China Biggest Manufacturer factory supply L-MALIC ACID CAS 97-67-6 CAS NO.97-67-6

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L-(-)-Malic Acid Basic information Product Name: L-(-)-Malic Acid Synonyms: L-(-)-Malic acid, CP;Butanedioic acid, 2-hydroxy-, (2S)-;pinguosuan;Butanedioicacid,hydroxy-,(S)-;hydroxy-,(S)-Butanedioicacid;l-(ii)-malicacid;L-Gydroxybutanedioicacid;L-Mailcacid CAS: 97-67-6 MF: C4H6O5 MW: 134.09 EINECS: 202-601-5 Product Categories: Plant extracts;Aliphatics;MalicAcidSeries;Carboxylic Acids (Chiral);Chiral chemicals;Chiral Reagents;Food & Feed ADDITIVES;Chiral Building Blocks;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;Food additive and acidulant;Imidazoles ,Heterocyclic Acids Mol File: 97-67-6.mol   L-(-)-Malic Acid Chemical Properties Melting point  101-103 °C (lit.) alpha  -2 º (c=8.5, H2O) Boiling point  167.16°C (rough estimate) density  1.60 FEMA  2655 | L-MALIC ACID refractive index  -6.5 ° (C=10, Acetone) Fp  220 °C storage temp.  Store below +30°C. solubility  H2O: 0.5 M at 20 °C, clear, colorless form  Powder color  White Specific Gravity 1.595 (20/4℃) PH 2.2 (10g/l, H2O, 20℃) pka (1) 3.46, (2) 5.10(at 25℃) optical activity [α]20/D 30±2°, c = 5.5% in pyridine Water Solubility  soluble Merck  14,5707 JECFA Number 619 BRN  1723541 InChIKey BJEPYKJPYRNKOW-REOHCLBHSA-N CAS DataBase Reference 97-67-6(CAS DataBase Reference) NIST Chemistry Reference Butanedioic acid, hydroxy-, (s)-(97-67-6) EPA Substance Registry System Butanedioic acid, 2-hydroxy-, (2S)- (97-67-6)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-37/39 WGK Germany  3 RTECS  ON7175000 TSCA  Yes HS Code  29181980 MSDS Information Provider Language L(-)-Malic acid English ACROS English SigmaAldrich English ALFA English   L-(-)-Malic Acid Usage And Synthesis Description ι-Malic acid is nearly odorless (sometimes a faint, acrid odor) with a tart, acidic taste. It is nonpungent. May be prepared by hydration of maleic acid; by fermentation from sugars. Chemical Properties L-Malic acid is nearly odorless (sometimes a faint, acrid odor). This compound has a tart, acidic, nonpungent taste. Chemical Properties clear colourless solution Occurrence Occurs in maple sap, apple, melon, papaya, beer, grape wine, cocoa, sake, kiwifruit and chicory root. Uses L-(-)-Malic acid is used as a food additive, Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, and phoslactomycin B. Uses The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid rece Uses Intermediate in chemical synthesis. Chelating and buffering agent. Flavoring agent, flavor enhancer and acidulant in foods. Definition ChEBI: An optically active form of malic acid having (S)-configuration. Preparation By hydration of maleic acid; by fermentation from sugars. General Description L-(-)-Malic acid is an organic acid that is commonly found in wine. It plays an important role in wine microbiological stability. Biochem/physiol Actions Malic acid is a part of cellular metabolism. Its application is recognized in pharmaceutics. It is useful in the treatment of hepatic malfunctioning, effective against hyper-ammonemia. It is used as a part of amino acid infusion. Malic acid also serves as a nanomedicine in the treatment of brain neurological disorders. A TCA (Krebs cycle) intermediate and partner in the malic acid aspartate shuttle. Purification Methods Crystallise S-malic acid (charcoal) from ethyl acetate/pet ether (b 55-56o), keeping the temperature below 65o. Or dissolve it by refluxing in fifteen parts of anhydrous diethyl ether, decant, concentrate to one-third volume and crystallise it at 0o, repeatedly to constant melting point. [Beilstein 3 IV 1123.]   L-(-)-Malic Acid Preparation Products And Raw materials Raw materials Calcium carbonate-->Poly(acrylic acid)-->(2S)-1-(3-Acetylthio-2-methyl-1-oxopropyl)-L-proline-->Disodium fumarate Preparation Products (R)-(-)-3-Quinuclidinol-->(S)-3-Hydroxypyrrolidine hydrochloride-->(S)-1-Benzyl-3-pyrrolidinol-->(-)-(1S,4R)-4-AMINOCYCLOPENT-2-ENECARBOXYLIC ACID-->(R)-3-Quinuclidinol hydrochloride-->(S)-(+)-3-Hydroxytetrahydrofuran-->Fluorescent Brightener 135-->Diethyl malate-->Coumalic acid-->CHLOROSUCCINIC ACID

