The world Biggest Manufacturer factory sales 2-Hydroxy-1,4-naphoquinone CAS 83-72-7 CAS NO.83-72-7

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2-Hydroxy-1,4-naphoquinone Basic information Description Chemical Propterties Application Biological Toxicity Product Name: 2-Hydroxy-1,4-naphoquinone Synonyms: 1,4-Naphthalenedione,2-hydroxy-;1,4-Naphthoquinone, 2-hydroxy-;2-Hydroxy-1,4-naphthalenedione;2-hydroxy-4-naphthalenedione;2-hydroxy-4-naphthoquinone;2-Hydroxynaphthoquinone;Lawsone, Natural Orange 6;1,4-Dihydro-1,4-dioxo-2-hydroxynaphthalene CAS: 83-72-7 MF: C10H6O3 MW: 174.15 EINECS: 201-496-3 Product Categories: Pyridines;Inhibitors;Intermediates of Dyes and Pigments;Anthraquinones, Hydroquinones and Quinones Mol File: 83-72-7.mol   2-Hydroxy-1,4-naphoquinone Chemical Properties Melting point  192-195 °C (dec.)(lit.) Boiling point  265.11°C (rough estimate) density  1.2346 (rough estimate) refractive index  1.5036 (estimate) storage temp.  Sealed in dry,Room Temperature solubility  Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly) pka 4.31±0.10(Predicted) form  Crystalline Powder Colour Index  75480 color  Yellow Water Solubility  2 g/L (20 ºC) Merck  14,5393 BRN  1565260 Stability: Stable. Combustible. Incompatible with strong oxidizing agents. InChIKey CSFWPUWCSPOLJW-UHFFFAOYSA-N CAS DataBase Reference 83-72-7(CAS DataBase Reference) NIST Chemistry Reference 1,4-Naphthalenedione, 2-hydroxy-(83-72-7) EPA Substance Registry System 2-Hydroxy-1,4-naphthoquinone (83-72-7)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36/37/38-68-36-22 Safety Statements  26-37/39-36/37/39-36 WGK Germany  3 RTECS  QL8200000 TSCA  Yes HS Code  29146990 MSDS Information Provider Language 2-Hydroxy-1,4-naphoquinone English ACROS English SigmaAldrich English ALFA English   2-Hydroxy-1,4-naphoquinone Usage And Synthesis Description Lawsone [CAS: 83-72-7] (CI Natural Orange 6; CI 75420), also known as henna and isojuglone, occurs in the shrub henna (Lawsone alba). In England, the plant is known as Egyptian privet. The dye was extracted from the leaves of the plant, using sodium bicarbonate, and the extracts used to dye protein fibers an orange shade. Henna is probably the oldest cosmetic known. The ancient Egyptians used it as a hair dye and for staining fingernails. It is said that Mohammed dyed his beard with henna. Lawsone has been identified as 2-hydroxy-1,4-naphthoquinone. It has been synthesized by the Thiele acetylation of 1,4-naphthoquinone followed by hydrolysis and oxidation. Chemical Propterties 2-Hydroxy-1,4-naphthoquinone (HNQ, C10H6O3) is also called Lawsone, which is a white cubic crystal. Its melting point is 192-195 oC, and flash point is 192 oC. The solubility of HNQ is 2 g/L in water at 20 oC. It is stable, but it is combustible and incompatible with strong oxidizing agents. Application 2-Hydroxy-1,4-naphthoquinone(HNQ) is the principal natural dye ingredient contained at 1.0-1.4% in the leaves of Henna (Lawsonia inermis). It is an ancient red-orange dye. Henna has been used for more than 4000 years not only as a hair dye, but also as a body paint and tattoo dye. Today, semi-permanent hair dyes containing Henna as well as its pure dye ingredient HNQ are widely used and have become increasingly popular due to their natural origin. Biological Toxicity 2-Hydroxy-1,4-naphoquinone(HNQ) was reported to be a weak bacterial mutagen for Salmonella typhimurium strain TA98 or