China Largest Manufacturer factory Supply Ethyl Cellulose CAS 9004-57-3 CAS NO.9004-57-3

                                PRODUCT DETAILS       

Cas No. 9004-57-3  H.S. Code 39129000

Main Purpose: Tablet binder,filler,thickener.

Package: 12.5kg/fiber drum

G.W. 15kg

Ethyl cellulose Basic information Product Name: Ethyl cellulose Synonyms: ampacete/c;aquacoat;aquacoatecd30;aquacoatecd30fmc;cellulose,triethylether;celluloseethyl;nixone/c;spt50cps CAS: 9004-57-3 MF: C23H24N6O4 MW: 448.47446 EINECS: 618-384-9 Product Categories: Cellulose;Materials Science;Natural Polymers;Polymer Science;Polymers Mol File: 9004-57-3.mol   Ethyl cellulose Chemical Properties Melting point  240-255 °C density  1.14 g/mL at 25 °C (lit.) refractive index  n20/D 1.47(lit.) storage temp.  2-8°C solubility  esters, aromatic hydrocarbons, alcohols and ketones: soluble form  powder Specific Gravity 1.14 color  White to slightly yellow Water Solubility  insoluble Merck  14,3781 EPA Substance Registry System Ethyl cellulose (9004-57-3)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  1 RTECS  FJ5950500 F  3 Autoignition Temperature 698 °F TSCA  Yes HS Code  39129000 Hazardous Substances Data 9004-57-3(Hazardous Substances Data) MSDS Information Provider Language Ethyl cellulose English SigmaAldrich English ACROS English   Ethyl cellulose Usage And Synthesis Chemical Properties white to slightly yellowish powder Chemical Properties Ethylcellulose is a tasteless, free-flowing, white to light tan-colored powder. Uses ethyl cellulose is a binder, film former, and thickener. It is used in suntan gels, creams, and lotions. This is the ethyl ether of cellulose. Uses Film-former in coatings, hot-melt adhesives and transfer inks and as a plastic coating for a variety of substrates. Uses In the manufacture of plastics and lacquers. Pharmaceutic aid (tablet binder). Uses Used as a binder and filler in dry vitamin preparations, as a component of protective coatings for vitamin and mineral tablets, and as a fixative in flavoring compounds. It is a cellulose ether containing ethyoxy groups attached by an ether linkage and containing an anhydrous basis of not more than 2.6 ethoxy groups per anhydroglucose unit. Production Methods Ethylcellulose is prepared by treating purified cellulose (sourced from chemical-grade cotton linters and wood pulp) with an alkaline solution, followed by ethylation of the alkali cellulose with chloroethane as shown below, where R represents the cellulose radical: RONa + C2H5Cl→ROC2H5+NaCl The manner in which the ethyl group is added to cellulose can be described by the degree of substitution (DS). The DS designates the average number of hydroxyl positions on the anhydroglucose unit that have been reacted with ethyl chloride. Since each anhydroglucose unit of the cellulose molecule has three hydroxyl groups, the maximum value for DS is three. Preparation Ethyl cellulose is prepared by reacting cellulose with caustic to form caustic cellulose, which is then reacted with chloroethane to form ethyl cellulose. Plasticgrade material contains 44-48% ethoxyl. Although not as resistant as cellulose esters to acids, it is much more resistant to bases. An outstanding feature is its toughness at low temperatures. Brand name Aquacoat ECD (FMC);Ethocel (Dow Chemical). Pharmaceutical Applications Ethylcellulose is widely used in oral and topical pharmaceutical formulations. The main use of ethylcellulose in oral formulations is as a hydrophobic coating agent for tablets and granules.Ethylcellulose coatings are used to modify the release of a drug, to mask an unpleasant taste, or to improve the stability of a formulation; for example, where granules are coated with ethylcellulose to inhibit oxidation. Modified-release tablet formulations may also be produced using ethylcellulose as a matrix former. Ethylcellulose, dissolved