China Biggest Factory manufacturer supply p-Hydroxyacetophenone CAS NO.99-93-4

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4'-Hydroxyacetophenone Basic information Product Name: 4'-Hydroxyacetophenone Synonyms: 1-(4-hydroxyphenyl)-ethanon;4’-hydroxy-acetophenon;4-Hydroksyacetofenol;Acetophenone, p-hydroxy-;Ethanone, 1-(4-hydroxyphenyl)-;Hydroxyacetophenone, para;HYDROXYACETOPHENONE-4;HYDROXYBENZOPHENONE-4 CAS: 99-93-4 MF: C8H8O2 MW: 136.15 EINECS: 202-802-8 Product Categories: Pyridines;Pharmaceutical intermediates for Choleretic and Salbutamol;Aromatic Acetophenones & Derivatives (substituted);Aromatics;Miscellaneous Reagents;Eczema, medicine and other organic synthesis intermediates;Acetophenone Series;FINE Chemical & INTERMEDIATES;AcetophenoneCarbonyl Compounds;C7 to C8;Ketones;Organic Photoinitiators;Polymerization Initiators;Carbonyl Compounds;VX:15689727968 Mol File: 99-93-4.mol   4'-Hydroxyacetophenone Chemical Properties Melting point  132-135 °C(lit.) Boiling point  147-148 °C3 mm Hg(lit.) density  1.109 FEMA  4330 | 4-HYDROXYACETOPHENONE refractive index  1.5577 (estimate) Fp  166 °C storage temp.  Store below +30°C. solubility  methanol: 0.1 g/mL, clear form  Crystalline Powder pka 8.05(at 25℃) Specific Gravity 1.109 color  Almost white to beige Water Solubility  10 g/L (22 ºC) JECFA Number 2040 BRN  774355 InChIKey TXFPEBPIARQUIG-UHFFFAOYSA-N CAS DataBase Reference 99-93-4(CAS DataBase Reference) NIST Chemistry Reference Acetophenone, 4'-hydroxy-(99-93-4) EPA Substance Registry System 4-Hydroxyacetophenone (99-93-4)   Safety Information Hazard Codes  Xn,Xi Risk Statements  36/37/38-22 Safety Statements  26-36/37-37/39-24/25-22-36 WGK Germany  3 RTECS  PC4959775 Hazard Note  Irritant TSCA  Yes HS Code  29145000 MSDS Information Provider Language 1-(4-Hydroxyphenyl)ethanone English SigmaAldrich English ACROS English ALFA English   4'-Hydroxyacetophenone Usage And Synthesis Chemical Properties almost white to beige crystalline powder Chemical Properties White to beige powder; sweet, hawthorn, balsam, mimosa aroma Occurrence Reported found in cloudberry, coffee, cranberry, mango, sherry, and wort. Uses 4 -Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions. Uses 4′-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions. Uses p-Hydroxyacetophenone is widely used in medicine, cosmetics and industrial fields. It is a natural plant extract, which naturally exists in the stems and leaves of the Compositae plant, Artemisia annua, the roots of plants such as Artemisia annua, Rhododendron, and Panax ginseng. It has a good effect on yellow eyes caused by diseases such as hepatitis, and also has a good auxiliary effect on yellow eyes caused by various reasons. Due to its weak molecular activity, high temperature resistance, melting point of 95-97 °C and boiling point of 296 °C, it is widely used in various liquid pharmaceuticals and can prolong the shelf life of other active ingredients under high temperature conditions. It has no harm to human skin and is the safest high-temperature auxiliary active stabilizer in the pharmaceutical industry. Preparation Preparation by Fries rearrangement of phenyl acetate with Lewis acids aluminium chloride in nitrobenzene at 20–25° or at 50–60° in chlorobenzene between 45° and 65°, sealed tube and subjected to high power microwave irradiation for 2 min only (36%) in nitroethane at 60° (44%) in carbon disulfide at 45° (40%) in petroleum ether at 50° (20%) but between 130° and 175° (40–60%) aluminium chloride–sodium chloride