China Largest Manufacturer factory sales Calcium citrate CAS 813-94-5 CAS NO.813-94-5

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Calcium citrate Basic information Description References Product Name: Calcium citrate Synonyms: 1,2,3-Propanetricarboxylicacid,2-hydroxy-,calciumsalt(2:3);2,3-propanetricarboxylicacid,2-hydroxy-calciumsalt(2:3);acicontral;citricacid,calciumsalt(2:3);Calsium citrate;supply good quality calcium citrate;citrical;tribasiccalciumcitrate CAS: 813-94-5 MF: C12H10Ca3O14 MW: 498.43 EINECS: 212-391-7 Product Categories: Food additive and acidulant Mol File: 813-94-5.mol   Calcium citrate Chemical Properties solubility  0.1 M HCl: 0.01 M at 20 °C, clear, colorless Stability: Stable. Incompatible with strong oxidizing agents. CAS DataBase Reference 813-94-5(CAS DataBase Reference) EPA Substance Registry System Tricalcium citrate (813-94-5)   Safety Information WGK Germany  1 Hazardous Substances Data 813-94-5(Hazardous Substances Data) MSDS Information   Calcium citrate Usage And Synthesis Description Calcium citrate, a naturally occurring chemical in most plants and animals, is the calcium salt derived from citric acid. Calcium citrate is present in foods which have naturally occurring citric acid. Calcium citrate is used as a calcium supplement and may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). Calcium citrate may be chemopreventive for colon and other cancers. Calcium citrate is used as an ingredient in dietary supplements, and as a nutrient, sequestrant, buffer, antioxidant, firming agent, acidity regulator (in jams and jellies, soft drinks and wines), as a raising agent and an emulsifying salt. It is also used to improve the baking properties of flours and as a stabilizer. References # # # # # Description Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also used as a water softener because the citrate ions can chelate unwanted metal ions. Calcium citrate is also found in some dietary calcium supplements (e.g. Citracal). Calcium makes up 21% of calcium citrate by weight. Chemical Properties white powder or white to colourless crystals Production Methods Calcium citrate is an intermediate in the isolation of citric acid from the fermentation process by which citric acid is produced industrially. The citric acid in the broth solution is neutralized by calcium hydroxide, precipitating insoluble calcium citrate. This is then filtered off from the rest of the broth and washed to give clean calcium citrate. The calcium citrate thus produced may be sold as-is, or it may be converted to citric acid using dilute sulfuric acid. Pharmaceutical Applications Calcium citrate is more easily absorbed (bioavailability is 2.5 times higher than calcium carbonate); it is easier to digest and less likely to cause constipation and gas than calcium carbonate. Calcium citrate can be taken without food and is more easily absorbed than calcium carbonate on an empty stomach. It is also believed that it contributes less to the formation of kidney stones. Calcium citrate consists of around 24% Ca2+, which means that 1000 mg calcium citrate contains around 240 mg Ca2+. The lower Ca2+ content together with the higher price makes it a more expensive treatment option compared to calcium carbonate, but its slightly different application field can justify this. Biological Activity In many individuals, bioavailability of calcium citrate is found to be equal to that of the cheaper calcium carbonate.However, alterations to the digestive tract may change how calcium is digested and absorbed. Unlike calcium carbonate, which is basic and neutralizes stomach acid, calcium citrate has no effect on stomach acid. Individuals who are sensitive to antacids or who have difficulty producing adequate stomach acid should choose calcium citrate over calcium carbonate for supplementation. According to recent research into calcium absorption after gastric bypass surgery , calcium citrate may have improved bioavailability over calcium carbonate in Rouxen- Y gastric bypass patients who are taking calcium citrate as a dietary supplement after surgery. This is mainly due to the changes related to where calcium absorption occurs in the digestive tract of these individuals.   Calcium citrate Preparation Products And Raw materials Raw materials Calcium carbonate-->Citric acid-->Calcium chloride hexahydrate-->Citric acid monohydrate

