China Biggest Manufacturer factory sales Methyl nicotinate CAS 93-60-7 CAS NO.93-60-7

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Methyl nicotinate Basic information Product Name: Methyl nicotinate Synonyms: RARECHEM AL BF 0185;PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER;PELLAGRA PREVENTIVE FACTOR METHYL ESTER;NICONACID METHYL ESTER;NICOTINIC ACID METHYL ESTER;NIACIN METHYL ESTER;METHYL NICOTINATE DAC;METHYL PYRIDINE-3-CARBOXYLATE CAS: 93-60-7 MF: C7H7NO2 MW: 137.14 EINECS: 202-261-8 Product Categories: Pharmaceutical Intermediates;Heterocyclic Compounds Mol File: 93-60-7.mol   Methyl nicotinate Chemical Properties Melting point  42-44 °C (lit.) Boiling point  204 °C (lit.) density  1.2528 (rough estimate) vapor pressure  0.4 hPa (25 °C) FEMA  3709 | METHYL NICOTINATE refractive index  1.5323 (estimate) Fp  204 °F storage temp.  Store below +30°C. solubility  H2O: 0.1 g/mL, clear pka pKa 3.1 (Uncertain) form  Crystals or Crystalline Powder color  White to brownish Water Solubility  NEGLIGIBLE JECFA Number 1320 Merck  14,6100 BRN  113951 InChIKey YNBADRVTZLEFNH-UHFFFAOYSA-N CAS DataBase Reference 93-60-7(CAS DataBase Reference) NIST Chemistry Reference Methyl nicotinate(93-60-7) EPA Substance Registry System Methyl nicotinate (93-60-7)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38-36/38 Safety Statements  26-36-37/39 WGK Germany  3 RTECS  QT1925000 TSCA  Yes HS Code  29333999 Toxicity LD50 orally in Rabbit: > 2000 mg/kg MSDS Information Provider Language Methyl nicotinate English ACROS English SigmaAldrich English ALFA English   Methyl nicotinate Usage And Synthesis Description Methyl nicotinate is a skin irritant in man, in particular producing vasodilatation, which is used on purpose in “rubefacient”, to produce a redness or inflammation for a short period of time, often in lip plumper or other lip products. Methyl nicotinate is also an active ingredient of a number of veterinary preparations intended for topical application as a rubefacient for the treatment of a variety of diseases, such as respiratory diseases, vascular disorders (oedema, haematoma), and rheumatoid disorders in cattle and horses (doses not stated; the concentration in the formulated veterinary medicinal product is 2%). Chemical Properties Methyl nicotinate is white to brownish crystals or crystalline powder and has a fresh, caramellic, nutty and mild tobacco odor. Occurrence Reported found in ground coffee, roasted filberts, guanabana (Annona muicata L.), roasted peanuts, wild strawberries, vanilla bean, papaya, guava, plum, beer cognac, soursop, malt, wort, Bourbon vanilla and mountain papaya. Uses Methyl nicotinate (MN) is the methyl ester of nicotinic acid that is used as an active ingredient, a rubefacient and counter-irritant in over-the-counter topical preparations indicated for the temporary relief of aches and pains in muscles,tendons, and joints. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation.For veterinary purposes，methyl nicotinate is used to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and muscle and joint pains.Methyl nicotinate can be found in in guava fruit, papaya, strawberry, soursop(Annona muricata), beer, grape brandy, coffee, roasted filbert, roasted peanut and Bourbon vanilla. Definition ChEBI: Methyl nicotinate is a member of pyridines and an aromatic carboxylic acid. Application Methyl nicotinate can be employed as a precursor in the synthesis: Di-3-pyridyl ketone ligand, which is used in the preparation of silver(I) complexes for the derivation of coordination polymeric chains. 5-arylnicotinates , ±-sesbanine , and 1,4-dihydropyridine derivatives. Preparation Methyl nicotinate was prepared by esterification of nicotinic acid by refluxing with methanol in the presence of concentrated sulphuric acid, esterification product obtained was extracted into organic solvent (chloroform) after neutralization of the reaction mixture with 10% sodium bicarbonate. Synthesis and antinociceptive activity of methyl nicotinate DOI:10.4314/jpb.v12i1.8 General Description Methyl nicotinate (or nicotinic acid methyl ester) is used as a rubefacient for the relief of pains in muscles, tendons, and joints. It is also used in food as a flavoring agent. Side effects There is presently no side effect information available for Methyl nicotinate(MN) itself. a few patients who applied a medicated topical preparation containing MN (and other components) suffered adverse reactions including faintness, nausea, pain and skin rashes. Safety No data are available for chronic toxicity of Methyl nicotinate(MN) in humans. No adverse effects were reported for nicotinamide in clinical studies, whereas high doses of NA (3000 mg/day) are associated with considerable toxicity. In one third to one half of the 1119 patients taking 3000 mg NA /day for at least five years (to reduce the incidence of a second myocardial infarction), side effects included gastrointestinal and urinary tract problems, as well as dermatological problems of flushing, itching and rash ("The Coronary Drug Project", 1975, cited in "monograph of methyl nicotinate", Council of Europe, 2008, pp. 248). Carcinogenicity No data on the mutagenic or carcinogenic potential of methyl nicotinate were presented. However life-time studies in mice employing doses of 2 to 3 mg nicotinamide/kg bw/day gave no indication of carcinogenic potential.   Methyl nicotinate Preparation Products And Raw materials Preparation Products 3-(1,3,4-OXADIAZOL-2-YL)PYRIDINE-->Nicorandil-->NICOTINIC ACID HYDRAZIDE-->Methyl nicotinoylacetate-->N-Benzylniacin Tag:Methyl nicotinate(93-60-7) Related Product Information

