China Largest Factory Manufacturer sales USP, BP, EP, CP Cellulose Microcrystalline CAS 9004-34-6 CAS NO.9004-34-6

FOB Price: USD: 1.00-2.00 /Kilogram Get Latest Price
Min.Order: 1 Kilogram
Payment Terms: L/C,D/A,D/P,T/T,Other
Available Specifications:
AAAAA(50-100)Kilogram1/Kilogram50USDAAAAA(100-500)Kilogram2/Kilogram100USD

Product Details

Keywords

Cellulose Microcrystalline
Cellulose Microcrystalline
9004-34-6

Quick Details

ProName: China Largest Factory Manufacturer sal...
CasNo: 9004-34-6
Molecular Formula: 9004-34-6
Appearance: white powder
Application: Pharm chemicals industry
DeliveryTime: 3-5 days
PackAge: 25KG/Drum
Port: Shanghai Guangzhou Qingdao Shenzhen
ProductionCapacity: 20 Metric Ton/Month
Purity: 99%
Storage: 2-8°C
Transportation: By air /Sea/ coruier
LimitNum: 1 Kilogram
Heavy metal: 10PPM
Grade: Industrial Grade,Food Grade,Pharma Gra...
Color: white
Melting point: ≥350°C
Boiling point: 363.24°C (rough estimate)
density: 1.667
solubility: 1 M NaOH: 10 mg/mL, dark green
Water Solubility: <0.1 g/100 mL at 21 oC
Stability: Stable. Combustible. Incompatible with...

Superiority

PRODUCT DETAILS

Item	USP/BP/EP	CP
Identification	Conforms
Solubility	Conforms
pH	5.0-7.5	5.0-7.5
Ether-soluble Substances (%)	≤0.05	≤0.05
Water-soluble Substances (%)	≤0.25	≤0.2
Residue on Ignition/ Sulfated ash (%)	≤0.1	≤0.1
Loss on drying (%)	≤7.0	≤7.0
Bulk Density (g/cm3)	Conforms	——
Conductivity（µS/cm）	≤75	≤75
Chlorides （%）	——	≤0.03
Starch	——	Conforms
Arsenic (%)	——	≤0.0002
Heavy metal (%)	——	≤0.001
Particle Size: Retained 60 mesh (250microns) (%) Retained 200 mesh (74 microns）(%)	≤1.0 ≤30.0	——
Microbial limits	Conforms

Cas No. 9004-34-6 H.S. Code 39129000

Main Purpose: Tablet and capsule diluent; tablet disintegrant.

Package: 20kg/kraft bag or 20kg/fiber drum

Packing Size: 2.2cbm/mt(bag) or D37cm*H53cm(drum)

G.W. 20.2kg(bag) or 22.5kg(drum)

