China Original Largest Manufacturer sales Ribonuclease/Rnase/ Ribonuclease A CAS 9001-99-4 CAS NO.9001-99-4

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Ribonuclease A Basic information Product Name: Ribonuclease A Synonyms: Ribonuclease A froM bovine pancreas Min. 70 Kunitz units/Mg lyophil.;Ribonuclease A froM bovine pancreas Min. 80 Kunitz units/Mg lyophil.;Ribonuclease A froM bovine pancreas(Purified);Ribonuclease A from bovine pancreas Vetec(TM) reagent grade, 80%;bonuclease A;O-PHENYLENEDIAMINE REAGENT GRADE;RIBONUCLEASE A FROM BOVINE PANCREAS, POW DER, ~80 U/MG;RIBONUCLEASE A SOLUTION MOLECULAR*BIOLOG Y REAGENT CAS: 9001-99-4 MF: NULL MW: 0 EINECS: 232-646-6 Product Categories: General Metabolic Enzymes;Metabolomics;Enzyme Class Index;3.x.x.x Hydrolases;Others;Nucleotide Metabolism;Nucleic acids;Ribonuclease A Mol File: Mol File   Ribonuclease A Chemical Properties Melting point  243 °C (dec.) alpha  D25 (per mg N) -0.47° (c = 5) storage temp.  -20°C solubility  Reconstitute in 10mM acetate, pH 5.0 with or without 15mM calcium chloride form  solid color  white PH pH : 8.0 Water Solubility  Soluble in water. Sensitive  Moisture Sensitive EPA Substance Registry System Nuclease, ribo- (9001-99-4)   Safety Information Safety Statements  22-24/25 WGK Germany  3 RTECS  RF0760000 F  10-21 TSCA  Yes HS Code  35079090 MSDS Information Provider Language Alkaline ribonuclease English SigmaAldrich English   Ribonuclease A Usage And Synthesis Chemical Properties Lyophilized Uses Ribonuclease A is used to remove RNA from DNA plasmid preparations and protein samples. Ribonuclease A is used for RNase protection assays, to remove unspecifically bound RNA, analysis of RNA sequences, to hydrolyze RNA contained in protein samples, and the purification of DNA.Ribonuclease A from bovine pancreas has been used in a study to assess hybridase activity of human ribonuclease-1. Ribonuclease A from bovine pancreas has also been used in a study to investigate particle-based and monolithic columns for cation exchange protein displacement chromatography. Uses Ribonuclease A is used to remove RNA from DNA plasmid preparations and protein samples. Ribonuclease A is used for RNase protection assays, to remove unspecifically bound RNA, analysis of RNA sequences, to hydrolyze RNA contained in protein samples, and the purification of DNA. Ribonuclease A from bovine pancreas has been used in a study to assess the mechanism of heavy metal ions on RNase activity. Ribonuclease A from bovine pancreas has also been used in a study to investigate the performance of oligomeric poly(diallyldimethylammonium chloride) as displacer for cation-exchange displacement chromatography of proteins. Uses Ribonuclease A (RNase A) is a pancreatic ribonuclease that cleaves single-stranded RNA. RNase A, and several homologs, may be useful as cancer therapeutics due to their cytotoxic effects on cancer cells. Rnase A is useful in the elucidation of protein structure and absorbance. RNase A has been used as a model system in the study of computer-aided drug design . Product R2638 has scrambled disulfide bonds and is from bovine pancreas. General Description Human chromosome 14q11.2 shows the presence of all human RNases. Only eight (RNase 1-8) of them were true called as canonical RNases. And the rest nine to thirteen are called as noncanonical RNases. Human RNase 1 is called as HP-RNase or human pancreatic RNase. Human RNase 2 is also called as EDN (eosinophils derived neurotoxin) that is isolated from eosinophils. Biochem/physiol Actions Ribonuclease A is an endoribonuclease that cleaves single stranded RNA after pyrimidine nucleotides. It attacks at the 3′ phosphate end. Ribonucleases do not hydrolyze DNA, because the DNA lacks 2′-OH groups essential for the formation of cyclic intermediates. RNase can also hydrolyze RNA from protein samples. RNase A can be inhibited by alkylation of His12 and His119 and activated by potassium and sodium salts. Purification Methods Purify it by (NH4)2SO4 fractionation, followed by PC cellulose chromatography and affinity chromatography (using Sepharose 4B to which (G)n is covalently bonded). [Schmukler et al. J Biol Chem 250 2206 1975.] Ribozymes. These are ribonucleic acids which act like protein enzyme in catalyzing the making and breaking of peptide bonds as well as catalyzing reactions and cleavage of DNA and RNA molecules. The short RNAs are being intensively studied (see RNAi below). MicroRNAs (miRNA, see also below) are ubiquitous and are also genetically produced. They are involved in numerous reactions from splicing RNA, e.g. mRNA (messenger RNA) to controlling transcription of DNA to RNA, and translation of RNA to protein. Each miRNA is capable of being involved in a small number to hundreds of interactions with nucleic acids and with proteins.   Ribonuclease A Preparation Products And Raw materials Raw materials Ammonium sulfate-->Erythromycin