was more clearly mutagenic for strain TA 2637, both in the presence of metabolic activation. HNQ was unable to induce sex-linked recessive lethal mutations in Drosophila melanogaster. The available data suggest that the use of Henna or 2-Hydroxy-1,4-naphoquinone(HNQ) for hair dyeing presents no or negligible risk of genotoxicity to the consumer. Chemical Properties Yellow crystal powder History Lawsone (CI Natural Orange 6; CI 75420), also known as henna and isojuglone, occurs in the shrub henna (Lawsone alba). In England, the plant is known as Egyptian privet. The dye was extracted from the leaves of the plant, using sodium bicarbonate, and the extracts used to dye protein fibers an orange shade. Henna is probably the oldest cosmetic known. The ancient Egyptians used it as a hair dye and for staining fingernails. It is said that Mohammed dyed his beard with henna. Lawsone has been identified as 2-hydroxy-1,4-naphthoquinone. It has been synthesized by the Thiele acetylation of 1,4-naphthoquinone followed by hydrolysis and oxidation. Uses 2-Hydroxy-1,4-naphthoquinone is used for preparing decorative hair and skin dyes. 2-Hydroxy-1,4-naphthoquinone also demonstrates antimicrobial and antioxidant effects. It also suppress the formation of hydrogen peroxide and superoxide radical anion by aldehyde oxidase-catalyzed reactions. Uses antifungal, sunscreen, antibacterial, antineoplastic Uses An antimicrobial antioxidant dye isolated from Henna. Definition A coloring principle obtained from dried leaves of certain tropical plants (North Africa, India). Synthesis Reference(s) The Journal of Organic Chemistry, 53, p. 808, 1988 DOI: 10.1021/jo00239a023 Tetrahedron Letters, 25, p. 533, 1984 DOI: 10.1016/S0040-4039(00)99930-1 General Description Yellow prisms or yellow powder. Air & Water Reactions Insoluble in water. Reactivity Profile Phenols, such as 2-Hydroxy-1,4-naphoquinone, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. Health Hazard ACUTE/CHRONIC HAZARDS: 2-Hydroxy-1,4-naphoquinone may be absorbed through the skin and can cause skin irritation. Fire Hazard Flash point data for 2-Hydroxy-1,4-naphoquinone are not available but 2-Hydroxy-1,4-naphoquinone is probably combustible. Contact allergens Henna, prepared by powdering the dried leaves of henna plant (Lawsonia inermis L.), is used for coloring and conditioning hair and nails, particularly by Muslims or Hindus. It contains Lawsone, which very rarely induces contact allergy. Most dermatitis caused by “black henna” is due to PPD and derivatives Purification Methods Crystallise Lawsone B from *C6H6 or AcOH (m 192.5o, 195-196o). It sublimes in a vacuum (m 194o). It has UV with max at 455nm (aqueous NaOH). [Beilstein 8 H 300, 8 I 635, 8 II 344, 8 III 2543, 8 IV 2360.]   2-Hydroxy-1,4-naphoquinone Preparation Products And Raw materials Raw materials Ammonium sulfamate-->1,4-Naphthoquinone-->1,2-NAPHTHOQUINONE-->naphthalene-1,2,4-triyl triacetate-->naphthalene-1,2,4-triol-->2-Naphthalenol, 1,4-dimethoxy--->1,3-DIHYDROXYNAPHTHALENE-->2-METHOXY-1,4-NAPHTHOQUINONE-->4-methoxynaphthalene-1,2-dione-->1,2-DIHYDROXYNAPHTHALENE-->2-Chloro-3-hydroxy-1,4-naphthoquinone-->2-hydroxy-3-iodonaphthalene-1,4-dione-->1,4-Dihydroxynaphthalene-->2-Naphthol-->1-Tetralone-->2-Methoxynaphthalene-->2-NITROTHIOPHENOL Preparation Products NILE RED-->2-Chloro-1,4-naphthoquinone Tag:2-Hydroxy-1,4-naphoquinone(83-72-7) Related Product Information

