mL solution using 20% methanol. Precise weigh Bergenin; dissolve in 20% methanol; apply ultrasonic solubilization, dub bergenin into about 2mg / ml internal standard solution. (3) Preparation of sample solution Accurately weighed dried helicid powder of about 1g, and put it into 25ml volumetric flask; add 20 mL methanol for soak of 0.5 h; ultrasonic extraction 80min, cool, set volume into 25 mL with methanol; filter and filtrate will become the sample solution. (4) Determination Take helicid reference solution in 5ml volumetric flask, add bergenin internal standard solution of 1.5ml; diluted with 20% methanol to the mark, mix; take 5 mL sample solution, volatilize; add 1. 5mL the internal standard solution; dilute with 20% methanol to the mark, mix well. Take 5μl of both reference substance and sample solution, inject, determine according to the chromatographic conditions; calculate the content with peak area ratio. (5) Measurement results Use the above internal standard method to measure the content of helicid in Samples I and II, and the results were 0.963% and 0.928%. Its chemical structure is similar to Gastrodia; have a strong analgesic, sedation and euthanasia effect. It is used for the treatment of neurasthenia, neurasthenic syndrome, functional disorders, vascular headache and trigeminal neuralgia. It has remarkable effect on neurasthenic headache, dizziness and sleep disorders. Chemical Properties It appears as white needle-like crystals, mp.190 °C ~ 193 °C, [α] D20-100 ° ~ -108 ° (water). Uses It is used in the treatment of ischemic cardiovascular and cerebrovascular diseases. Also used in Chinese medicine in the treatment of headache and insomnia.   Helicid Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Helicid Basic information Brief description Extraction and Separation Determination of content Product Name: Helicid Synonyms: HILICIDUM;HELICID;HELICIDE;HELICIDUM;HELICID 97+% BY HPLC;Gynostemma;HEARTLEAFHOUTTUYNIAP.E.;4-Formylphenylb-D-allopyranoside CAS: 80154-34-3 MF: C13H16O7 MW: 284.26 EINECS: 1592732-453-0 Product Categories: reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Plant extracts;chemical reagent;pharmaceutical intermediate;phytochemical;Miscellaneous Natural Products;Allose;Biochemistry;Glycosides;Sugars;Natural Plant Extract Mol File: 80154-34-3.mol   Helicid Chemical Properties Melting point  199-200°C alpha  -27 º (c=3.2, MeOH) Boiling point  559.9±50.0 °C(Predicted) density  1.510±0.06 g/cm3(Predicted) storage temp.  under inert gas (nitrogen or Argon) at 2-8°C form  Powder pka 12.72±0.70(Predicted) color  White to Off-white Water Solubility  Soluble in hot water. Slightly soluble in water, ethanol or carbinol. Insoluble in aether or chloroform. InChIKey OLZAGZCCJJBKNZ-VLJOUNFMSA-N CAS DataBase Reference 80154-34-3(CAS DataBase Reference)   Safety Information HS Code  29389090 MSDS Information   Helicid Usage And Synthesis Brief description Helicid is the active ingredient isolated from the fruit of proteaceae plant Helicia nilagirica, with its chemical structure being similar to gastrodin (hydroxymethyl benzene - O-β-D-glucopyranoside). Pharmacological and clinical studies have shown that helicid has similar effects on the central nervous system with gastrodin, but its sedative, euthanasia and analgesic effect is stronger than gastrodin. The efficacy on the treatment of neurosis efficacy is definite without rebound insomnia and drug dependence. Therefore, it has excellent clinical value. Its fruit tablets have been used in clinical. Extraction and Separation  Figure 1 the process of purification of helicid from the fruit of proteaceae plant Helicia nilagirica Determination of content HPLC method (1) Chromatographic conditions Column: YWCT-C18 (25cm × 2.6mm, 10μm) high pressure grouting method. Flowing phase: methanol-water (20:80); flow rate: 0.7 ml / min; column temperature: room temperature; UV detection wavelength: 270 nm; paper speed: 2.5 mm / min. (2) Reference solution preparation Precisely weigh control reference substance of helicid; prepare 1 mg/mL solution using 20% methanol. Precise weigh Bergenin; dissolve in 20% methanol; apply ultrasonic solubilization, dub bergenin into about 2mg / ml internal standard solution. (3) Preparation of sample solution Accurately weighed dried helicid powder of about 1g, and put it into 25ml volumetric flask; add 20 mL methanol for soak of 0.5 h; ultrasonic extraction 80min, cool, set volume into 25 mL with methanol; filter and filtrate will become the sample solution. (4) Determination Take helicid reference solution in 5ml volumetric flask, add bergenin internal standard solution of 1.5ml; diluted with 20% methanol to the mark, mix; take 5 mL sample solution, volatilize; add 1. 5mL the internal standard solution; dilute with 20% methanol to the mark, mix well. Take 5μl of both reference substance and sample solution, inject, determine according to the chromatographic conditions; calculate the content with peak area ratio. (5) Measurement results Use the above internal standard method to measure the content of helicid in Samples I and II, and the results were 0.963% and 0.928%. Its chemical structure is similar to Gastrodia; have a strong analgesic, sedation and euthanasia effect. It is used for the treatment of neurasthenia, neurasthenic syndrome, functional disorders, vascular headache and trigeminal neuralgia. It has remarkable effect on neurasthenic headache, dizziness and sleep disorders. Chemical Properties It appears as white needle-like crystals, mp.190 °C ~ 193 °C, [α] D20-100 ° ~ -108 ° (water). Uses It is used in the treatment of ischemic cardiovascular and cerebrovascular diseases. Also used in Chinese medicine in the treatment of headache and insomnia.   Helicid Preparation Products And Raw materials