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Calcium citrate Basic information Description References Product Name: Calcium citrate Synonyms: 1,2,3-Propanetricarboxylicacid,2-hydroxy-,calciumsalt(2:3);2,3-propanetricarboxylicacid,2-hydroxy-calciumsalt(2:3);acicontral;citricacid,calciumsalt(2:3);Calsium citrate;supply good quality calcium citrate;citrical;tribasiccalciumcitrate CAS: 813-94-5 MF: C12H10Ca3O14 MW: 498.43 EINECS: 212-391-7 Product Categories: Food additive and acidulant Mol File: 813-94-5.mol   Calcium citrate Chemical Properties solubility  0.1 M HCl: 0.01 M at 20 °C, clear, colorless Stability: Stable. Incompatible with strong oxidizing agents. CAS DataBase Reference 813-94-5(CAS DataBase Reference) EPA Substance Registry System Tricalcium citrate (813-94-5)   Safety Information WGK Germany  1 Hazardous Substances Data 813-94-5(Hazardous Substances Data) MSDS Information   Calcium citrate Usage And Synthesis Description Calcium citrate, a naturally occurring chemical in most plants and animals, is the calcium salt derived from citric acid. Calcium citrate is present in foods which have naturally occurring citric acid. Calcium citrate is used as a calcium supplement and may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). Calcium citrate may be chemopreventive for colon and other cancers. Calcium citrate is used as an ingredient in dietary supplements, and as a nutrient, sequestrant, buffer, antioxidant, firming agent, acidity regulator (in jams and jellies, soft drinks and wines), as a raising agent and an emulsifying salt. It is also used to improve the baking properties of flours and as a stabilizer. References # # # # # Description Calcium citrate is the calcium salt of citric acid. It is commonly used as a food additive (E333), usually as a preservative, but sometimes for flavor. In this sense, it is similar to sodium citrate. Calcium citrate is also used as a water softener because the citrate ions can chelate unwanted metal ions. Calcium citrate is also found in some dietary calcium supplements (e.g. Citracal). Calcium makes up 21% of calcium citrate by weight. Chemical Properties white powder or white to colourless crystals Production Methods Calcium citrate is an intermediate in the isolation of citric acid from the fermentation process by which citric acid is produced industrially. The citric acid in the broth solution is neutralized by calcium hydroxide, precipitating insoluble calcium citrate. This is then filtered off from the rest of the broth and washed to give clean calcium citrate. The calcium citrate thus produced may be sold as-is, or it may be converted to citric acid using dilute sulfuric acid. Pharmaceutical Applications Calcium citrate is more easily absorbed (bioavailability is 2.5 times higher than calcium carbonate); it is easier to digest and less likely to cause constipation and gas than calcium carbonate. Calcium citrate can be taken without food and is more easily absorbed than calcium carbonate on an empty stomach. It is also believed that it contributes less to the formation of kidney stones. Calcium citrate consists of around 24% Ca2+, which means that 1000 mg calcium citrate contains around 240 mg Ca2+. The lower Ca2+ content together with the higher price makes it a more expensive treatment option compared to calcium carbonate, but its slightly different application field can justify this. Biological Activity In many individuals, bioavailability of calcium citrate is found to be equal to that of the cheaper calcium carbonate.However, alterations to the digestive tract may change how calcium is digested and absorbed. Unlike calcium carbonate, which is basic and neutralizes stomach acid, calcium citrate has no effect on stomach acid. Individuals who are sensitive to antacids or who have difficulty producing adequate stomach acid should choose calcium citrate over calcium carbonate for supplementation. According to recent research into calcium absorption after gastric bypass surgery , calcium citrate may have improved bioavailability over calcium carbonate in Rouxen- Y gastric bypass patients who are taking calcium citrate as a dietary supplement after surgery. This is mainly due to the changes related to where calcium absorption occurs in the digestive tract of these individuals.   Calcium citrate Preparation Products And Raw materials Raw materials Calcium carbonate-->Citric acid-->Calcium chloride hexahydrate-->Citric acid monohydrate