mixture at 240–250° (10%) boron trifluoride at 90° (56%) scandium tris(trifluoromethanesulfonate), in nitromethane, at 50° (39%) titanium tetrachloride at 90–100° (34%) ferric chloride at 65° (25%) zinc chloride at 125° (8%) hydrofluoric acid, between 20° and 100° (94%) polyphosphoric acid, between 20° and 100° (69%) (50–53%)(44%) Nafion-XR 500, sulfonic acid type at 100° ZSM-5, in sulfolane, at 180° (28%) H-ZSM-5 at 400° or at 210° (6%) H-Nu-2 at 170° (15%) HY (Si/Al = 3) or fluorided alumina (Al2O3-F; 3 % wt. F), at 400°. Definition ChEBI: A monohydroxyacetophenone carrying a hydroxy substituent at position 4'. Aroma threshold values Floral type, medium strength odor; recommend smelling in a 10.00% solution or less. Synthesis Reference(s) Tetrahedron Letters, 32, p. 5829, 1991 DOI: 10.1016/S0040-4039(00)93567-6 General Description Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards Purification Methods Crystallise it from diethyl ether, aqueous EtOH or *benzene/pet ether. [Beilstein 8 H 87, 8 IV 339.]   4'-Hydroxyacetophenone Preparation Products And Raw materials Raw materials Aluminum chloride-->2'-Hydroxyacetophenone-->4-Aminoacetophenone-->PHENYL ACETATE Preparation Products Acetaminophen-->4-Hydroxystyrene-->4-Acetoxystyrene-->4-Benzyloxy-3-nitroacetophenone-->4-QUINOXALIN-2-YLPHENOL-->HPG-->4-Acetyloxy-3-acetyloxymethyl-(N-benzyl-N-tertbutylamino)acetophenone hydrochloride-->4-Hydroxyphenethyl alcohol-->1-(3-CHLOROMETHYL-4-HYDROXY-PHENYL)-ETHANONE-->1-(4-Acetyloxy)-3-((acetyloxy)methyl)phenyl)-2-bromoethanone-->1,1,1-Tris(4-hydroxyphenyl)ethane-->Atenolol-->Micafungin Side Chain Methyl Ester-->3',5'-DICHLORO-4'-HYDROXYACETOPHENONE-->4-HYDROXYBENZOYLACETIC ACID METHYL ESTER-->4'-PIPERIDINOACETOPHENONE-->2-(4-HYDROXYPHENYL)PROPIONIC ACID

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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4'-Hydroxyacetophenone Basic information Product Name: 4'-Hydroxyacetophenone Synonyms: 1-(4-hydroxyphenyl)-ethanon;4’-hydroxy-acetophenon;4-Hydroksyacetofenol;Acetophenone, p-hydroxy-;Ethanone, 1-(4-hydroxyphenyl)-;Hydroxyacetophenone, para;HYDROXYACETOPHENONE-4;HYDROXYBENZOPHENONE-4 CAS: 99-93-4 MF: C8H8O2 MW: 136.15 EINECS: 202-802-8 Product Categories: Pyridines;Pharmaceutical intermediates for Choleretic and Salbutamol;Aromatic Acetophenones & Derivatives (substituted);Aromatics;Miscellaneous Reagents;Eczema, medicine and other organic synthesis intermediates;Acetophenone Series;FINE Chemical & INTERMEDIATES;AcetophenoneCarbonyl Compounds;C7 to C8;Ketones;Organic Photoinitiators;Polymerization Initiators;Carbonyl Compounds;VX:15689727968 Mol File: 99-93-4.mol   4'-Hydroxyacetophenone Chemical Properties Melting point  132-135 °C(lit.) Boiling point  147-148 °C3 mm Hg(lit.) density  1.109 FEMA  4330 | 4-HYDROXYACETOPHENONE refractive index  1.5577 (estimate) Fp  166 °C storage temp.  Store below +30°C. solubility  methanol: 0.1 g/mL, clear form  Crystalline Powder pka 8.05(at 25℃) Specific Gravity 1.109 color  Almost white to beige Water Solubility  10 g/L (22 ºC) JECFA Number 2040 BRN  774355 InChIKey TXFPEBPIARQUIG-UHFFFAOYSA-N CAS DataBase Reference 99-93-4(CAS DataBase Reference) NIST Chemistry Reference Acetophenone, 4'-hydroxy-(99-93-4) EPA Substance Registry System 4-Hydroxyacetophenone (99-93-4)   Safety Information Hazard Codes  Xn,Xi Risk Statements  36/37/38-22 Safety Statements  26-36/37-37/39-24/25-22-36 WGK Germany  3 RTECS  PC4959775 Hazard Note  Irritant TSCA  Yes HS Code  29145000 MSDS Information