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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

Product information

D-tagatose Basic information Product Name: D-tagatose Synonyms: d-tagatos;TAGATOSE, D-;TAGLOSE;P-TAGATOSE;D-(-)-TAGATOSE;(2S,3S,4S,5R)-2-(hydroxymethyl)oxane-2,3,4,5-tetrol;D-(-)-Tagatose,mixture of anomers;D-lyxo-2-Hexulose CAS: 87-81-0 MF: C6H12O6 MW: 180.16 EINECS: 201-772-3 Product Categories: carbohydrate;Carbohydrates & Derivatives;Basic Sugars (Mono & Oligosaccharides);Biochemistry;Intermediates & Fine Chemicals;Pharmaceuticals;Sugars;Tagatose;Dextrins、Sugar & Carbohydrates;Carbohydrate LibraryCarbohydrates;Carbohydrates;Carbohydrates A to;Carbohydrates P-ZBiochemicals and Reagents;Metabolic Libraries;Metabolomics;Monosaccharide;87-81-0 Mol File: 87-81-0.mol   D-tagatose Chemical Properties Melting point  130-136 °C alpha  D25 -5° (c = 1 in water) Boiling point  232.96°C (rough estimate) density  1.2805 (rough estimate) refractive index  -5.5 ° (C=1, H2O) storage temp.  Refrigerator solubility  H2O: 0.1 g/mL, clear, colorless pka 11.86±0.20(Predicted) form  neat color  White to Off-White optical activity [α]/D -5.8±0.8°, c = 1 in H2O Merck  14,9030 BRN  1724555 CAS DataBase Reference 87-81-0(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  24/25-36-26 WGK Germany  3 RTECS  WW1100000 F  3-10 HS Code  29400000 MSDS Information Provider Language SigmaAldrich English ACROS English ALFA English   D-tagatose Usage And Synthesis Description D-tagatose is a carbohydrate occurring in small amounts in several foods. The solubility in water is approximately 580 g/L at room temperature. As a ketohexose, tagatose reacts in foods in browning reactions like other ketohexoses, for example, fructose. Tagatose is, depending on the concentration, approximately 92 % as sweet as sucrose and noncariogenic. The caloric value of tagatose is generally set to 1.5 kcal/g. In the European Union, tagatose is approved as a novel food. In the United States, tagatose has GRAS status and it is also approved in many other countries. Chemical Properties Tagatose is a white, anhydrous crystalline solid. It is a carbohydrate, a ketohexose, an epimer of D-fructose inverted at C-4. It can exist in several tautomeric forms. Chemical Properties white to off-white crystalline powder Uses A monosaccharide (hexose) that can be used as a low-calorie sweetener, as an intermediate for synthesis of other optically active compounds, and as an additive in detergent, cosmetic, and pharmaceutical formulation. Uses D-(-)-Tagatose has been used as a carbohydrates for fermentation. It has also been used as one of the standards to confirm the identity of majority of the metabolites selected by least absolute shrinkage and selection operator (LASSO). Uses D-tagatose is a compound useful in organic synthesis. Production Methods Tagatose is obtained from D-galactose by isomerization under alkaline conditions in the presence of calcium. Biotechnological Production Tagatose is produced from galactose, which can be obtained by enzymatic hydrolysis of lactose, the main carbohydrate of milk. Galactose is separated from glucose by chromatography and either isomerized by treatment with calcium hydroxide, subsequent precipitation of calcium carbonate with carbon dioxide, filtration, demineralization with ion exchangers and crystallization [15], or converted enzymatically. Especially high conversion rates of 96.4 % were obtained with an enzyme extract of an engineered E. coli, and of 60 % at 95 C for A. flavithermus in the presence of borate. Conversion rates of 58 % were reported for an enzyme obtained from a mutant of G. thermodenitrificans [100], of 54 % at 60 C for a recombinant enzyme of Thermus sp. expressed in E. coli, and of more than 50 % at 75 C for E. coli containing an enzyme of A. cellulolytics. Immobilized enzymes or whole cells were used for practical applications. In some studies, high yields and productivities were achieved. Immobilized L-arabinose isomerase in calcium alginate produced 145 g/L of tagatose with 48 % conversion of