Microcrystalline cellulose Basic information Product Name: Microcrystalline cellulose Synonyms: AVICEL PH;AVICEL PH 101(R);AVICEL PH 102;AVICEL PH 105(R);AVICEL(R);''AVICEL(R)'';AVICEL SF;AVIRIN CAS: 9004-34-6 MF: (C12H20O10)n MW: 324.28 EINECS: 232-674-9 Product Categories: CarbohydrateSerum-free Media;Companion Products and Reagents;Nutritional Supplements;Insect Platform;Metabolic Pathways;Metabolites and Cofactors on the Metabolic Pathways Chart;Carbohydrate;Cellulose;Materials Science;Natural Polymers;Polymer Science;Polymers;API Mol File: 9004-34-6.mol Microcrystalline cellulose Chemical Properties Melting point 76-78 °C(Solv: acetone (67-64-1); chloroform (67-66-3)) density 1.5 g/cm3 (20℃) refractive index n20/D 1.504 Fp 164 °C storage temp. room temp solubility Practically insoluble in water, in acetone, in anhydrous ethanol, in toluene, in dilute acids and in a 50 g/L solution of sodium hydroxide form powder color White or almost white PH 5-7.5 (100g/l, H2O, 20℃)(slurry) Odor Odorless Water Solubility insoluble Merck 14,1965 Stability: Stable. Combustible. Incompatible with strong oxidizing agents. InChIKey UFHFLCQGNIYNRP-UHFFFAOYSA-N EPA Substance Registry System Cellulose (9004-34-6) Safety Information Hazard Codes Xi Risk Statements 37 Safety Statements 24/25 WGK Germany 3 RTECS FJ5950200 F 3 Autoignition Temperature 232 °C TSCA Yes HS Code 39129090 Toxicity LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg MSDS Information Provider Language Cellulose microcrystalline English SigmaAldrich English ACROS English ALFA English Microcrystalline cellulose Usage And Synthesis Chemical Properties Microcrystalline cellulose and carboxymethylcellulose sodium occurs as a white or off-white odorless and tasteless hygroscopic powder containing 5–22% sodium carboxymethylcellulose. It is a water-dispersible organic hydrocolloid. Chemical Properties Microcrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. It is commercially available in different particle sizes and moisture grades that have different properties and applications. Occurrence The fiber in typical paper can be called “cellulosic”, meaning that cellulose is its most prominent component. Cellulose is present not only in wood, but also in various non-woody plants, such as straw, sugarcane (bagasse), reeds, and hemp. Uses High purity cellulose powders for partition chromatography. Uses ACCEL-101 is most widely used for direct compression tableting and wet granulation. ACCEL-102 has similar compression properties to ACCEL-101. However, it has larger particle size and therefore, may be of value in improving the flow if fine powders. ACCEL Uses cellulose is a thickener and an emulsifier. It is obtained from plants. cellulose (microcrystalline) is used as an emulsifier in cosmetic creams. It is the chief constituent of plant fiber. Uses Wood contains 50–70% cellulose; cotton and other textile fibers of plant origin contain 65–95%; rayon is prepared by dissolving natural cellulose and then precipitating it from solution, with some loss of crystallinity. Cellulose is made into cellophane film and is used to form fibers, resins, coatings and gums. Uses Cellulose is a carbohydrate polymer made up of glucose units. It consists of fibrous particles and is used as a fiber source and bulking agent in low-calorie formulations. Uses Microcrystalline Cellulose is a gum that is the nonfibrous form of cellulose, an alpha-cellulose. It is dispersible in water but not soluble, requiring considerable energy to disperse and hydrate. In this form it is used in dry applications such as tableting, capsules, and shredded cheese where it functions as a non-nutritive filler, binder, flow aid, and anticaking agent. By the addition of carboxymethylcellulose to the alpha-cellulose prior to drying, improved functional properties of hydration and dispersion are obtained. This product is designed for use in water dispersions, being insoluble in water but dispersing in water to form colloidal sols below 1% and white opaque gels above the 1% usage level. It is used as a heat shock stabilizer and bodying agent in frozen desserts, as an opacifier in low-fat dressings, as a foam stabilizer in whipped toppings, and as an emulsifier in dressings. Also termed cellulose gel. Definition A natural carbohydrate high polymer (polysaccha- ride) consisting of anhydroglucose units joined by an oxygen linkage to form long molecular chains that are essentially linear. It can be hydrolyzed to glucose. The degree of polymerization is from 1000 for wood pulp to 3500 for cotton fiber, giving a molecular weight from 160,000 to 560,000. Cellulose is a colorless solid, d approximately 1.50, insoluble in water and organic solvents. It will swell in sodium hydroxide solution and is soluble in Schweitzer’s reagent. It is the fundamental con- stituent of all vegetable tissues (wood, grass, cotton, etc.) and the most abundant organic material in the world. Cotton fibers are almost pure cellulose; wood contains approximately 50%. The physical structure of cellulose is unusual in that it is not a single crystal but consists of crystalline areas embedded in amorphous areas. Chemical reagents penetrate the latter more easily than the former. Cel- lulose is virtually odorless and tasteless and is com- bustible, with an ignition point of approximately 450F. In some forms, it is flammable. For example, railroad shipping regulations require a flammable label on such items as burnt fiber, burnt cotton, wet waste paper, and wet textiles. Fires have been known to occur in warehouses in which telephone books were stored. These were undoubtedly due to heat buildup in the paper caused by microbial activity and self-sustaining oxidation. Production Methods Microcrystalline cellulose and carboxymethylcellulose sodium is a spray- or bulk-dried blend of microcrystalline cellulose and sodium carboxymethylcellulose. It is prepared by the chemical depolymerization of highly purified wood pulp. The original crystalline areas of the pulp fibers are combined with sodium carboxymethylcellulose, which serves as a protective colloid and also facilitates dispersion of the product; it is then either spray- or bulk-dried. Production Methods Microcrystalline cellulose is manufactured by controlled hydrolysis with dilute mineral acid solutions of