China Biggest Factory manufacturer supply Citicoline(CDP-Choline) CAS NO.987-78-0

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CYTIDINE 5'-DIPHOSPHOCHOLINE Basic information Product Name: CYTIDINE 5'-DIPHOSPHOCHOLINE Synonyms: CYTIDINE 5'-DIPHOSPH;Cytidine 5'-(trihydrogen diphosphate), P'-[2-(trimethylammonio)ethyl] ester, inner salt;Difosfocin;Emicholine F;Haocolin;Hornbest;Neucolis;NSC 122002 CAS: 987-78-0 MF: C14H26N4O11P2 MW: 488.33 EINECS: 213-580-7 Product Categories: Pharmaceutical Intermediates;ZOLOFT Mol File: 987-78-0.mol   CYTIDINE 5'-DIPHOSPHOCHOLINE Chemical Properties Melting point  >185°C (dec.) alpha  D25 +19.0° (c = 0.86 in H2O) storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C solubility  Water (Sparingly) pka 4.4(at 25℃) form  Solid color  White Stability: Moisture Sensitive CAS DataBase Reference 987-78-0(CAS DataBase Reference)   Safety Information Toxicity LD50 in mice, rats (mg/kg): 4600 ±335, 4150 ±370 i.v.; both species 8 g/kg orally (Grau) MSDS Information   CYTIDINE 5'-DIPHOSPHOCHOLINE Usage And Synthesis Originator Nicholin,Cyanamid,Italy,1971 Uses antidepressant, 5HT uptake inhibitor Manufacturing Process A 250 ml conical flask containing 30 ml of a reaction liquor (pH 7.0) having a composition of 7.38 mg/ml of disodium salt of CMP (cytidine-5'- monophosphate), 24 mg/ml of choline, 10 mg/ml of glucose, 100 mg/ml of acetone-dried cells of Brevibacterium ammoniagenes ATCC 6872, 11.6 mg/ml of monopotassium phosphate, 20 mg/ml of dipotassium phosphate and 2.96 mg/ml of magnesium sulfate, (MgSO4·7H2O), was subjected to culturing at 30°C for 4 hours. Cytidine diphosphate choline was formed and accumulated at a concentration of 3.8 mg/ml in the culture liquor. The pH of 1.2 liters of filtrate containing 3.8 mg/ml of cytidine diphosphate choline, obtained by removing solid matters from the culturing liquor, was adjusted to a pH of 8.5 with a 0.5 N KOH solution. The filtrate was passed through a column of strongly basic anion exchange resin, Dowex 1 x 2 (formic acid type). After washing the resin with water, a formic acid solution was passed through the column with gradual increase in the concentration of formic acid (until 0.04 N max.). A fraction of cytidine diphosphate choline was collected by elution according to the so-called gradient elution method and absorbed onto carbon powders. Then, elution was effected with acetone, and the eluate was concentrated and dried. 1.3 g of cytidine diphosphate choline powders were obtained. Therapeutic Function Cerebral circulation stimulant   CYTIDINE 5'-DIPHOSPHOCHOLINE Preparation Products And Raw materials Raw materials Iodomethane-->Ethyleneimine-->Yeast extract-->Cytosine-->phosphorylcholine-->Cytidine 5’-monophosphate-->CHOLINE-->Brevibacterium ammoniagenes-->Cytidine, 5'-(hydrogen 4-morpholinylphosphonate)-->Calcium phosphorylcholine chloride-->Choline chloride-->DEXTROSE-->Orotic acid

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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CYTIDINE 5'-DIPHOSPHOCHOLINE Basic information Product Name: CYTIDINE 5'-DIPHOSPHOCHOLINE Synonyms: CYTIDINE 5'-DIPHOSPH;Cytidine 5'-(trihydrogen diphosphate), P'-[2-(trimethylammonio)ethyl] ester, inner salt;Difosfocin;Emicholine F;Haocolin;Hornbest;Neucolis;NSC 122002 CAS: 987-78-0 MF: C14H26N4O11P2 MW: 488.33 EINECS: 213-580-7 Product Categories: Pharmaceutical Intermediates;ZOLOFT Mol File: 987-78-0.mol   CYTIDINE 5'-DIPHOSPHOCHOLINE Chemical Properties Melting point  >185°C (dec.) alpha  D25 +19.0° (c = 0.86 in H2O) storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C solubility  Water (Sparingly) pka 4.4(at 25℃) form  Solid color  White Stability: Moisture Sensitive CAS DataBase Reference 987-78-0(CAS DataBase Reference)   Safety Information Toxicity LD50 in mice, rats (mg/kg): 4600 ±335, 4150 ±370 i.v.; both species 8 g/kg orally (Grau) MSDS Information   CYTIDINE 5'-DIPHOSPHOCHOLINE Usage And Synthesis Originator Nicholin,Cyanamid,Italy,1971 Uses antidepressant, 5HT uptake inhibitor Manufacturing Process A 250 ml conical flask containing 30 ml of a reaction liquor (pH 7.0) having a composition of 7.38 mg/ml of disodium salt of CMP (cytidine-5'- monophosphate), 24 mg/ml of choline, 10 mg/ml of glucose, 100 mg/ml of acetone-dried cells of Brevibacterium ammoniagenes ATCC 6872, 11.6 mg/ml of monopotassium phosphate, 20 mg/ml of dipotassium phosphate and 2.96 mg/ml of magnesium sulfate, (MgSO4·7H2O), was subjected to culturing at 30°C for 4 hours. Cytidine diphosphate choline was formed and accumulated at a concentration of 3.8 mg/ml in the culture liquor. The pH of 1.2 liters of filtrate containing 3.8 mg/ml of cytidine diphosphate choline, obtained by removing solid matters from the culturing liquor, was adjusted to a pH of 8.5 with a 0.5 N KOH solution. The filtrate was passed through a column of strongly basic anion exchange resin, Dowex 1 x 2 (formic acid type). After washing the resin with water, a formic acid solution was passed through the column with gradual increase in the concentration of formic acid (until 0.04 N max.). A fraction of cytidine diphosphate choline was collected by elution according to the so-called gradient elution method and absorbed onto carbon powders. Then, elution was effected with acetone, and the eluate was concentrated and dried. 1.3 g of cytidine diphosphate choline powders were obtained. Therapeutic Function Cerebral circulation stimulant   CYTIDINE 5'-DIPHOSPHOCHOLINE Preparation Products And Raw materials Raw materials Iodomethane-->Ethyleneimine-->Yeast extract-->Cytosine-->phosphorylcholine-->Cytidine 5’-monophosphate-->CHOLINE-->Brevibacterium ammoniagenes-->Cytidine, 5'-(hydrogen 4-morpholinylphosphonate)-->Calcium phosphorylcholine chloride-->Choline chloride-->DEXTROSE-->Orotic acid