China Largest Manufacturer factory Supply D-Panthenol/Dexpanthenol CAS 81-13-0 CAS NO.81-13-0

                                PRODUCT DETAILS       

Dexpanthenol Basic information Description References Product Name: Dexpanthenol Synonyms: 4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-(theta)-butanamid;4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-d-(+)-butyramid;Alcopan-250;Bepanthen;Bepanthene;Bepantol;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)- CAS: 81-13-0 MF: C9H19NO4 MW: 205.25 EINECS: 201-327-3 Product Categories: Inhibitors;haircare cosmetics;Pharmaceutical Intermediates;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;ILOPAN;81-13-0 Mol File: 81-13-0.mol   Dexpanthenol Chemical Properties Melting point  64～69℃ alpha  30.5 º (c=5, H2O on anh. sub) Boiling point  118-120 °C (2.7 mmHg) density  1.20 g/mL at 20 °C (lit.) refractive index  1.495-1.502 Fp  118-120°C/0.02m storage temp.  2-8°C solubility  DMSO (Sparingly), Methanol (Slightly), Water (Sparingly) pka 13.03±0.20(Predicted) form  Viscous Liquid or Semi Solid color  Clear colorless to slightly yellow PH pH (100g/l,25℃) : 8.5～10.5 optical activity [α]20/D +30±1°, c = 5% in H2O Water Solubility  soluble Sensitive  Hygroscopic Merck  14,2947 BRN  1724947 InChIKey SNPLKNRPJHDVJA-ZETCQYMHSA-N CAS DataBase Reference 81-13-0(CAS DataBase Reference) NIST Chemistry Reference Dexpanthenol(81-13-0) EPA Substance Registry System (+)-Panthenol (81-13-0)   Safety Information Hazard Codes  Xn Risk Statements  36/37/38-48-41-37/38-20/21/22 Safety Statements  23-24/25-45-36/37/39-26-22 WGK Germany  1 RTECS  ES4316000 F  3-10 TSCA  Yes HS Code  29241990 Hazardous Substances Data 81-13-0(Hazardous Substances Data) Toxicity LD50 oral in mouse: 15gm/kg MSDS Information Provider Language (+)-Panthenol English SigmaAldrich English ACROS English ALFA English   Dexpanthenol Usage And Synthesis Description Dexpanthenol belongs to a derivative of pantothenic acid (vitamin B5). It can penetrate the skin and mucous membrane to be quickly oxidized to pantothenic acid. The later one is extremely hygroscopic and binds water effectively. Therefore, Dexpanthenol can be used as a moisturizer. It is added to pharmaceutical and cosmetic products to relieve itching and improve wound healing. In ointments, it can be used for the treatment of sunburns, mild burns, minor skin injuries and disorders. It is also immediately applied after major abdominal surgery to minimize the possibility of paralytic ileus. In addition, it can also be supplemented into the commercial shampoos and hair conditioners to lubricate the hair shaft and give the hair a shiny appearance. The exact mechanism of action of Dexpanthenol is still unclear, perhaps through its enhancing effect on acetylcholine.   References # # # Chemical Properties clear colorless to slightly yellow viscous liquid Originator Bepanthene,Roche,France,1951 Uses Dexpanthenol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques as well as partial least-squares multivariate calibration. Uses cholinergic Uses D-Panthenol is an analogue of pantothenic acid (P190300), a member of the B complex vitamins. D-Panthenol is the biologically active enantiomer of Panthenol. Uses immunosuppressant, mitoxantrone analogue less toxic on cardiac tissue antineoplastic Manufacturing Process 130 parts by weight of d(-)-α-hydroxy-β,β-dimethyl-gamma-butyric acid lactone are dissolved in 150 parts by volume of methyl alcohol. 75 parts by weight of 3-hydroxypropylamine are added, in one portion, to the solution and the mixture is well stirred. While the reaction sets in, the temperature of the mixture gradually rises by itself to about 50°C and then drops again after about two hours. To cause completion of the reaction, the mixture is allowed to stand at room temperature for 24 hours. The so obtained (d+)-α,γdihydroxy-β,β-dimethyl-butyric-acid-(3'-hydroxypropyl)-amide is freed from methyl alcohol in vacuo. It is a colorless, viscous oil, easily soluble in water. It boils under a pressure of 0.02 mm between 118° and 120°C. Brand name D-Panthenol 50 (BASF); Ilopan (Savage); Motilyn (Abbott). Therapeutic Function Gastrointestinal drug General Description Dexpanthenol is an alcohol analog of pantothenic acid and an important component of parenterals, local cosmetic preparations and multi-vitamins. It has as much biological activity as pantothenic acid and is found to be stable in aqueous solution. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Biochem/physiol Actions D-Panthenol is the alcohol analogue and biological precursor of D-pantothenic acid. These analogues are precursors in the biosynthesis of coenzyme A. D-Panthenol and D-Pantothenic acid are used in a variety of skin protection products. D-pantothenic acid may have a role in controlling keratinocyte proliferation and differentiation. D-Panthenol may be used for studies of skin protection emulsions from UV irradiation and as a humectant. Contact allergens Pan(to)thenol is the alcohol corresponding to pantothenic acid, of the vitamin B5 group. It is used as a food additive, and in skin and hair products as a conditioning agent. Contact dermatitis and urticaria have been reported. Safety Profile Moderately toxic by intravenous route. A skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also AMIDES. Veterinary Drugs and Treatments Dexpanthenol has been suggested for use in intestinal atony or distension, postoperative retention of flatus and feces, prophylaxis and treatment of paralytic ileus after abdominal surgery or traumatic injuries, equine colic (not due to mechanical obstruction) and any other condition when there is an impairment of smooth muscle function. Controlled studies are lacking with regard to proving the efficacy of the drug for any of these indications. Purification Methods Purify D-panthenol by distillation in vacuo. It is a slightly hygroscopic viscous oil and is soluble in H2O and organic solvents. It is hydrolysed by alkali and strong acid. [Rabin J Am Pharm Assoc (Sci Ed) 37 502 1948, Bonati & Pitré Farmaco Ed Scient 14 43 1959, Beilstein 4 IV 1652.]   Dexpanthenol Preparation Products And Raw materials Raw materials 3-Aminopropanol