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2-Hydroxy-1,4-naphoquinone Basic information Description Chemical Propterties Application Biological Toxicity Product Name: 2-Hydroxy-1,4-naphoquinone Synonyms: 1,4-Naphthalenedione,2-hydroxy-;1,4-Naphthoquinone, 2-hydroxy-;2-Hydroxy-1,4-naphthalenedione;2-hydroxy-4-naphthalenedione;2-hydroxy-4-naphthoquinone;2-Hydroxynaphthoquinone;Lawsone, Natural Orange 6;1,4-Dihydro-1,4-dioxo-2-hydroxynaphthalene CAS: 83-72-7 MF: C10H6O3 MW: 174.15 EINECS: 201-496-3 Product Categories: Pyridines;Inhibitors;Intermediates of Dyes and Pigments;Anthraquinones, Hydroquinones and Quinones Mol File: 83-72-7.mol   2-Hydroxy-1,4-naphoquinone Chemical Properties Melting point  192-195 °C (dec.)(lit.) Boiling point  265.11°C (rough estimate) density  1.2346 (rough estimate) refractive index  1.5036 (estimate) storage temp.  Sealed in dry,Room Temperature solubility  Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly) pka 4.31±0.10(Predicted) form  Crystalline Powder Colour Index  75480 color  Yellow Water Solubility  2 g/L (20 ºC) Merck  14,5393 BRN  1565260 Stability: Stable. Combustible. Incompatible with strong oxidizing agents. InChIKey CSFWPUWCSPOLJW-UHFFFAOYSA-N CAS DataBase Reference 83-72-7(CAS DataBase Reference) NIST Chemistry Reference 1,4-Naphthalenedione, 2-hydroxy-(83-72-7) EPA Substance Registry System 2-Hydroxy-1,4-naphthoquinone (83-72-7)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36/37/38-68-36-22 Safety Statements  26-37/39-36/37/39-36 WGK Germany  3 RTECS  QL8200000 TSCA  Yes HS Code  29146990 MSDS Information Provider Language 2-Hydroxy-1,4-naphoquinone English ACROS English SigmaAldrich English ALFA English   2-Hydroxy-1,4-naphoquinone Usage And Synthesis Description Lawsone [CAS: 83-72-7] (CI Natural Orange 6; CI 75420), also known as henna and isojuglone, occurs in the shrub henna (Lawsone alba). In England, the plant is known as Egyptian privet. The dye was extracted from the leaves of the plant, using sodium bicarbonate, and the extracts used to dye protein fibers an orange shade. Henna is probably the oldest cosmetic known. The ancient Egyptians used it as a hair dye and for staining fingernails. It is said that Mohammed dyed his beard with henna. Lawsone has been identified as 2-hydroxy-1,4-naphthoquinone. It has been synthesized by the Thiele acetylation of 1,4-naphthoquinone followed by hydrolysis and oxidation. Chemical Propterties 2-Hydroxy-1,4-naphthoquinone (HNQ, C10H6O3) is also called Lawsone, which is a white cubic crystal. Its melting point is 192-195 oC, and flash point is 192 oC. The solubility of HNQ is 2 g/L in water at 20 oC. It is stable, but it is combustible and incompatible with strong oxidizing agents. Application 2-Hydroxy-1,4-naphthoquinone(HNQ) is the principal natural dye ingredient contained at 1.0-1.4% in the leaves of Henna (Lawsonia inermis). It is an ancient red-orange dye. Henna has been used for more than 4000 years not only as a hair dye, but also as a body paint and tattoo dye. Today, semi-permanent hair dyes containing Henna as well as its pure dye ingredient HNQ are widely used and have become increasingly popular due to their natural origin. Biological Toxicity 2-Hydroxy-1,4-naphoquinone(HNQ) was reported to be a weak bacterial mutagen for Salmonella typhimurium strain TA98 or was more clearly mutagenic for strain TA 2637, both in the presence of metabolic activation. HNQ was unable to