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Ribonuclease A Basic information Product Name: Ribonuclease A Synonyms: Ribonuclease A froM bovine pancreas Min. 70 Kunitz units/Mg lyophil.;Ribonuclease A froM bovine pancreas Min. 80 Kunitz units/Mg lyophil.;Ribonuclease A froM bovine pancreas(Purified);Ribonuclease A from bovine pancreas Vetec(TM) reagent grade, 80%;bonuclease A;O-PHENYLENEDIAMINE REAGENT GRADE;RIBONUCLEASE A FROM BOVINE PANCREAS, POW DER, ~80 U/MG;RIBONUCLEASE A SOLUTION MOLECULAR*BIOLOG Y REAGENT CAS: 9001-99-4 MF: NULL MW: 0 EINECS: 232-646-6 Product Categories: General Metabolic Enzymes;Metabolomics;Enzyme Class Index;3.x.x.x Hydrolases;Others;Nucleotide Metabolism;Nucleic acids;Ribonuclease A Mol File: Mol File   Ribonuclease A Chemical Properties Melting point  243 °C (dec.) alpha  D25 (per mg N) -0.47° (c = 5) storage temp.  -20°C solubility  Reconstitute in 10mM acetate, pH 5.0 with or without 15mM calcium chloride form  solid color  white PH pH : 8.0 Water Solubility  Soluble in water. Sensitive  Moisture Sensitive EPA Substance Registry System Nuclease, ribo- (9001-99-4)   Safety Information Safety Statements  22-24/25 WGK Germany  3 RTECS  RF0760000 F  10-21 TSCA  Yes HS Code  35079090 MSDS Information Provider Language Alkaline ribonuclease English SigmaAldrich English   Ribonuclease A Usage And Synthesis Chemical Properties Lyophilized Uses Ribonuclease A is used to remove RNA from DNA plasmid preparations and protein samples. Ribonuclease A is used for RNase protection assays, to remove unspecifically bound RNA, analysis of RNA sequences, to hydrolyze RNA contained in protein samples, and the purification of DNA.Ribonuclease A from bovine pancreas has been used in a study to assess hybridase activity of human ribonuclease-1. Ribonuclease A from bovine pancreas has also been used in a study to investigate particle-based and monolithic columns for cation exchange protein displacement chromatography. Uses Ribonuclease A is used to remove RNA from DNA plasmid preparations and protein samples. Ribonuclease A is used for RNase protection assays, to remove unspecifically bound RNA, analysis of RNA sequences, to hydrolyze RNA contained in protein samples, and the purification of DNA. Ribonuclease A from bovine pancreas has been used in a study to assess the mechanism of heavy metal ions on RNase activity. Ribonuclease A from bovine pancreas has also been used in a study to investigate the performance of oligomeric poly(diallyldimethylammonium chloride) as displacer for cation-exchange displacement chromatography of proteins. Uses Ribonuclease A (RNase A) is a pancreatic ribonuclease that cleaves single-stranded RNA. RNase A, and several homologs, may be useful as cancer therapeutics due to their cytotoxic effects on cancer cells. Rnase A is useful in the elucidation of protein structure and absorbance. RNase A has been used as a model system in the study of computer-aided drug design . Product R2638 has scrambled disulfide bonds and is from bovine pancreas. General Description Human chromosome 14q11.2 shows the presence of all human RNases. Only eight (RNase 1-8) of them were true called as canonical RNases. And the rest nine to thirteen are called as noncanonical RNases. Human RNase 1 is called as HP-RNase or human pancreatic RNase. Human RNase 2 is also called as EDN (eosinophils derived neurotoxin) that is isolated from eosinophils. Biochem/physiol Actions Ribonuclease A is an endoribonuclease that cleaves single stranded RNA after pyrimidine nucleotides. It attacks at the 3′ phosphate end. Ribonucleases do not hydrolyze DNA, because the DNA lacks 2′-OH groups essential for the formation of cyclic intermediates. RNase can also hydrolyze RNA from protein samples. RNase A can be inhibited by alkylation of His12 and His119 and activated by potassium and sodium salts. Purification Methods Purify it by (NH4)2SO4 fractionation, followed by PC cellulose chromatography and affinity chromatography (using Sepharose 4B to which (G)n is covalently bonded). [Schmukler et al. J Biol Chem 250 2206 1975.] Ribozymes. These are ribonucleic acids which act like protein enzyme in catalyzing the making and breaking of peptide bonds as well as catalyzing reactions and cleavage of DNA and RNA molecules. The short RNAs are being intensively studied (see RNAi below). MicroRNAs (miRNA, see also below) are ubiquitous and are also genetically produced. They are involved in numerous reactions from splicing RNA, e.g. mRNA (messenger RNA) to controlling transcription of DNA to RNA, and translation of RNA to protein. Each miRNA is capable of being involved in a small number to hundreds of interactions with nucleic acids and with proteins.   Ribonuclease A Preparation Products And Raw materials Raw materials Ammonium sulfate-->Erythromycin