China Largest Factory Manufacturer sales 1-Adamantane Carboxylic Acid CAS 828-51-3 CAS NO.828-51-3

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1-Adamantanecarboxylic acid Basic information Product Name: 1-Adamantanecarboxylic acid Synonyms: 1-Adamantanecarboxylic;Adamantane-1-carboxylic acid 99%;1-ADMANTANE CARBOXYLIC ACID;1-Adamantane-1-carboxylic acid;1-Adamantanecarboxylic acid ,99%;3-adamantanecarboxylicacid;adamantanecarboxylic acid;Adamantoic acid CAS: 828-51-3 MF: C11H16O2 MW: 180.24 EINECS: 212-584-6 Product Categories: C11 to C12;Carbonyl Compounds;Organic acids;Adamantanes;Carboxylic Acids Mol File: 828-51-3.mol   1-Adamantanecarboxylic acid Chemical Properties Melting point  172-174 °C (lit.) Boiling point  253.08°C (rough estimate) density  0.9976 (rough estimate) refractive index  1.4910 (estimate) storage temp.  Sealed in dry,Room Temperature solubility  Chloroform, Methanol (Slightly) pka 4.86±0.20(Predicted) form  Crystalline Powder color  White to off-white Water Solubility  Insoluble in water. Solubility in methanol gives very faint turbidity. Soluble in ethanol, chloroform, and dichloromethane. BRN  1910637 InChIKey JIMXXGFJRDUSRO-UHFFFAOYSA-N CAS DataBase Reference 828-51-3(CAS DataBase Reference) NIST Chemistry Reference Adamantane-1-carboxylic acid(828-51-3)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  22-24/25-36-26 WGK Germany  3 RTECS  AU4452200 Hazard Note  Irritant HS Code  29162000 MSDS Information Provider Language Tricyclo[3.3.1.1(3,7)]decan-1-Carboxylic acid English SigmaAldrich English ACROS English ALFA English   1-Adamantanecarboxylic acid Usage And Synthesis Chemical Properties white to off-white crystalline powder Uses Adamantoic Acid is an inhibitor of chorismate mutase activity and hydroxyphenylpyruvate synthase. It inhibits TTR conformational changes facilitating amyloid fibril formation. Uses It can be used as a stabilizer in the synthesis of monodisperse, highly crystalline CoPt3 nanoparticles1 and porous platinum nanoparticles. It is a potent and reversible CerK inhibitor. Uses 1-Adamantanecarboxylic acid can be used as: A stabilizer in the synthesis of monodisperse, highly crystalline CoPt3 nanoparticles and porous platinum nanoparticles. An additive in polycondensation reactions to yield conjugated polymers as possible optoelectronic materials. An additive in the allylic substitution reaction, which is catalyzed by palladium in an aqueous medium. Synthesis Reference(s) Synthetic Communications, 18, p. 545, 1988 DOI: 10.1080/00397918808060749 Biochem/physiol Actions 1-Adamantanecarboxylic acid undergoes complexation reactions with cyclohexaamylose. It is an inhibitor of phenyl ester hydrolysis of cycloheptaamylose. Purification Methods Possible impurities are trimethylacetic acid and C9 and C13 acids. Dissolve 15g of the acid in CCl4 (300mL) and shake with 110mL of 15N aqueous NH3 whereby the ammonium salt separates and is collected. Acid impurities form soluble ammonium salts. The salt is washed with cold Me2CO (20mL) and suspended in H2O (250mL). This is treated with 12N HCl and extracted with CHCl3 (100mL). The dried (Na2SO4) extract was evaporated and the residue was recrystallised from a mixture of MeOH (30mL) and H2O (ca 10mL) to give the pure acid (10-11g). [Koch & Haaf Org Synth Coll Vol V 20 1973.] It was also recrystallised from absolute EtOH and dried under vacuum at 100o. Alternatively, the acid (5g) is refluxed for 2hours with 15mL of MeOH and 2mL of 98% H2SO4 (cool when mixing this solution). Pour into 10 volumes of H2O and extract with the minimum volume of CHCl3 to give clear separation of phases. The extract is washed with H2O, dried (CaCl2) and distilled. The methyl ester is collected at 77-79o/1mm, m 38-39o. The ester is hydrolysed with the calculated amount of N KOH and refluxed until clear. Acidification with HCl provides the pure acid with 90% recovery. The amide crystallises from cyclohexane, m 189o. [Stetter et al. Chem Ber 92 1629 1959.] [Beilstein 9 IV 253.]   1-Adamantanecarboxylic acid Preparation Products And Raw materials Preparation Products 1-Adamantanemethylamine-->1-Adamantanecarbonyl chloride-->2-(1-Adamantyl)oxirane-->1-FLUOROADAMANTANE-->1,3,5,7-ADAMANTANETETRACARBOXYLIC ACID-->1-METHYLADAMANTANE-->Ethyl adamantane-1-carboxylate-->1-ADAMANTANECARBOXAMIDE-->1-Chloroadamantane-->ADAMANTANE-1-CARBOXYLIC ACID METHYL ESTER

