China Biggest Manufacturer factory sales 2-AminothiazoleCAS 96-50-4 CAS NO.96-50-4

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2-Aminothiazole Basic information Product Name: 2-Aminothiazole Synonyms: 1,3-Thiazol-2-amine;2-Amino-1,3-thiazole;2-AMINO THIOZOLE (96-50-4);2-Aminothiazole sky;2-Aminothiazole 2921;2-Amino-1,3-thiazole 99%;2-thiazole amine;BASEDOL CAS: 96-50-4 MF: C3H4N2S MW: 100.14 EINECS: 202-511-6 Product Categories: 2-Aminothiazole sky;amine;Sulphur Derivatives;Thiazoles;ABADOLE Mol File: 96-50-4.mol   2-Aminothiazole Chemical Properties Melting point  91-93 °C (lit.) Boiling point  117 °C (15.002 mmHg) density  1.241 (estimate) vapor pressure  <1 hPa (20 °C) refractive index  1.5300 (estimate) Fp  117°C/15mm storage temp.  Store below +30°C. solubility  1 M HCl: soluble50mg/mL, clear (dark yellow-brown) pka 5.36(at 20℃) form  Crystalline Powder, Grains, Lumps or Flakes color  Brown PH 9.6 (100g/l, H2O, 20℃) Water Solubility  100 g/L (20 ºC) Merck  14,479 BRN  105738 InChIKey RAIPHJJURHTUIC-UHFFFAOYSA-N CAS DataBase Reference 96-50-4(CAS DataBase Reference) NIST Chemistry Reference 2-Aminothiazole(96-50-4) EPA Substance Registry System 2-Aminothiazole (96-50-4)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36-36/37-20/21/22 Safety Statements  26-36/37-39-36 WGK Germany  3 RTECS  XJ2100000 F  8-9 Autoignition Temperature 600 °C Hazard Note  Irritant TSCA  Yes HS Code  29341000 Toxicity LD50 orally in Rabbit: 480 mg/kg MSDS Information Provider Language 2-Aminothiazole English ACROS English SigmaAldrich English ALFA English   2-Aminothiazole Usage And Synthesis Chemical Properties brown crystalline powder, grains, lumps or flakes Uses antithyroid agent Uses 2-Aminothiazole is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds. Uses Usually used in the synthesis of 2-aminothiazole-modified silica gel，and aslo used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation. Definition ChEBI: A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2. Synthesis Reference(s) Journal of the American Chemical Society, 76, p. 693, 1954 DOI: 10.1021/ja01632a016 General Description Light brown crystals or brown granular solid. Air & Water Reactions Insoluble in water. Reactivity Profile 2-Aminothiazole reacts violently when nitrated with nitric or nitric-sulfuric acids. 2-Aminothiazole is also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. Fire Hazard Flash point data for 2-Aminothiazole are not available; however, 2-Aminothiazole is probably combustible. Biochem/physiol Actions 2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders. Safety Profile Poison by ingestion andintraperitoneal routes. Mutation data reported.Spontaneous ignition occurs at 100°. Mixtures with nitricacid or nitric acid + sulfuric acid explode on heating.Incompatible with HNO3 and H2SO4. When heated todecomposition it emi Purification Methods It crystallises from pet ether (b 100-120o), or EtOH. [Beilstein 27 III/IV 4574.]   2-Aminothiazole Preparation Products And Raw materials Raw materials Thiourea-->Chloroacetaldehyde Preparation Products ethyl 2-(2-aminothiazol-5-ylthio)acetate-->BASIC RED 29-->2-Amino-5-nitrothiazole-->2-Amino-((1-carboxy-1-methyl ethoxy)imino)-4-thiazoleacetic acid-->3-(-Hydroxyphenethyl)-2-imino thiazolidine-->2-Amino-5-bromothiazole monohydrobromide-->2-CHLORO-5-NITROTHIAZOLE-->1,3-Thiazole-2-carbaldehyde-->Cationic Violet 3BL-->2-Amino-5-bromothiazole-->Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid-->Nitazoxanide Impurity-->Oxazole-2-amine