in an organic solvent or solvent mixture, can be used on its own to produce water-insoluble films. Higher-viscosity ethylcellulose grades tend to produce stronger and more durable films. Ethylcellulose films may be modified to alter their solubility, by the addition of hypromellose or a plasticizer. An aqueous polymer dispersion (or latex) of ethylcellulose such as Aquacoat ECD (FMC Biopolymer) or Surelease (Colorcon) may also be used to produce ethylcellulose films without the need for organic solvents. Drug release through ethylcellulose-coated dosage forms can be controlled by diffusion through the film coating. This can be a slow process unless a large surface area (e.g. pellets or granules compared with tablets) is utilized. In those instances, aqueous ethylcellulose dispersions are generally used to coat granules or pellets. Ethylcellulose-coated beads and granules have also demonstrated the ability to absorb pressure and hence protect the coating from fracture during compression. High-viscosity grades of ethylcellulose are used in drug microencapsulation. Release of a drug from an ethylcellulose microcapsule is a function of the microcapsule wall thickness and surface area. In tablet formulations, ethylcellulose may additionally be employed as a binder, the ethylcellulose being blended dry or wetgranulated with a solvent such as ethanol (95%). Ethylcellulose produces hard tablets with low friability, although they may demonstrate poor dissolution. Ethylcellulose has also been used as an agent for delivering therapeutic agents from oral (e.g. dental) appliances. In topical formulations, ethylcellulose is used as a thickening agent in creams, lotions, or gels, provided an appropriate solvent is used. Ethylcellulose has been studied as a stabilizer for emulsions. Ethylcellulose is additionally used in cosmetics and food products. Safety Profile Low toxicity by ingestion and skin contact. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes Safety Ethylcellulose is widely used in oral and topical pharmaceutical formulations. It is also used in food products. Ethylcellulose is not metabolized following oral consumption and is therefore a noncalorific substance. Because ethylcellulose is not metabolized it is not recommended for parenteral products; parenteral use may be harmful to the kidneys. Ethylcellulose is generally regarded as a nontoxic, nonallergenic, and nonirritating material. As ethylcellulose is not considered to be a health hazard, the WHO has not specified an acceptable daily intake. The highest reported level used in an oral product is 308.8 mg in an oral sustained release tablet. LD50 (rabbit, skin): >5 g/kg LD50 (rat, oral): >5 g/kg storage Ethylcellulose is a stable, slightly hygroscopic material. It is chemically resistant to alkalis, both dilute and concentrated, and to salt solutions, although it is more sensitive to acidic materials than are cellulose esters. Ethylcellulose is subject to oxidative degradation in the presence of sunlight or UV light at elevated temperatures. This may be prevented by the use of antioxidant and chemical additives that absorb light in the 230–340nm range. Ethylcellulose should be stored at a temperature not exceeding 32°C (90°F) in a dry area away from all sources of heat. It should not be stored next to peroxides or other oxidizing agents. Incompatibilities Incompatible with paraffin wax and microcrystalline wax. Regulatory Status GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules, suspensions and tablets; topical emulsions and vaginal preparations). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.   Ethyl cellulose Preparation Products And Raw materials Raw materials CHLOROETHANE-->Dehydrolyzing agent-->Microcrystalline cellulose Preparation Products Carbendazim-->PENTYL ETHER-->scavenger of fabric maculae

