China Biggest Manufacturer factory sales Erythromycin Thiocyanate CAS 9001-00-7 CAS NO.9001-00-7

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Bromelain Basic information Product Name: Bromelain Synonyms: ananase;bromelains;CATHEPSIN B1;CATHEPSIN B (LIVER);BroMelain topical;Bromelain Powder 1200gdu/G;Bromelain Joyce;e.c.3.4.4.24 CAS: 9001-00-7 MF: N/A MW: 0 EINECS: 232-572-4 Product Categories:   Mol File: Mol File   Bromelain Chemical Properties storage temp.  −20°C form  powder color  yellow-brown Water Solubility  soluble CAS DataBase Reference 9001-00-7 EPA Substance Registry System Bromelain, juice (9001-00-7)   Safety Information Hazard Codes  B,Xn Risk Statements  36/37/38-42 Safety Statements  22-24-26-36/37-36/37/39 WGK Germany  3 F  10-21 HS Code  35079090 Hazardous Substances Data 9001-00-7(Hazardous Substances Data) MSDS Information Provider Language Bromelain English SigmaAldrich English ACROS English   Bromelain Usage And Synthesis Description Bromelain (EC 3.4.22.32) is a protease that is derived primarily from the stems of the pineapple plant ( Ananas comosus or Ananas bracteatus ), although it is found throughout the plant. Following fruit collection the stump is also harvested, peeled, crushed, and the liquid collected. Soluble bromelain is purified from the liquid via ultrafiltration followed by freeze drying or solvent precipitation and sold in powder form.  Chemical Properties yellow to beige crystalline powder Originator Ananase,Rorer,US,1962 Uses Bromelain is also used as a natural anti-inflammatory for conditions such as arthritis. It's one of the most popular supplements in Germany, where it is approved by the Commission E for the treatment of inflammation and swelling of the nose and sinuses du Uses Tenderizing meat, chill-proofing beer, production of protein hydrolyzates. Definition A milk-clotting proteolytic enzyme. It is precipitated from pineapple juice with acetone or ammonium sulfide. Manufacturing Process According to US Patent 3,002,891, the following describes pilot plant production of bromelain. Stripped pineapple stumps were passed four times through a three roll sugar mill press, In the second and following passes through the press, water was added to the pulp to increase the efficiency of the extraction procedure. The crude juice was screened to remove the coarse particles. Hydrogen sulfide gas was bled into the collected juice to partially saturate it. The pH was adjusted to pH 4.8 and then the juice was centrifuged. To 50 gallons of juice were added 30 gallons of cold acetone. The precipitate which formed was removed by centifuging in a Sharples centrifuge. This precipitate was discarded. To the supernatant liquor an additional 35 gallons of acetone was added and the precipitate was collected in a Sharples centrifuge. The wet precipitate was dropped into fresh acetone, mixed well, and then recovered by settling. The paste was then dried in a vacuum oven at a shelf temperature of 110°F. Yield: 8 pounds of enzyme per 100 gallons of juice. Activity: 4,000 MCU/g. Therapeutic Function Antiinflammatory General Description Bromelains (Ananase) is a mixture of proteolyticenzymes obtained from the pineapple plant. It isproposed for use in the treatment of soft-tissue inflammationand edema associated with traumatic injury, localized inflammation,and postoperative tissue reactions. Theswelling that accompanies inflammation may be caused byocclusion of the tissue spaces with fibrin. If this is true,enough Ananase would have to be absorbed and reach thetarget area after oral administration to act selectively on thefibrin. This is yet to be established, and its efficacy as ananti-inflammatory agent is inconclusive. An apparent inhibitionof inflammation, however, has been demonstratedwith irritants such as turpentine and croton oil (granulomapouch technique). Ananase is available in 50,000-U tabletsfor oral use. Biological Activity Bromelain powder is actually a collection of individual proteases with similar activities. Although lower than papain, bromelain still has a fairly high temperature of inactivation and broad pH activity range. Bromelain has been found to be more active against collagen proteins than papain or ficin (Fogle, Plimpton, Ockerman, Jarenback, & Persson, 1982 ; Kang & Rice, 1970) and effective at improving meat tenderness.   Bromelain Preparation Products And Raw materials Raw materials KAOLIN-->PINEAPPLE JUICE-->Acetone