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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1-Adamantanecarboxylic acid Basic information Product Name: 1-Adamantanecarboxylic acid Synonyms: 1-Adamantanecarboxylic;Adamantane-1-carboxylic acid 99%;1-ADMANTANE CARBOXYLIC ACID;1-Adamantane-1-carboxylic acid;1-Adamantanecarboxylic acid ,99%;3-adamantanecarboxylicacid;adamantanecarboxylic acid;Adamantoic acid CAS: 828-51-3 MF: C11H16O2 MW: 180.24 EINECS: 212-584-6 Product Categories: C11 to C12;Carbonyl Compounds;Organic acids;Adamantanes;Carboxylic Acids Mol File: 828-51-3.mol   1-Adamantanecarboxylic acid Chemical Properties Melting point  172-174 °C (lit.) Boiling point  253.08°C (rough estimate) density  0.9976 (rough estimate) refractive index  1.4910 (estimate) storage temp.  Sealed in dry,Room Temperature solubility  Chloroform, Methanol (Slightly) pka 4.86±0.20(Predicted) form  Crystalline Powder color  White to off-white Water Solubility  Insoluble in water. Solubility in methanol gives very faint turbidity. Soluble in ethanol, chloroform, and dichloromethane. BRN  1910637 InChIKey JIMXXGFJRDUSRO-UHFFFAOYSA-N CAS DataBase Reference 828-51-3(CAS DataBase Reference) NIST Chemistry Reference Adamantane-1-carboxylic acid(828-51-3)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  22-24/25-36-26 WGK Germany  3 RTECS  AU4452200 Hazard Note  Irritant HS Code  29162000 MSDS Information Provider Language Tricyclo[3.3.1.1(3,7)]decan-1-Carboxylic acid English SigmaAldrich English ACROS English ALFA English   1-Adamantanecarboxylic acid Usage And Synthesis Chemical Properties white to off-white crystalline powder Uses Adamantoic Acid is an inhibitor of chorismate mutase activity and hydroxyphenylpyruvate synthase. It inhibits TTR conformational changes facilitating amyloid fibril formation. Uses It can be used as a stabilizer in the synthesis of monodisperse, highly crystalline CoPt3 nanoparticles1 and porous platinum nanoparticles. It is a potent and reversible CerK inhibitor. Uses 1-Adamantanecarboxylic acid can be used as: A stabilizer in the synthesis of monodisperse, highly crystalline CoPt3 nanoparticles and porous platinum nanoparticles. An additive in polycondensation reactions to yield conjugated polymers as possible optoelectronic materials. An additive in the allylic substitution reaction, which is catalyzed by palladium in an aqueous medium. Synthesis Reference(s) Synthetic Communications, 18, p. 545, 1988 DOI: 10.1080/00397918808060749 Biochem/physiol Actions 1-Adamantanecarboxylic acid undergoes complexation reactions with cyclohexaamylose. It is an inhibitor of phenyl ester hydrolysis of cycloheptaamylose. Purification Methods Possible impurities are trimethylacetic acid and C9 and C13 acids. Dissolve 15g of the acid in CCl4 (300mL) and shake with 110mL of 15N aqueous NH3 whereby the ammonium salt separates and is collected. Acid impurities form soluble ammonium salts. The salt is washed with cold Me2CO (20mL) and suspended in H2O (250mL). This is treated with 12N HCl and extracted with CHCl3 (100mL). The dried (Na2SO4) extract was evaporated and the residue was recrystallised from a mixture of MeOH (30mL) and H2O (ca 10mL) to give the pure acid (10-11g). [Koch & Haaf Org Synth Coll Vol V 20 1973.] It was also recrystallised from absolute EtOH and dried under vacuum at 100o. Alternatively, the acid (5g) is refluxed for 2hours with 15mL of MeOH and 2mL of 98% H2SO4 (cool when mixing this solution). Pour into 10 volumes of H2O and extract with the minimum volume of CHCl3 to give clear separation of phases. The extract is washed with H2O, dried (CaCl2) and distilled. The methyl ester is collected at 77-79o/1mm, m 38-39o. The ester is hydrolysed with the calculated amount of N KOH and refluxed until clear. Acidification with HCl provides the pure acid with 90% recovery. The amide crystallises from cyclohexane, m 189o. [Stetter et al. Chem Ber 92 1629 1959.] [Beilstein 9 IV 253.]   1-Adamantanecarboxylic acid Preparation Products And Raw materials Preparation Products 1-Adamantanemethylamine-->1-Adamantanecarbonyl chloride-->2-(1-Adamantyl)oxirane-->1-FLUOROADAMANTANE-->1,3,5,7-ADAMANTANETETRACARBOXYLIC ACID-->1-METHYLADAMANTANE-->Ethyl adamantane-1-carboxylate-->1-ADAMANTANECARBOXAMIDE-->1-Chloroadamantane-->ADAMANTANE-1-CARBOXYLIC ACID METHYL ESTER