Provider Language 1-(4-Hydroxyphenyl)ethanone English SigmaAldrich English ACROS English ALFA English   4'-Hydroxyacetophenone Usage And Synthesis Chemical Properties almost white to beige crystalline powder Chemical Properties White to beige powder; sweet, hawthorn, balsam, mimosa aroma Occurrence Reported found in cloudberry, coffee, cranberry, mango, sherry, and wort. Uses 4 -Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions. Uses 4′-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions. Uses p-Hydroxyacetophenone is widely used in medicine, cosmetics and industrial fields. It is a natural plant extract, which naturally exists in the stems and leaves of the Compositae plant, Artemisia annua, the roots of plants such as Artemisia annua, Rhododendron, and Panax ginseng. It has a good effect on yellow eyes caused by diseases such as hepatitis, and also has a good auxiliary effect on yellow eyes caused by various reasons. Due to its weak molecular activity, high temperature resistance, melting point of 95-97 °C and boiling point of 296 °C, it is widely used in various liquid pharmaceuticals and can prolong the shelf life of other active ingredients under high temperature conditions. It has no harm to human skin and is the safest high-temperature auxiliary active stabilizer in the pharmaceutical industry. Preparation Preparation by Fries rearrangement of phenyl acetate with Lewis acids aluminium chloride in nitrobenzene at 20–25° or at 50–60° in chlorobenzene between 45° and 65°, sealed tube and subjected to high power microwave irradiation for 2 min only (36%) in nitroethane at 60° (44%) in carbon disulfide at 45° (40%) in petroleum ether at 50° (20%) but between 130° and 175° (40–60%) aluminium chloride–sodium chloride mixture at 240–250° (10%) boron trifluoride at 90° (56%) scandium tris(trifluoromethanesulfonate), in nitromethane, at 50° (39%) titanium tetrachloride at 90–100° (34%) ferric chloride at 65° (25%) zinc chloride at 125° (8%) hydrofluoric acid, between 20° and 100° (94%) polyphosphoric acid, between 20° and 100° (69%) (50–53%)(44%) Nafion-XR 500, sulfonic acid type at 100° ZSM-5, in sulfolane, at 180° (28%) H-ZSM-5 at 400° or at 210° (6%) H-Nu-2 at 170° (15%) HY (Si/Al = 3) or fluorided alumina (Al2O3-F; 3 % wt. F), at 400°. Definition ChEBI: A monohydroxyacetophenone carrying a hydroxy substituent at position 4'. Aroma threshold values Floral type, medium strength odor; recommend smelling in a 10.00% solution or less. Synthesis Reference(s) Tetrahedron Letters, 32, p. 5829, 1991 DOI: 10.1016/S0040-4039(00)93567-6 General Description Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards Purification Methods Crystallise it from diethyl ether, aqueous EtOH or *benzene/pet ether. [Beilstein 8 H 87, 8 IV 339.]   4'-Hydroxyacetophenone Preparation Products And Raw materials Raw materials Aluminum chloride-->2'-Hydroxyacetophenone-->4-Aminoacetophenone-->PHENYL ACETATE Preparation Products Acetaminophen-->4-Hydroxystyrene-->4-Acetoxystyrene-->4-Benzyloxy-3-nitroacetophenone-->4-QUINOXALIN-2-YLPHENOL-->HPG-->4-Acetyloxy-3-acetyloxymethyl-(N-benzyl-N-tertbutylamino)acetophenone hydrochloride-->4-Hydroxyphenethyl alcohol-->1-(3-CHLOROMETHYL-4-HYDROXY-PHENYL)-ETHANONE-->1-(4-Acetyloxy)-3-((acetyloxy)methyl)phenyl)-2-bromoethanone-->1,1,1-Tris(4-hydroxyphenyl)ethane-->Atenolol-->Micafungin Side Chain Methyl Ester-->3',5'-DICHLORO-4'-HYDROXYACETOPHENONE-->4-HYDROXYBENZOYLACETIC ACID METHYL ESTER-->4'-PIPERIDINOACETOPHENONE-->2-(4-HYDROXYPHENYL)PROPIONIC ACID