galactose and a productivity of 54 g/Lh in a packed-bed reactor. An enzyme of T. mathranii immobilized in calcium alginate had its optimum at 75 C with a conversion rate of 43.9 % and a productivity up to 10 g/Lh with, however, lower conversion. After incubation of the resulting syrup with S. cerevisiae, purities above 95 % were achieved. The enzyme of T. neapolitana immobilized on chitopearl beds gave a tagatose concentration of 138 g/L at 70 C. Lactobacillus fermentum immobilized in calcium alginate had a temperature optimum of 65 C. A conversion rate of 60 % and a productivity of 11.1 g/Lh were obtained in a packed-bed reactor after addition of borate. Direct production of tagatose in yogurt was possible by expressing the enzyme of B. stearothermophilus in Lactobacillus bulgaricus and Streptococcus thermophilus. Pharmaceutical Applications Tagatose is used as a sweetening agent in beverages, foods, and pharmaceutical applications. A 10% solution of tagatose is about 92% as sweet as a 10% sucrose solution. It is a low-calorie sugar with approximately 38% of the calories of sucrose per gram. It occurs naturally in low levels in milk products. Like other sugars (fructose, glucose, sucrose), it is also used as a bulk sweetener, humectant, texturizer, and stabilizer, and may be used in dietetic foods with a low glycemic index. Biological Activity D-Tagatose, a ketohexose acts as a low-calorie functional sweetener. Tagatose can be used as a preservative in cosmetic, detergent and pharmaceutical formulations.Tagatose is also used in diet soft drinks, chewing gum, frozen yogurt and non-fat ice cream. Potential sugar substitute rarely found in nature. Produced using a biotransformation method with L-arabinose isomerase as the biocatalyst and D-galactose as the substrate. Side effects Some human trials of D-tagatose have found that doses of 30 grams or more cause gastrointestinal side effects like flatulence, diarrhea, nausea, and vomiting. However, only a minority of people appear to be affected, and mostly only with light to moderate symptom severity. The GI side effects of D-tagatose seem to be unpleasant but harmless. They’re may be due to osmotic (water-retaining) effects of high D-tagatose doses moving through your intestines. D-tagatose may interact with some prescription drugs, especially blood sugar lowering drugs, and could cause hypoglycemia (dangerously low blood sugar levels). And in people with diabetes or a history of kidney stones, temporary rises in uric acid blood levels caused by high dose D-tagatose may be an issue. Safety Tagatose is safe for use in food and beverages. It has been used in pharmaceutical products. storage Tagatose is stable under pH conditions typically encountered in foods (pH>3). It is a reducing sugar and undergoes the Maillard reaction. Tagatose is stable under typical storage conditions. It caramelizes at elevated temperature. Purification Methods Crystallise D(-)-tagatose from EtOH/H2O (6:1). It mutarotates from [] 22D +2o (2minutes) to –5.0o (30minutes) (c 4, H2O). The phenylosazone crystallises from aqueous EtOH with m 185-187o(dec), and [] 23D +47o (c 0.82, 2-methoxyethanol). [Totton & Lardy J Am Chem Soc 71 3076 1949, Gorin et al. Canad J Chem 33 1116 1955, Reichestein & Bossard Helv Chem Acta 17 753 1934, Wolfrom & Bennett J Org Chem 30 1284 1965, Beilstein 1 IV 4414.] In D2O at 27o 1H NMR showed the following ratios: -pyranose (79), -pyranose (16), -furanose (1) and -furanose (4) [Angyal Adv Carbohydr Chem 42 15 1984, Angyal & Pickles Aust J Chem 25 1711 1972]. Incompatibilities A Maillard-type condensation reaction is likely to occur between tagatose and compounds with a primary amine group to form brown or yellow-brown colored Amidori compounds. Reducing sugars will also interact with secondary amines to form an imine, but without any accompanying yellow-brown discoloration. Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (oral and rectal solutions).   D-tagatose Preparation Products And Raw materials Raw materials Lactulose-->BETA-D-LACTOSE-->D-Galactose Preparation Products NA