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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                                                       Product information

Cas No. 9004-57-3  H.S. Code 39129000

Main Purpose: Tablet binder,filler,thickener.

Package: 12.5kg/fiber drum

G.W. 15kg

Ethyl cellulose Basic information Product Name: Ethyl cellulose Synonyms: ampacete/c;aquacoat;aquacoatecd30;aquacoatecd30fmc;cellulose,triethylether;celluloseethyl;nixone/c;spt50cps CAS: 9004-57-3 MF: C23H24N6O4 MW: 448.47446 EINECS: 618-384-9 Product Categories: Cellulose;Materials Science;Natural Polymers;Polymer Science;Polymers Mol File: 9004-57-3.mol   Ethyl cellulose Chemical Properties Melting point  240-255 °C density  1.14 g/mL at 25 °C (lit.) refractive index  n20/D 1.47(lit.) storage temp.  2-8°C solubility  esters, aromatic hydrocarbons, alcohols and ketones: soluble form  powder Specific Gravity 1.14 color  White to slightly yellow Water Solubility  insoluble Merck  14,3781 EPA Substance Registry System Ethyl cellulose (9004-57-3)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  1 RTECS  FJ5950500 F  3 Autoignition Temperature 698 °F TSCA  Yes HS Code  39129000 Hazardous Substances Data 9004-57-3(Hazardous Substances Data) MSDS Information Provider Language Ethyl cellulose English SigmaAldrich English ACROS English   Ethyl cellulose Usage And Synthesis Chemical Properties white to slightly yellowish powder Chemical Properties Ethylcellulose is a tasteless, free-flowing, white to light tan-colored powder. Uses ethyl cellulose is a binder, film former, and thickener. It is used in suntan gels, creams, and lotions. This is the ethyl ether of cellulose. Uses Film-former in coatings, hot-melt adhesives and transfer inks and as a plastic coating for a variety of substrates. Uses In the manufacture of plastics and lacquers. Pharmaceutic aid (tablet binder). Uses Used as a binder and filler in dry vitamin preparations, as a component of protective coatings for vitamin and mineral tablets, and as a fixative in flavoring compounds. It is a cellulose ether containing ethyoxy groups attached by an ether linkage and containing an anhydrous basis of not more than 2.6 ethoxy groups per anhydroglucose unit. Production Methods Ethylcellulose is prepared by treating purified cellulose (sourced from chemical-grade cotton linters and wood pulp) with an alkaline solution, followed by ethylation of the alkali cellulose with chloroethane as shown below, where R represents the cellulose radical: RONa + C2H5Cl→ROC2H5+NaCl The manner in which the ethyl group is added to cellulose can be described by the degree of substitution (DS). The DS designates the average number of hydroxyl positions on the anhydroglucose unit that have been reacted with ethyl chloride. Since each anhydroglucose unit of the cellulose molecule has three hydroxyl groups, the maximum value for DS is three. Preparation Ethyl cellulose is prepared by reacting cellulose with caustic to form caustic cellulose, which is then reacted with chloroethane to form ethyl cellulose. Plasticgrade material contains 44-48% ethoxyl. Although not as resistant as cellulose esters to acids, it is much more resistant to bases. An outstanding feature is its toughness at low temperatures. Brand name Aquacoat ECD (FMC);Ethocel (Dow Chemical). Pharmaceutical Applications Ethylcellulose is widely used in oral and topical pharmaceutical formulations. The main use of ethylcellulose in oral formulations is as a hydrophobic coating agent for tablets and granules.Ethylcellulose coatings are used to modify the release of a drug, to mask an unpleasant taste, or to improve the stability of a formulation; for example, where granules are coated with ethylcellulose to inhibit oxidation. Modified-release tablet formulations may also be produced using ethylcellulose as a matrix former. Ethylcellulose, dissolved in an organic solvent or solvent mixture, can be used on its own to produce water-insoluble films. Higher-viscosity ethylcellulose grades tend to produce stronger and more durable films. Ethylcellulose films may be modified to alter their solubility, by the addition of hypromellose or a plasticizer. An aqueous polymer dispersion (or latex) of ethylcellulose such as Aquacoat ECD (FMC Biopolymer) or Surelease (Colorcon) may also be used to produce ethylcellulose films without the need for organic solvents. Drug release through ethylcellulose-coated dosage forms can be controlled by diffusion through the film coating. This can be a slow process unless a large surface area (e.g. pellets or granules compared with tablets) is utilized. In those instances, aqueous ethylcellulose dispersions are generally used to coat granules or pellets. Ethylcellulose-coated beads and granules have also demonstrated the ability to absorb pressure and hence protect the coating from fracture during compression. High-viscosity grades of ethylcellulose are used in drug microencapsulation. Release of a drug from an ethylcellulose microcapsule is a function of the microcapsule wall thickness and surface area. In tablet formulations, ethylcellulose may additionally be employed as a binder, the ethylcellulose being blended dry or wetgranulated with a solvent such as ethanol (95%). Ethylcellulose produces hard tablets with low friability, although they may demonstrate poor dissolution. Ethylcellulose has also been used as an agent for delivering therapeutic agents from oral (e.g. dental) appliances. In topical formulations, ethylcellulose is used as a thickening agent in creams, lotions, or gels, provided an appropriate solvent is used. Ethylcellulose has been studied as a stabilizer for emulsions. Ethylcellulose is additionally used in cosmetics and food products. Safety Profile Low toxicity by ingestion and skin contact. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes Safety Ethylcellulose is widely used in oral and topical pharmaceutical formulations. It is also used in food products. Ethylcellulose is not metabolized following oral consumption and is therefore a noncalorific substance. Because ethylcellulose is not metabolized it is not recommended for parenteral products; parenteral use may be harmful to the kidneys. Ethylcellulose is generally regarded as a nontoxic, nonallergenic, and nonirritating material. As ethylcellulose is not considered to be a health hazard, the WHO has not specified an acceptable daily intake. The highest reported level used in an oral product is 308.8 mg in an oral sustained release tablet. LD50 (rabbit, skin): >5 g/kg LD50 (rat, oral): >5 g/kg storage Ethylcellulose is a stable, slightly hygroscopic material. It is chemically resistant to alkalis, both dilute and concentrated, and to salt solutions, although it is more sensitive to acidic materials than are cellulose esters. Ethylcellulose is subject to oxidative degradation in the presence of sunlight or UV light at elevated temperatures. This may be prevented by the use of antioxidant and chemical additives that absorb light in the 230–340nm range. Ethylcellulose should be stored at a temperature not exceeding 32°C (90°F) in a dry area away from all sources of heat. It should not be stored next to peroxides or other oxidizing agents. Incompatibilities Incompatible with paraffin wax and microcrystalline wax. Regulatory Status GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules, suspensions and tablets; topical emulsions and vaginal preparations). Included in nonparenteral medicines licensed in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.   Ethyl cellulose Preparation Products And Raw materials Raw materials CHLOROETHANE-->Dehydrolyzing agent-->Microcrystalline cellulose Preparation Products Carbendazim-->PENTYL ETHER-->scavenger of fabric maculae