α-cellulose, obtained as a pulp from fibrous plant materials. Following hydrolysis, the hydrocellulose is purified by filtration and the aqueous slurry is spraydried to form dry, porous particles of a broad size distribution. General Description Odorless, white powdery fibers. Density 1.5 g cm-3. The biopolymer composing the cell wall of vegetable tissues. Prepared by treating cotton with an organic solvent to de-wax Cellulose microcrystalline and removing pectic acids by extration with a solution of sodium hydroxide. The principal fiber composing the cell wall of vegetable tissues (wood, cotton, flax, grass, etc.). Technical uses depend on the strength and flexibility of its fibers. Insoluble in water. Soluble with chemical degradation in sulfuric aicd, and in concentrated solutions of zinc chloride. Soluble in aqueous solutions of cupric ammonium hydroxide (Cu(NH3)4(OH)2). Reactivity Profile Cellulose microcrystalline is combustible. Incompatible with strong oxidizing agents including bromine pentafluoride, sodium nitrate, fluorine, perchlorates, perchloric acid, sodium chlorate, magnesium perchlorate, F2, zinc permanganate, sodium nitrite, sodium nitrate, sodium peroxide. Nitration with a mixture of nitric and sulfuric acids produces Cellulose microcrystalline nitrates (celluloid pyroxylin, soluble pyroxyline, guncotton) which are flammable or explosive. Health Hazard Cellulose is inert and is classified as a nuisance dust. It has little, if any, adverse effect on the lung, and there are no reports of organic disease or toxic effect. The health effects attributed to wood, cotton, flax, jute, and hemp are not attributable to their cellulose content but rather to the presence of other substances. Cellulose fibers were found in the blood and urine of human volunteers fed dyed cellulose; there were no ill effects. Pharmaceutical Applications Microcrystalline cellulose and carboxymethylcellulose sodium is used to produce thixotropic gels suitable as suspending vehicles in pharmaceutical and cosmetic formulations. The sodium carboxymethylcellulose aids dispersion and serves as a protective colloid. Concentrations of less than 1% solids produce fluid dispersions, while concentrations of more than 1.2% solids produce thixotropic gels. When properly dispersed, it imparts emulsion stability, opacity and suspension in a variety of products, and is used in nasal sprays, topical sprays and lotions, oral suspensions, emulsions, creams and gels. Industrial uses Cellulose is the main constituent of the structureof plants (natural polymer) that, whenextracted, is employed for making paper,plastics, and in many combinations. Celluloseis made up of long-chain molecules inwhich the complex unit C6H10O5 is repeatedas many as 2000 times. It consists of glucose molecules with three hydroxyl groups foreach glucose unit. One of the simplest forms of cellulose usedindustrially is regenerated cellulose, in whichthe chemical composition of the finished productis similar to that of the original cellulose. Itis made from wood or cotton pulp digested ina caustic solution. Cellophane is a regeneratedcellulose in thin sheets for wrapping and otherspecial uses include windings on wire andcable. Biochem/physiol Actions Cellulose helps in maintaining the structural stability of plant cell walls. It is an important component of paper and fabrics made from cotton, and linen. Safety Profile A nuisance dust. When heated to decomposition it emits acrid smoke and irritating fumes. Safety Microcrystalline cellulose is widely used in oral pharmaceutical formulations and food products and is generally regarded as a relatively nontoxic and nonirritant material. Microcrystalline cellulose is not absorbed systemically following oral administration and thus has little toxic potential. Consumption of large quantities of cellulose may have a laxative effect, although this is unlikely to be a problem when cellulose is used as an excipient in pharmaceutical formulations. Deliberate abuse of formulations containing cellulose, either by inhalation or by injection, has resulted in the formation of cellulose granulomas. storage Microcrystalline cellulose and carboxymethylcellulose sodium is hygroscopic and should not be exposed to moisture. It is stable over a pH range of 3.5–11. Store in a cool, dry place. Avoid exposure to excessive heat. Incompatibilities Microcrystalline cellulose is incompatible with strong oxidizing agents. Regulatory Status Microcrystalline cellulose and carboxymethylcellulose sodium is a mixture of two materials both of which are generally regarded as nontoxic: Microcrystalline cellulose GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; oral capsules, powders, suspensions, syrups, and tablets; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Carboxymethylcellulose sodium GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; intra-articular, intrabursal, intradermal, intralesional, and intrasynovial injections; oral drops, solutions, suspensions, syrups and tablets; topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients. Microcrystalline cellulose Preparation Products And Raw materials Raw materials Sucrose-->Defatted cotton-->COTTONSEED OIL-->LIGNINE Preparation Products Potassium chloride-->Polyinosinic acid-polycytidylic acid-->Sodium carboxymethyl cellulose-->naphtha steam reforming catalysts-->Hydroxypropyl methyl cellulose-->D(+)-Xylose-->Tirofiban-->Ethyl cellulose-->LIGNINE-->TAMARIND GUM-->biodegrddable finishing agent for fabric-->Dispersant CS

About Our Group

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research. Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products. Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation. We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Product information

Item	USP/BP/EP	CP
Identification	Conforms
Solubility	Conforms
pH	5.0-7.5	5.0-7.5
Ether-soluble Substances (%)	≤0.05	≤0.05
Water-soluble Substances (%)	≤0.25	≤0.2
Residue on Ignition/ Sulfated ash (%)	≤0.1	≤0.1
Loss on drying (%)	≤7.0	≤7.0
Bulk Density (g/cm3)	Conforms	——
Conductivity（µS/cm）	≤75	≤75
Chlorides （%）	——	≤0.03
Starch	——	Conforms
Arsenic (%)	——	≤0.0002
Heavy metal (%)	——	≤0.001
Particle Size: Retained 60 mesh (250microns) (%) Retained 200 mesh (74 microns）(%)	≤1.0 ≤30.0	——
Microbial limits	Conforms