                                                                         About US 

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

                                                                       Group profiles

Our Factories production lines

                                                   Our Factories R&D ability

                        Our Factories warehouse 

                                                       Product information

Dexpanthenol Basic information Description References Product Name: Dexpanthenol Synonyms: 4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-(theta)-butanamid;4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-d-(+)-butyramid;Alcopan-250;Bepanthen;Bepanthene;Bepantol;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-;Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)- CAS: 81-13-0 MF: C9H19NO4 MW: 205.25 EINECS: 201-327-3 Product Categories: Inhibitors;haircare cosmetics;Pharmaceutical Intermediates;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;ILOPAN;81-13-0 Mol File: 81-13-0.mol   Dexpanthenol Chemical Properties Melting point  64～69℃ alpha  30.5 º (c=5, H2O on anh. sub) Boiling point  118-120 °C (2.7 mmHg) density  1.20 g/mL at 20 °C (lit.) refractive index  1.495-1.502 Fp  118-120°C/0.02m storage temp.  2-8°C solubility  DMSO (Sparingly), Methanol (Slightly), Water (Sparingly) pka 13.03±0.20(Predicted) form  Viscous Liquid or Semi Solid color  Clear colorless to slightly yellow PH pH (100g/l,25℃) : 8.5～10.5 optical activity [α]20/D +30±1°, c = 5% in H2O Water Solubility  soluble Sensitive  Hygroscopic Merck  14,2947 BRN  1724947 InChIKey SNPLKNRPJHDVJA-ZETCQYMHSA-N CAS DataBase Reference 81-13-0(CAS DataBase Reference) NIST Chemistry Reference Dexpanthenol(81-13-0) EPA Substance Registry System (+)-Panthenol (81-13-0)   Safety Information Hazard Codes  Xn Risk Statements  36/37/38-48-41-37/38-20/21/22 Safety Statements  23-24/25-45-36/37/39-26-22 WGK Germany  1 RTECS  ES4316000 F  3-10 TSCA  Yes HS Code  29241990 Hazardous Substances Data 81-13-0(Hazardous Substances Data) Toxicity LD50 oral in mouse: 15gm/kg MSDS Information Provider Language (+)-Panthenol English SigmaAldrich English ACROS English ALFA English   Dexpanthenol Usage And Synthesis Description Dexpanthenol belongs to a derivative of pantothenic acid (vitamin B5). It can penetrate the skin and mucous membrane to be quickly oxidized to pantothenic acid. The later one is extremely hygroscopic and binds water effectively. Therefore, Dexpanthenol can be used as a moisturizer. It is added to pharmaceutical and cosmetic products to relieve itching and improve wound healing. In ointments, it can be used for the treatment of sunburns, mild burns, minor skin injuries and disorders. It is also immediately applied after major abdominal surgery to minimize the possibility of paralytic ileus. In addition, it can also be supplemented into the commercial shampoos and hair conditioners to lubricate the hair shaft and give the hair a shiny appearance. The exact mechanism of action of Dexpanthenol is still unclear, perhaps through its enhancing effect on acetylcholine.   