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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2-Aminothiazole Basic information Product Name: 2-Aminothiazole Synonyms: 1,3-Thiazol-2-amine;2-Amino-1,3-thiazole;2-AMINO THIOZOLE (96-50-4);2-Aminothiazole sky;2-Aminothiazole 2921;2-Amino-1,3-thiazole 99%;2-thiazole amine;BASEDOL CAS: 96-50-4 MF: C3H4N2S MW: 100.14 EINECS: 202-511-6 Product Categories: 2-Aminothiazole sky;amine;Sulphur Derivatives;Thiazoles;ABADOLE Mol File: 96-50-4.mol   2-Aminothiazole Chemical Properties Melting point  91-93 °C (lit.) Boiling point  117 °C (15.002 mmHg) density  1.241 (estimate) vapor pressure  <1 hPa (20 °C) refractive index  1.5300 (estimate) Fp  117°C/15mm storage temp.  Store below +30°C. solubility  1 M HCl: soluble50mg/mL, clear (dark yellow-brown) pka 5.36(at 20℃) form  Crystalline Powder, Grains, Lumps or Flakes color  Brown PH 9.6 (100g/l, H2O, 20℃) Water Solubility  100 g/L (20 ºC) Merck  14,479 BRN  105738 InChIKey RAIPHJJURHTUIC-UHFFFAOYSA-N CAS DataBase Reference 96-50-4(CAS DataBase Reference) NIST Chemistry Reference 2-Aminothiazole(96-50-4) EPA Substance Registry System 2-Aminothiazole (96-50-4)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36-36/37-20/21/22 Safety Statements  26-36/37-39-36 WGK Germany  3 RTECS  XJ2100000 F  8-9 Autoignition Temperature 600 °C Hazard Note  Irritant TSCA  Yes HS Code  29341000 Toxicity LD50 orally in Rabbit: 480 mg/kg MSDS Information Provider Language 2-Aminothiazole English ACROS English SigmaAldrich English ALFA English   2-Aminothiazole Usage And Synthesis Chemical Properties brown crystalline powder, grains, lumps or flakes Uses antithyroid agent Uses 2-Aminothiazole is a heterocyclic amine and is the beginning reagent for the synthesis of many pharmaceutical and agricultural related compounds. Uses Usually used in the synthesis of 2-aminothiazole-modified silica gel，and aslo used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation. Definition ChEBI: A primary amino compound that is 1,3-thiazole substituted by an amino group at position 2. Synthesis Reference(s) Journal of the American Chemical Society, 76, p. 693, 1954 DOI: 10.1021/ja01632a016 General Description Light brown crystals or brown granular solid. Air & Water Reactions Insoluble in water. Reactivity Profile 2-Aminothiazole reacts violently when nitrated with nitric or nitric-sulfuric acids. 2-Aminothiazole is also incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides. Fire Hazard Flash point data for 2-Aminothiazole are not available; however, 2-Aminothiazole is probably combustible. Biochem/physiol Actions 2-Aminothiazoles are potent cyclin-dependent kinase 5 inhibitors and are therapeutic agents for the treatment of Alzheimer′s disease and other neurodegenerative disorders. Safety Profile Poison by ingestion andintraperitoneal routes. Mutation data reported.Spontaneous ignition occurs at 100°. Mixtures with nitricacid or nitric acid + sulfuric acid explode on heating.Incompatible with HNO3 and H2SO4. When heated todecomposition it emi Purification Methods It crystallises from pet ether (b 100-120o), or EtOH. [Beilstein 27 III/IV 4574.]   2-Aminothiazole Preparation Products And Raw materials Raw materials Thiourea-->Chloroacetaldehyde Preparation Products ethyl 2-(2-aminothiazol-5-ylthio)acetate-->BASIC RED 29-->2-Amino-5-nitrothiazole-->2-Amino-((1-carboxy-1-methyl ethoxy)imino)-4-thiazoleacetic acid-->3-(-Hydroxyphenethyl)-2-imino thiazolidine-->2-Amino-5-bromothiazole monohydrobromide-->2-CHLORO-5-NITROTHIAZOLE-->1,3-Thiazole-2-carbaldehyde-->Cationic Violet 3BL-->2-Amino-5-bromothiazole-->Imidazo[2,1-b][1,3]thiazole-6-carboxylic acid-->Nitazoxanide Impurity-->Oxazole-2-amine