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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                                                       Product information

Bromelain Basic information Product Name: Bromelain Synonyms: ananase;bromelains;CATHEPSIN B1;CATHEPSIN B (LIVER);BroMelain topical;Bromelain Powder 1200gdu/G;Bromelain Joyce;e.c.3.4.4.24 CAS: 9001-00-7 MF: N/A MW: 0 EINECS: 232-572-4 Product Categories:   Mol File: Mol File   Bromelain Chemical Properties storage temp.  −20°C form  powder color  yellow-brown Water Solubility  soluble CAS DataBase Reference 9001-00-7 EPA Substance Registry System Bromelain, juice (9001-00-7)   Safety Information Hazard Codes  B,Xn Risk Statements  36/37/38-42 Safety Statements  22-24-26-36/37-36/37/39 WGK Germany  3 F  10-21 HS Code  35079090 Hazardous Substances Data 9001-00-7(Hazardous Substances Data) MSDS Information Provider Language Bromelain English SigmaAldrich English ACROS English   Bromelain Usage And Synthesis Description Bromelain (EC 3.4.22.32) is a protease that is derived primarily from the stems of the pineapple plant ( Ananas comosus or Ananas bracteatus ), although it is found throughout the plant. Following fruit collection the stump is also harvested, peeled, crushed, and the liquid collected. Soluble bromelain is purified from the liquid via ultrafiltration followed by freeze drying or solvent precipitation and sold in powder form.  Chemical Properties yellow to beige crystalline powder Originator Ananase,Rorer,US,1962 Uses Bromelain is also used as a natural anti-inflammatory for conditions such as arthritis. It's one of the most popular supplements in Germany, where it is approved by the Commission E for the treatment of inflammation and swelling of the nose and sinuses du Uses Tenderizing meat, chill-proofing beer, production of protein hydrolyzates. Definition A milk-clotting proteolytic enzyme. It is precipitated from pineapple juice with acetone or ammonium sulfide. Manufacturing Process According to US Patent 3,002,891, the following describes pilot plant production of bromelain. Stripped pineapple stumps were passed four times through a three roll sugar mill press, In the second and following passes through the press, water was added to the pulp to increase the efficiency of the extraction procedure. The crude juice was screened to remove the coarse particles. Hydrogen sulfide gas was bled into the collected juice to partially saturate it. The pH was adjusted to pH 4.8 and then the juice was centrifuged. To 50 gallons of juice were added 30 gallons of cold acetone. The precipitate which formed was removed by centifuging in a Sharples centrifuge. This precipitate was discarded. To the supernatant liquor an additional 35 gallons of acetone was added and the precipitate was collected in a Sharples centrifuge. The wet precipitate was dropped into fresh acetone, mixed well, and then recovered by settling. The paste was then dried in a vacuum oven at a shelf temperature of 110°F. Yield: 8 pounds of enzyme per 100 gallons of juice. Activity: 4,000 MCU/g. Therapeutic Function Antiinflammatory General Description Bromelains (Ananase) is a mixture of proteolyticenzymes obtained from the pineapple plant. It isproposed for use in the treatment of soft-tissue inflammationand edema associated with traumatic injury, localized inflammation,and postoperative tissue reactions. Theswelling that accompanies inflammation may be caused byocclusion of the tissue spaces with fibrin. If this is true,enough Ananase would have to be absorbed and reach thetarget area after oral administration to act selectively on thefibrin. This is yet to be established, and its efficacy as ananti-inflammatory agent is inconclusive. An apparent inhibitionof inflammation, however, has been demonstratedwith irritants such as turpentine and croton oil (granulomapouch technique). Ananase is available in 50,000-U tabletsfor oral use. Biological Activity Bromelain powder is actually a collection of individual proteases with similar activities. Although lower than papain, bromelain still has a fairly high temperature of inactivation and broad pH activity range. Bromelain has been found to be more active against collagen proteins than papain or ficin (Fogle, Plimpton, Ockerman, Jarenback, & Persson, 1982 ; Kang & Rice, 1970) and effective at improving meat tenderness.   Bromelain Preparation Products And Raw materials Raw materials KAOLIN-->PINEAPPLE JUICE-->Acetone