References # # # Chemical Properties clear colorless to slightly yellow viscous liquid Originator Bepanthene,Roche,France,1951 Uses Dexpanthenol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques as well as partial least-squares multivariate calibration. Uses cholinergic Uses D-Panthenol is an analogue of pantothenic acid (P190300), a member of the B complex vitamins. D-Panthenol is the biologically active enantiomer of Panthenol. Uses immunosuppressant, mitoxantrone analogue less toxic on cardiac tissue antineoplastic Manufacturing Process 130 parts by weight of d(-)-α-hydroxy-β,β-dimethyl-gamma-butyric acid lactone are dissolved in 150 parts by volume of methyl alcohol. 75 parts by weight of 3-hydroxypropylamine are added, in one portion, to the solution and the mixture is well stirred. While the reaction sets in, the temperature of the mixture gradually rises by itself to about 50°C and then drops again after about two hours. To cause completion of the reaction, the mixture is allowed to stand at room temperature for 24 hours. The so obtained (d+)-α,γdihydroxy-β,β-dimethyl-butyric-acid-(3'-hydroxypropyl)-amide is freed from methyl alcohol in vacuo. It is a colorless, viscous oil, easily soluble in water. It boils under a pressure of 0.02 mm between 118° and 120°C. Brand name D-Panthenol 50 (BASF); Ilopan (Savage); Motilyn (Abbott). Therapeutic Function Gastrointestinal drug General Description Dexpanthenol is an alcohol analog of pantothenic acid and an important component of parenterals, local cosmetic preparations and multi-vitamins. It has as much biological activity as pantothenic acid and is found to be stable in aqueous solution. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Biochem/physiol Actions D-Panthenol is the alcohol analogue and biological precursor of D-pantothenic acid. These analogues are precursors in the biosynthesis of coenzyme A. D-Panthenol and D-Pantothenic acid are used in a variety of skin protection products. D-pantothenic acid may have a role in controlling keratinocyte proliferation and differentiation. D-Panthenol may be used for studies of skin protection emulsions from UV irradiation and as a humectant. Contact allergens Pan(to)thenol is the alcohol corresponding to pantothenic acid, of the vitamin B5 group. It is used as a food additive, and in skin and hair products as a conditioning agent. Contact dermatitis and urticaria have been reported. Safety Profile Moderately toxic by intravenous route. A skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also AMIDES. Veterinary Drugs and Treatments Dexpanthenol has been suggested for use in intestinal atony or distension, postoperative retention of flatus and feces, prophylaxis and treatment of paralytic ileus after abdominal surgery or traumatic injuries, equine colic (not due to mechanical obstruction) and any other condition when there is an impairment of smooth muscle function. Controlled studies are lacking with regard to proving the efficacy of the drug for any of these indications. Purification Methods Purify D-panthenol by distillation in vacuo. It is a slightly hygroscopic viscous oil and is soluble in H2O and organic solvents. It is hydrolysed by alkali and strong acid. [Rabin J Am Pharm Assoc (Sci Ed) 37 502 1948, Bonati & Pitré Farmaco Ed Scient 14 43 1959, Beilstein 4 IV 1652.]   Dexpanthenol Preparation Products And Raw materials Raw materials 3-Aminopropanol