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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Methyl nicotinate Basic information Product Name: Methyl nicotinate Synonyms: RARECHEM AL BF 0185;PYRIDINE-3-CARBOXYLIC ACID METHYL ESTER;PELLAGRA PREVENTIVE FACTOR METHYL ESTER;NICONACID METHYL ESTER;NICOTINIC ACID METHYL ESTER;NIACIN METHYL ESTER;METHYL NICOTINATE DAC;METHYL PYRIDINE-3-CARBOXYLATE CAS: 93-60-7 MF: C7H7NO2 MW: 137.14 EINECS: 202-261-8 Product Categories: Pharmaceutical Intermediates;Heterocyclic Compounds Mol File: 93-60-7.mol   Methyl nicotinate Chemical Properties Melting point  42-44 °C (lit.) Boiling point  204 °C (lit.) density  1.2528 (rough estimate) vapor pressure  0.4 hPa (25 °C) FEMA  3709 | METHYL NICOTINATE refractive index  1.5323 (estimate) Fp  204 °F storage temp.  Store below +30°C. solubility  H2O: 0.1 g/mL, clear pka pKa 3.1 (Uncertain) form  Crystals or Crystalline Powder color  White to brownish Water Solubility  NEGLIGIBLE JECFA Number 1320 Merck  14,6100 BRN  113951 InChIKey YNBADRVTZLEFNH-UHFFFAOYSA-N CAS DataBase Reference 93-60-7(CAS DataBase Reference) NIST Chemistry Reference Methyl nicotinate(93-60-7) EPA Substance Registry System Methyl nicotinate (93-60-7)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38-36/38 Safety Statements  26-36-37/39 WGK Germany  3 RTECS  QT1925000 TSCA  Yes HS Code  29333999 Toxicity LD50 orally in Rabbit: > 2000 mg/kg MSDS Information Provider Language Methyl nicotinate English ACROS English SigmaAldrich English ALFA English   Methyl nicotinate Usage And Synthesis Description Methyl nicotinate is a skin irritant in man, in particular producing vasodilatation, which is used on purpose in “rubefacient”, to produce a redness or inflammation for a short period of time, often in lip plumper or other lip products. Methyl nicotinate is also an active ingredient of a number of veterinary preparations intended for topical application as a rubefacient for the treatment of a variety of diseases, such as respiratory diseases, vascular disorders (oedema, haematoma), and rheumatoid disorders in cattle and horses (doses not stated; the concentration in the formulated veterinary medicinal product is 2%). Chemical Properties Methyl nicotinate is white to brownish crystals or crystalline powder and has a fresh, caramellic, nutty and mild tobacco odor. Occurrence Reported found in ground coffee, roasted filberts, guanabana (Annona muicata L.), roasted peanuts, wild strawberries, vanilla bean, papaya, guava, plum, beer cognac, soursop, malt, wort, Bourbon vanilla and mountain papaya. Uses Methyl nicotinate (MN) is the methyl ester of nicotinic acid that is used as an active ingredient, a rubefacient and counter-irritant in over-the-counter topical preparations indicated for the temporary relief of aches and pains in muscles,tendons, and joints. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation.For veterinary purposes，methyl nicotinate is used to treat respiratory diseases, vascular disorders, rheumatoid arthritis, and muscle and joint pains.Methyl nicotinate can be found in in guava fruit, papaya, strawberry, soursop(Annona muricata), beer, grape brandy, coffee, roasted filbert, roasted peanut and Bourbon vanilla. Definition ChEBI: Methyl nicotinate is a member of pyridines and an aromatic carboxylic acid. Application Methyl nicotinate can be employed as a precursor in the synthesis: Di-3-pyridyl ketone ligand, which is used in the preparation of silver(I) complexes for the derivation of coordination polymeric chains. 5-arylnicotinates , ±-sesbanine , and 1,4-dihydropyridine derivatives. Preparation Methyl nicotinate was prepared by esterification of nicotinic acid by refluxing with methanol in the presence of concentrated sulphuric acid, esterification product obtained was extracted into organic solvent (chloroform) after neutralization of the reaction mixture with 10% sodium bicarbonate. Synthesis and antinociceptive activity of methyl nicotinate DOI:10.4314/jpb.v12i1.8 General Description Methyl nicotinate (or nicotinic acid methyl ester) is used as a rubefacient for the relief of pains in muscles, tendons, and joints. It is also used in food as a flavoring agent. Side effects There is presently no side effect information available for Methyl nicotinate(MN) itself. a few patients who applied a medicated topical preparation containing MN (and other components) suffered adverse reactions including faintness, nausea, pain and skin rashes. Safety No data are available for chronic toxicity of Methyl nicotinate(MN) in humans. No adverse effects were reported for nicotinamide in clinical studies, whereas high doses of NA (3000 mg/day) are associated with considerable toxicity. In one third to one half of the 1119 patients taking 3000 mg NA /day for at least five years (to reduce the incidence of a second myocardial infarction), side effects included gastrointestinal and urinary tract problems, as well as dermatological problems of flushing, itching and rash ("The Coronary Drug Project", 1975, cited in "monograph of methyl nicotinate", Council of Europe, 2008, pp. 248). Carcinogenicity No data on the mutagenic or carcinogenic potential of methyl nicotinate were presented. However life-time studies in mice employing doses of 2 to 3 mg nicotinamide/kg bw/day gave no indication of carcinogenic potential.   Methyl nicotinate Preparation Products And Raw materials Preparation Products 3-(1,3,4-OXADIAZOL-2-YL)PYRIDINE-->Nicorandil-->NICOTINIC ACID HYDRAZIDE-->Methyl nicotinoylacetate-->N-Benzylniacin Tag:Methyl nicotinate(93-60-7) Related Product Information