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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L-(-)-Malic Acid Basic information Product Name: L-(-)-Malic Acid Synonyms: L-(-)-Malic acid, CP;Butanedioic acid, 2-hydroxy-, (2S)-;pinguosuan;Butanedioicacid,hydroxy-,(S)-;hydroxy-,(S)-Butanedioicacid;l-(ii)-malicacid;L-Gydroxybutanedioicacid;L-Mailcacid CAS: 97-67-6 MF: C4H6O5 MW: 134.09 EINECS: 202-601-5 Product Categories: Plant extracts;Aliphatics;MalicAcidSeries;Carboxylic Acids (Chiral);Chiral chemicals;Chiral Reagents;Food & Feed ADDITIVES;Chiral Building Blocks;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;Food additive and acidulant;Imidazoles ,Heterocyclic Acids Mol File: 97-67-6.mol   L-(-)-Malic Acid Chemical Properties Melting point  101-103 °C (lit.) alpha  -2 º (c=8.5, H2O) Boiling point  167.16°C (rough estimate) density  1.60 FEMA  2655 | L-MALIC ACID refractive index  -6.5 ° (C=10, Acetone) Fp  220 °C storage temp.  Store below +30°C. solubility  H2O: 0.5 M at 20 °C, clear, colorless form  Powder color  White Specific Gravity 1.595 (20/4℃) PH 2.2 (10g/l, H2O, 20℃) pka (1) 3.46, (2) 5.10(at 25℃) optical activity [α]20/D 30±2°, c = 5.5% in pyridine Water Solubility  soluble Merck  14,5707 JECFA Number 619 BRN  1723541 InChIKey BJEPYKJPYRNKOW-REOHCLBHSA-N CAS DataBase Reference 97-67-6(CAS DataBase Reference) NIST Chemistry Reference Butanedioic acid, hydroxy-, (s)-(97-67-6) EPA Substance Registry System Butanedioic acid, 2-hydroxy-, (2S)- (97-67-6)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-37/39 WGK Germany  3 RTECS  ON7175000 TSCA  Yes HS Code  29181980 MSDS Information Provider Language L(-)-Malic acid English ACROS English SigmaAldrich English ALFA English   L-(-)-Malic Acid Usage And Synthesis Description ι-Malic acid is nearly odorless (sometimes a faint, acrid odor) with a tart, acidic taste. It is nonpungent. May be prepared by hydration of maleic acid; by fermentation from sugars. Chemical Properties L-Malic acid is nearly odorless (sometimes a faint, acrid odor). This compound has a tart, acidic, nonpungent taste. Chemical Properties clear colourless solution Occurrence Occurs in maple sap, apple, melon, papaya, beer, grape wine, cocoa, sake, kiwifruit and chicory root. Uses L-(-)-Malic acid is used as a food additive, Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, and phoslactomycin B. Uses The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid rece Uses Intermediate in chemical synthesis. Chelating and buffering agent. Flavoring agent, flavor enhancer and acidulant in foods. Definition ChEBI: An optically active form of malic acid having (S)-configuration. Preparation By hydration of maleic acid; by fermentation from sugars. General Description L-(-)-Malic acid is an organic acid that is commonly found in wine. It plays an important role in wine microbiological stability. Biochem/physiol Actions Malic acid is a part of cellular metabolism. Its application is recognized in pharmaceutics. It is useful in the treatment of hepatic malfunctioning, effective against hyper-ammonemia. It is used as a part of amino acid infusion. Malic acid also serves as a nanomedicine in the treatment of brain neurological disorders. A TCA (Krebs cycle) intermediate and partner in the malic acid aspartate shuttle. Purification Methods Crystallise S-malic acid (charcoal) from ethyl acetate/pet ether (b 55-56o), keeping the temperature below 65o. Or dissolve it by refluxing in fifteen parts of anhydrous diethyl ether, decant, concentrate to one-third volume and crystallise it at 0o, repeatedly to constant melting point. [Beilstein 3 IV 1123.]   L-(-)-Malic Acid Preparation Products And Raw materials Raw materials Calcium carbonate-->Poly(acrylic acid)-->(2S)-1-(3-Acetylthio-2-methyl-1-oxopropyl)-L-proline-->Disodium fumarate Preparation Products (R)-(-)-3-Quinuclidinol-->(S)-3-Hydroxypyrrolidine hydrochloride-->(S)-1-Benzyl-3-pyrrolidinol-->(-)-(1S,4R)-4-AMINOCYCLOPENT-2-ENECARBOXYLIC ACID-->(R)-3-Quinuclidinol hydrochloride-->(S)-(+)-3-Hydroxytetrahydrofuran-->Fluorescent Brightener 135-->Diethyl malate-->Coumalic acid-->CHLOROSUCCINIC ACID