induce sex-linked recessive lethal mutations in Drosophila melanogaster. The available data suggest that the use of Henna or 2-Hydroxy-1,4-naphoquinone(HNQ) for hair dyeing presents no or negligible risk of genotoxicity to the consumer. Chemical Properties Yellow crystal powder History Lawsone (CI Natural Orange 6; CI 75420), also known as henna and isojuglone, occurs in the shrub henna (Lawsone alba). In England, the plant is known as Egyptian privet. The dye was extracted from the leaves of the plant, using sodium bicarbonate, and the extracts used to dye protein fibers an orange shade. Henna is probably the oldest cosmetic known. The ancient Egyptians used it as a hair dye and for staining fingernails. It is said that Mohammed dyed his beard with henna. Lawsone has been identified as 2-hydroxy-1,4-naphthoquinone. It has been synthesized by the Thiele acetylation of 1,4-naphthoquinone followed by hydrolysis and oxidation. Uses 2-Hydroxy-1,4-naphthoquinone is used for preparing decorative hair and skin dyes. 2-Hydroxy-1,4-naphthoquinone also demonstrates antimicrobial and antioxidant effects. It also suppress the formation of hydrogen peroxide and superoxide radical anion by aldehyde oxidase-catalyzed reactions. Uses antifungal, sunscreen, antibacterial, antineoplastic Uses An antimicrobial antioxidant dye isolated from Henna. Definition A coloring principle obtained from dried leaves of certain tropical plants (North Africa, India). Synthesis Reference(s) The Journal of Organic Chemistry, 53, p. 808, 1988 DOI: 10.1021/jo00239a023 Tetrahedron Letters, 25, p. 533, 1984 DOI: 10.1016/S0040-4039(00)99930-1 General Description Yellow prisms or yellow powder. Air & Water Reactions Insoluble in water. Reactivity Profile Phenols, such as 2-Hydroxy-1,4-naphoquinone, do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid. Nitrated phenols often explode when heated. Many of them form metal salts that tend toward detonation by rather mild shock. Health Hazard ACUTE/CHRONIC HAZARDS: 2-Hydroxy-1,4-naphoquinone may be absorbed through the skin and can cause skin irritation. Fire Hazard Flash point data for 2-Hydroxy-1,4-naphoquinone are not available but 2-Hydroxy-1,4-naphoquinone is probably combustible. Contact allergens Henna, prepared by powdering the dried leaves of henna plant (Lawsonia inermis L.), is used for coloring and conditioning hair and nails, particularly by Muslims or Hindus. It contains Lawsone, which very rarely induces contact allergy. Most dermatitis caused by “black henna” is due to PPD and derivatives Purification Methods Crystallise Lawsone B from *C6H6 or AcOH (m 192.5o, 195-196o). It sublimes in a vacuum (m 194o). It has UV with max at 455nm (aqueous NaOH). [Beilstein 8 H 300, 8 I 635, 8 II 344, 8 III 2543, 8 IV 2360.]   2-Hydroxy-1,4-naphoquinone Preparation Products And Raw materials Raw materials Ammonium sulfamate-->1,4-Naphthoquinone-->1,2-NAPHTHOQUINONE-->naphthalene-1,2,4-triyl triacetate-->naphthalene-1,2,4-triol-->2-Naphthalenol, 1,4-dimethoxy--->1,3-DIHYDROXYNAPHTHALENE-->2-METHOXY-1,4-NAPHTHOQUINONE-->4-methoxynaphthalene-1,2-dione-->1,2-DIHYDROXYNAPHTHALENE-->2-Chloro-3-hydroxy-1,4-naphthoquinone-->2-hydroxy-3-iodonaphthalene-1,4-dione-->1,4-Dihydroxynaphthalene-->2-Naphthol-->1-Tetralone-->2-Methoxynaphthalene-->2-NITROTHIOPHENOL Preparation Products NILE RED-->2-Chloro-1,4-naphthoquinone Tag:2-Hydroxy-1,4-naphoquinone(83-72-7) Related Product Information